<abstract xmlns="http://www.w3.org/1999/xhtml"><bold>Introduction.</bold> IgA nephropathy (IgAN) is a heterogeneous disease with highly variable clinical and histopathological features. We investigated the effects of Oxford classification and clinical features on renal survival in patients with IgAN.<bold>Methods.</bold> This retrospective observational study conducted from 2013 to 2017. Ninety-seven patients who were followed up more than six months were examined.<bold>Results.</bold> A total of 97 patients (68% male and median age 40 years) were enrolled in this study. 13% of patients developed end stage renal disease (ESRD) within the median of 37 months of follow-up. Need for renal replacement therapy at the time of diagnosis, serum creatinine level of higher than 1.97 mg/dl, serum albumin level less than 3.5 gr/dl, 24-hour urine protein level of higher than > 3.5 g/day, the percentage of glomerulosclerosis higher than 53%, T2 score and total MEST-C score higher than two were found to be significant predictors of development of ESRD. None of the clinical or histopathological features were found to be significant predictor of steroid treatment sensitivity except T1-2 scores.<bold>Conclusion.</bold> We think that IgA nephropathy is a heterogeneous disease that requires clinical and histopathological features to be evaluated together, but not individually, to determine renal survival.<bold>What is new.</bold> Iga nephropathy is a heterogeneous disease and modern pathologic classification systems is not enough to predict to prognosis. Histopathological features to be evaluated with clinical features, but not individually, to determine renal survival. Also glucocorticoid treatment response seems to be independent from clinical and histopathological features except T1-2 score.</abstract>

Introduction. IgA nephropathy (IgAN) is a heterogeneous disease with highly variable clinical and histopathological features. We investigated the effects of Oxford classification and clinical features on renal survival in patients with IgAN.Methods. This retrospective observational study conducted from 2013 to 2017. Ninety-seven patients who were followed up more than six months were examined.Results. A total of 97 patients (68% male and median age 40 years) were enrolled in this study. 13% of patients developed end stage renal disease (ESRD) within the median of 37 months of follow-up. Need for renal replacement therapy at the time of diagnosis, serum creatinine level of higher than 1.97 mg/dl, serum albumin level less than 3.5 gr/dl, 24-hour urine protein level of higher than > 3.5 g/day, the percentage of glomerulosclerosis higher than 53%, T2 score and total MEST-C score higher than two were found to be significant predictors of development of ESRD. None of the clinical or histopathological features were found to be significant predictor of steroid treatment sensitivity except T1-2 scores.Conclusion. We think that IgA nephropathy is a heterogeneous disease that requires clinical and histopathological features to be evaluated together, but not individually, to determine renal survival.What is new. Iga nephropathy is a heterogeneous disease and modern pathologic classification systems is not enough to predict to prognosis. Histopathological features to be evaluated with clinical features, but not individually, to determine renal survival. Also glucocorticoid treatment response seems to be independent from clinical and histopathological features except T1-2 score.

Combining clinical features and MEST-C score in IgA nephropathy may be a better determinant of kidney survival

Yildirim Beyazit University Yenimahalle Education and Research Hospital

Romanian Journal of Internal Medicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Introduction. IgA nephropathy (IgAN) is a heterogeneous disease with highly variable clinical and histopathological features. We investigated the effects of...

Combining clinical features and MEST-C score in IgA nephropathy may be a better determinant of kidney survival

Published Online: Dec 17, 2020

Page range: 209 - 218

Received: Apr 19, 2020

DOI: https://doi.org/10.2478/rjim-2020-0025

Keywords
IgA nephropathy, glomerulonephritis, end stage kidney disease, glucocorticoid, Oxford classification

© 2020 Hasan Haci Yeter et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Combining clinical features and MEST-C score in IgA nephropathy may be a better determinant of kidney survival

Published Online: Dec 17, 2020

Page range: 209 - 218

Received: Apr 19, 2020

DOI: https://doi.org/10.2478/rjim-2020-0025

KeywordsIgA nephropathy, glomerulonephritis, end stage kidney disease, glucocorticoid, Oxford classification

© 2020 Hasan Haci Yeter et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
IgA nephropathy, glomerulonephritis, end stage kidney disease, glucocorticoid, Oxford classification