1. bookVolume 59 (2021): Issue 4 (December 2021)
Journal Details
License
Format
Journal
First Published
30 Mar 2015
Publication timeframe
4 times per year
Languages
English
access type Open Access

Hashimoto’s thyroiditis is associated with elevated serum uric acid to high density lipoprotein-cholesterol ratio

Published Online: 20 Nov 2021
Page range: 403 - 408
Received: 17 May 2021
Journal Details
License
Format
Journal
First Published
30 Mar 2015
Publication timeframe
4 times per year
Languages
English
Abstract

Background. Hashimoto’s thyroiditis (HT) is an auto-immune condition characterized with lymphocytic and fibroblastic infiltration of the thyroid gland. The rate of uric acid and HDL cholesterol – so called as uric acid to HDL ratio (UHR) has been shown to be elevated in inflammatory conditions diseases. We aimed to compare UHR and other laboratory parameters of the patients with HT to those values in healthy controls.

Methods. The patients diagnosed with HT by medical history, physical examination, elevated thyroid autoantibodies in serum and characteristic sonographic findings in outpatient internal medicine clinics of our institution were enrolled to the present retrospective study. Age and sex matched healthy volunteers were enrolled as controls. UHR of the HT patients and control subjects were compared.

Results. The mean UHR of the HT group was 11% ± 4 %, while UHR of the control group was 8% ± 2% (p<0.001). UHR was significantly and positively correlated with thyroid stimulating hormone (TSH) (r=0.26, p=0.01) and negatively correlated with free T4 (FT4) (r=−0.22, p=0.04) levels. The sensitivity and specificity of the UHR level were greater than 8.3%: were 74% and 52%, respectively (AUC: 0.74, p<0.001, 95% CI: 0.64–0.84).

Conclusion. We suggest that UHR is a reliable and useful marker for HT. Therefore, it may be helpful in establishing the diagnosis of HT in addition to other diagnostic tools.

Keywords

1. SIEGMANN EM, MÜLLER HHO, LUECKE C, PHILIPSEN A, KORNHUBER J, GRÖMER TW. Association of Depression and Anxiety Disorders With Autoimmune Thyroiditis: A Systematic Review and Meta-analysis. JAMA Psychiatry 2018;75:577–584. Search in Google Scholar

2. ANTONELLI A, FERRARI SM, CORRADO A, DI DOMENICANTONIO A, FALLAHI P. Autoimmune thyroid disorders. Autoimmun Rev 2015;14:174–180. Search in Google Scholar

3. TÜREMEN EE, ÇETINARSLAN B, ŞAHIN T, CANTÜRK Z, TARKUN İ. Endothelial dysfunction and low grade chronic inflammation in subclinical hypothyroidism due to autoimmune thyroiditis. Endocr J 2011;58:349–354. Search in Google Scholar

4. VOLPÉ R. The pathology of thyroiditis. Hum Pathol 1978;9:429–438. Search in Google Scholar

5. DUNTAS LH, BRENTA G. A Renewed Focus on the Association Between Thyroid Hormones and Lipid Metabolism. Front Endocrinol (Lausanne) 2018;9:511. Search in Google Scholar

6. CANARIS GJ, MANOWITZ NR, MAYOR G, RIDGWAY EC. The Colorado thyroid disease prevalence study. Arch Intern Med 2000;160:526–534. Search in Google Scholar

7. TAGAMI T, KIMURA H, OHTANI S, TANAKA T, TANAKA T, HATA S, SAITO M, MIYAZAKI Y, ARAKI R, TANAKA M, et al. Multi-center study on the prevalence of hypothyroidism in patients with hypercholesterolemia. Endocr J 2011;58:449–457. Search in Google Scholar

8. VUKOVIC R, ZELJKOVIC A, BUFAN B, SPASOJEVIC-KALIMANOVSKA V, MILENKOVIC T, VEKIC J. Hashimoto Thyroiditis and Dyslipidemia in Childhood: A Review. Front Endocrinol (Lausanne) 2019;10:868. Search in Google Scholar

9. KIMURA Y, YANAGIDA T, ONDA A, TSUKUI D, HOSOYAMADA M, KONO H. Soluble Uric Acid Promotes Atherosclerosis via AMPK (AMP-Activated Protein Kinase)-Mediated Inflammation. Arterioscler Thromb Vasc Biol 2020;40:570–582. Search in Google Scholar

10. KOCAK MZ, AKTAS G, ERKUS E, SINCER I, ATAK B, DUMAN T. Serum uric acid to HDL-cholesterol ratio is a strong predictor of metabolic syndrome in type 2 diabetes mellitus. Rev Assoc Med Bras (1992) 2019;65:9–15. Search in Google Scholar

11. AKTAS G, KOCAK MZ, BILGIN S, ATAK BM, DUMAN TT, KURTKULAGI O. Uric acid to HDL cholesterol ratio is a strong predictor of diabetic control in men with type 2 diabetes mellitus. Aging Male 2019:1–5. Search in Google Scholar

12. ZHANG Y-N, WANG Q-Q, CHEN Y-S, SHEN C, XU C-F. Association between serum uric acid to HDL-cholesterol ratio and nonalcoholic fatty liver disease in lean Chinese adults. International journal of endocrinology 2020;2020. Search in Google Scholar

13. HAMMERSTAD SS, JAHNSEN FL, TAURIAINEN S, HYÖTY H, PAULSEN T, NORHEIM I, DAHL-JØRGENSEN K. Inflammation and increased myxovirus resistance protein A expression in thyroid tissue in the early stages of Hashimoto’s thyroiditis. Thyroid 2013;23:334–341. Search in Google Scholar

14. ATAK BM, DUMAN TT, KOCAK MZ, SAVLI H. Serum uric acid level is associated with type 2 diabetes mellitus and diabetic regulation. Experimental Biomedical Research 2018;1:135–139. Search in Google Scholar

15. JOHNSON RJ, NAKAGAWA T, SANCHEZ-LOZADA LG, SHAFIU M, SUNDARAM S, LE M, ISHIMOTO T, SAUTIN YY, LANASPA MA. Sugar, uric acid, and the etiology of diabetes and obesity. Diabetes 2013;62:3307–3315. Search in Google Scholar

16. ISHIZAKA N, ISHIZAKA Y, TODA E, NAGAI R, YAMAKADO M. Association between serum uric acid, metabolic syndrome, and carotid atherosclerosis in Japanese individuals. Arterioscler Thromb Vasc Biol 2005;25:1038–1044. Search in Google Scholar

17. DEHGHAN A, KÖTTGEN A, YANG Q, HWANG SJ, KAO WL, RIVADENEIRA F, BOERWINKLE E, LEVY D, HOFMAN A, ASTOR BC, et al. Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study. Lancet 2008;372:1953–1961. Search in Google Scholar

18. AKTAS G, KOCAK MZ, DUMAN TT, ERKUS E, ATAK BM, SIT M, SAVLI H. Mean Platelet Volume (MPV) as an inflammatory marker in type 2 diabetes mellitus and obesity. Bali Med J 2018;7:650-653. Search in Google Scholar

19. EID BG, NEAMATALLAH T, HANAFY A, EL-BASSOSSY HM, BINMAHFOUZ L, ALDAWSARI HM, HASAN A, EL-AZIZ GA, VEMURI K, MAKRIYANNIS A. Interference with TGFβ1-Mediated Inflammation and Fibrosis Underlies Reno-Protective Effects of the CB1 Receptor Neutral Antagonists AM6545 and AM4113 in a Rat Model of Metabolic Syndrome. Molecules 2021;26. Search in Google Scholar

20. AKTAS G, ALCELIK A, TEKCE BK, SAVLI H, UYETURK U, KURT M, TEKELIOGLU V, YUCE Y. Mean platelet volume and red cell distribution width in hepatosteatosis. National journal of medical research 2013;3:264–266. Search in Google Scholar

21. AKTAS G, DUMAN TT, KURTKULAGI O, TEL BMA, BILGIN S, KAHVECI G, OKU A, KOSEKLI MA. Liver Steatosis is Associated Both with Platelet Distribution Width, Neutrophil/Lymphocyte and Monocyte/Lymphocyte Ratios. Primary Health Care: Open Access 2020;10:1–4. Search in Google Scholar

22. KOSEKLI MA, ERKUS E, KOCAK MZ. Mean Platelet Volume to Platelet ratio as a promising marker of hepatosteatosis. Experimental Biomedical Research 2018;1:55–59. Search in Google Scholar

23. AKTAS G, SIT M, DIKBAS O, TEKCE BK, SAVLI H, TEKCE H, ALCELIK A. Could red cell distribution width be a marker in Hashimoto’s thyroiditis? Exp Clin Endocrinol Diabetes 2014;122:572–574. Search in Google Scholar

24. AKTAS G, SIT M, DIKBAS O, ERKOL H, ALTINORDU R, ERKUS E, SAVLI H. Elevated neutrophil-to-lymphocyte ratio in the diagnosis of Hashimoto’s thyroiditis. Rev Assoc Med Bras (1992) 2017;63:1065-1068. Search in Google Scholar

25. DUNTAS LH. Thyroid disease and lipids. Thyroid 2002;12:287–293. Search in Google Scholar

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