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Journal
First Published
30 Mar 2015
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4 times per year
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English
access type Open Access

New markers of oxidative stress in lichen planus and the influence of hepatitis C virus infection – a pilot study

Published Online: 05 May 2021
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Received: 22 Nov 2020
Journal Details
License
Format
Journal
First Published
30 Mar 2015
Publication timeframe
4 times per year
Languages
English
Abstract

Introduction. Lichen planus (LP) is a mucocutaneous T-cell mediated disorder of unknown etiology. There is growing evidence that oxidative stress is an important player in the pathogenesis of LP. Therefore, we have investigated oxidative stress markers in LP and the influence of hepatitis C virus (HCV) infection, a frequently associated condition, on oxidative stress in LP patients.

Method. We have determined the serum levels of 4- hydroxynonenal (4-HNE) and symmetric dimethylarginine (SDMA), as markers of oxidative stress, and total antioxidant capacity (TAC), as a marker of the antioxidant defence, in 4 groups: group A - HCV positive patients with LP (n=12), group B - HCV positive patients without LP (n=12), group C - HCV negative patients with LP (n=31) and group D - control group (n=26).

Results. In LP patients, we have identified an increased level of lipid peroxidation (4-HNE - group A - 8.41±1.11 µg/mL, group B - 7.97±2.17 µg/mL, group C - 7.81±1.96 µg/mL and group D - 6.15±1.17 µg/mL) and alterations in arginine methylation (SDMA - group A - 1.10±0.24 µmol/L, group B - 1.03±0.16 µmol/L, group C - 0.84±0.19 µmol/L and group D - 0.50±0.06 µmol/L) associated with a diminished antioxidant defence (TAC - group A - 234,50±49,96, µmol/L group B - 255,83±41,41 µmol/L, group C - 269,83±43,33 µmol/L and group D - 316,46 ±29,33 µmol/L), processes augmented by the association with HCV infection.

Conclusion. There is an imbalance between oxidants and antioxidants in patients with LP, an imbalance that is augmented by the presence of HCV infection. SDMA could be regarded as a novel biomarker of oxidative stress among these patients. To the best of our knowledge this is the first study to investigate the influence of HCV infection on oxidative stress in LP patients.

Keywords

1. BETTERIDGE DJ. What Is Oxidative Stress? Metabolism. 2000;49:3–8.Search in Google Scholar

2. BURTON GJ., JAUNIAUX E. Oxidative stress. Best Pract Res Clin Obstet Gynaecol. 2011;25:287–99.Search in Google Scholar

3. YOSHIKAWA T., NAITO Y. What Is Oxidative Stress? Japan Med Assoc J. 2002;45:271–6.Search in Google Scholar

4. SHIRZAD A., POURAMIR M., SEYEDMAJIDI M., JENABIAN N., BIJANI A., MOTALLEBNEJAD M. Salivary Total Antioxidant Capacity and Lipid Peroxidation in Patients with Erosive Oral Lichen Planus. J Dent Res Dent Clin Dent Prospects. 2014;8:35-9.Search in Google Scholar

5. SCHLOSSER BJ. Lichen planus and lichenoid reactions of the oral mucosa. Dermatol Ther. 2010;23:251–67.Search in Google Scholar

6. TAMPA M., CARUNTU C., MITRAN MI., MITRAN CI., SARBU MI., RUSU LC., et al. Markers of Oral Lichen Planus Malignant Transformation. Dis Markers. 2018;1959506:2018.Search in Google Scholar

7. GEORGESCU SR., ENE CD., NICOLAE IL., MITRAN MI., MUSETESCU AL., MATEI C., et al. Reflectometric analysis for identification of various pathological conditions associated with lichen planus. Rev Chim. 2017;68:1103–8.Search in Google Scholar

8. CARROZZO M., SCALLY K. Oral manifestations of hepatitis C virus infection. World J Gastroenterol. 2014;20:7534–43.Search in Google Scholar

9. ROMERO MA., SEOANE J., VARELA-CENTELLES P., DIZ-DIOS P., OTERO XL. Clinical and pathological characteristics of oral lichen planus in hepatitis C-positive and -negative patients. Clin Otolaryngol Allied Sci. 2002;27:22–6.Search in Google Scholar

10. BĂLĂNESCU P., LĂDARU A., VOIOSU T., NICOLAU A., ENE M., BĂLĂNESCU E. Th17 and IL-17 immunity in chronic hepatitis C infection. Rom J Intern Med. 2012;50(1):13-8.Search in Google Scholar

11. GEORGESCU SR., TAMPA M., MITRAN MI., MITRAN CI., SARBU MI., NICOLAE I., et al. Potential pathogenic mechanisms involved in the association between lichen planus and hepatitis C virus infection. Exp Ther Med. 2019;17:1045–51.Search in Google Scholar

12. PAYERAS MR., CHERUBINI K., FIGUEIREDO MA., SALUM FG. Oral lichen planus: focus on etiopathogenesis. Arch Oral Biol. 2013;58:1057–69.Search in Google Scholar

13. ALY DG., SHAHIN RS. Oxidative stress in lichen planus. Acta Dermatovenerol Alp Panonica Adriat. 2010;19:3–11.Search in Google Scholar

14. MITRAN MI., NICOLAE I., ENE CD., MITRAN CI., MATEI C., ENE C., et al. Relationship between gamma-glutamyl transpeptidase activity and inflammatory response in lichen planus. Rev Chim. 2018;69:739–43.Search in Google Scholar

15. PARACHA UZ., FATIMA K., ALQAHTANI M., CHAUDHARY A., ABUZENADAH A., DAMANHOURI G., et al. Oxidative stress and hepatitis C virus. Virol J. 2013;10:251.Search in Google Scholar

16. JANKOVIC A., SASO L., KORAC A., KORAC B. Relation of Redox and Structural Alterations of Rat Skin in the Function of Chronological Aging. Oxid Med Cell Longev. 2019;2471312:2019.Search in Google Scholar

17. NICOLAE I., ENE CD., GEORGESCU SR., TAMPA M., MATEI C., CEAUSU E. Effects of UV Radiation and Oxidative DNA Adduct 8-hydroxy-2′-deoxiguanosine on the Skin Diseases. Rev Chim. 2014;65:1036–41.Search in Google Scholar

18. PERLUIGI M., COCCIA R., BUTTERFIELD DA. 4-Hydroxy-2-nonenal., a reactive product of lipid peroxidation., and neurodegenerative diseases: a toxic combination illuminated by redox proteomics studies. Antioxid Redox Signal. 2012;17:1590–609.Search in Google Scholar

19. ŁUCZAJ W., GĘGOTEK A., SKRZYDLEWSKA E. Antioxidants and HNE in redox homeostasis. Free Radic Biol Med. 2017;111:87–101.Search in Google Scholar

20. ERGUN S., TROŞALA ŞC., WARNAKULASURIYA S., ÖZEL S., ÖNAL AE., OFLUOĞLU D. Evaluation of oxidative stress and antioxidant profile in patients with oral lichen planus: oxidative stress and antioxidant profile in OLP. J Oral Pathol Med. 2011;40:286–93.Search in Google Scholar

21. SOHAL RS. Role of oxidative stress and protein oxidation in the aging process. Free Radic Biol Med. 2002;33:37–44.Search in Google Scholar

22. OLIVA-DAMASO E., OLIVA-DAMASO N., RODRIGUEZ-ESPARRAGON F., PAYAN J., BAAMONDE-LABORDA E., GONZALEZ-CABRERA F. Asymmetric (ADMA) and Symmetric (SDMA) Dimethylarginines in Chronic Kidney Disease: A Clinical Approach. Int J Mol Sci. 2019;20(15):3668–75.Search in Google Scholar

23. SEZER E., OZUGURLU F., OZYURT H., SAHIN S., ETIKAN I. Lipid peroxidation and antioxidant status in lichen planus. Clin Dermatol. 2007;32:430–4.Search in Google Scholar

24. KARAM BS., CHAVEZ-MORENO A., KOH W., AKAR JG., AKAR FG. Oxidative stress and inflammation as central mediators of atrial fibrillation in obesity and diabetes. Cardiovasc Diabetol. 2017;16:120.Search in Google Scholar

25. GORRINI C., HARRIS IS., MAK TW. Modulation of oxidative stress as an anticancer strategy. Nat Rev Drug Discov. 2013;12:931–47.Search in Google Scholar

26. BISWAS SK. Does the Interdependence between Oxidative Stress and Inflammation Explain the Antioxidant Paradox? Oxid Med Cell Longev. 2016;2016:1–9.Search in Google Scholar

27. YAMANE D., MCGIVERN DR., WAUTHIER E., YI M., MADDEN VJ., WELSCH C., et al. Regulation of the hepatitis C virus RNA replicase by endogenous lipid peroxidation. Nat Med. 2014;20:927–35.Search in Google Scholar

28. AMARA A., CONSTANS J., CHAUGIER C., SEBBAN A., DUBOURG L., PEUCHANT E., et al. Autoantibodies to malondialdehyde-modified epitope in connective tissue diseases and vasculitides. Clin Exp Immunol. 1995;101:233–8.Search in Google Scholar

29. BARRERA G., PIZZIMENTI S., DAGA M., DIANZANI C., ARCARO A., CETRANGOLO GP., et al. Lipid peroxidation-derived aldehydes., 4-hydroxynonenal and malondialdehyde in aging-related disorders. Antioxidants. 2018;7:E102.Search in Google Scholar

30. BREITZIG M., BHIMINENI C., LOCKEY R., KOLLIPUTI N. 4-Hydroxy-2-nonenal: A critical target in oxidative stress? Am J Physiol Cell Physiol. 2016;311:C537–43.Search in Google Scholar

31. 26. SCHAUR RJ., SIEMS W., BRESGEN N., ECKL PM. 4-Hydroxy-nonenal - A bioactive lipid peroxidation product. Biomolecules. 2015;5:2247–337.Search in Google Scholar

32. PARADIS V., MATHURIN P., KOLLINGER M., IMBERT-BISMUT F., CHARLOTTE F., PITON A., et al. In situ detection of lipid peroxidation in chronic hepatitis C: correlation with pathological features. J Clin Pathol. 1997;50:401–6.Search in Google Scholar

33. KONISHI M., IWASA M., ARAKI J., KOBAYASHI Y., KATSUKI A., SUMIDA Y., et al. Increased lipid peroxidation in patients with non-alcoholic fatty liver disease and chronic hepatitis C as measured by the plasma level of 8-isoprostane. J Gastroenterol Hepatol. 2006;21:1821–5.Search in Google Scholar

34. MORIYA K., NAKAGAWA K., SANTA T., SHINTANI Y., FUJIE H., MIYOSHI H., et al. Oxidative stress in the absence of inflammation in a mouse model for hepatitis C virus-associated hepatocarcinogenesis. Cancer Res. 2001;61:4365–70.Search in Google Scholar

35. TAIN Y., HSU C. Toxic Dimethylarginines: Asymmetric Dimethylarginine (ADMA) and Symmetric Dimethylarginine (SDMA). Toxins (Basel). 2017;9:92–6.Search in Google Scholar

36. DINU L., ENE CD., NICOLAE I., TAMPA M., MATEI C., GEORGESCU SR. The serum levels of 8-hidroxy-deoxyguanosine under the chemicals influence. Rev Chim. 2014;65:1319–26.Search in Google Scholar

37. PISOSCHI AM., POP A. The role of antioxidants in the chemistry of oxidative stress: A review. Eur J Med Chem. 2015;97:55–74.Search in Google Scholar

38. BARIKBIN B., YOUSEFI M., RAHIMI H., HEDAYATI M., RAZAVI SM., LOTFI S. Antioxidant status in patients with lichen planus. Clinical and Experimental Dermatology. Clin Dermatol. 2011;36:851–4.Search in Google Scholar

39. BACCI C., VANZO V., FRIGO AC., STELLINI E., SBRICOLI L., VALENTE M. Topical tocopherol for treatment of reticular oral lichen planus: A randomized., double-blind., crossover study. Oral Dis. 2017;23:62–8.Search in Google Scholar

40. HASHEMY SI., GHARAEI S., VASIGH S., KARGOZAR S., ALIREZAEI B., KEYHANI FJ, et al. Oxidative stress factors and C-reactive protein in patients with oral lichen planus before and 2 weeks after treatment. J Oral Pathol Med. 2016;45:35-40.Search in Google Scholar

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