<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Cardiac resynchronization therapy (CRT) has become part of the standard of care for symptomatic patients with heart failure, reduced ejection fraction (HRrEF), and wide QRS, despite optimal medical therapy. Device technology, operator experience, and post-implant optimization on follow-up have significantly improved CRT response during the last decade. In parallel, conduction system pacing (CSP) has emerged as a new and potentially better tool for maintaining physiological ventricular activation in patients with antibradycardia pacing, as well as an alternative for dyssynchrony correction in HFrEF patients. The current review focuses on cardiac dyssynchrony pathophysiology and correction methods, clinical evidence on CRT and CSP as therapies for cardiac dyssynchrony, and the role of each according to clinical evidence and current guidelines for HFrEF treatment.</p>
</abstract>

Cardiac resynchronization therapy (CRT) has become part of the standard of care for symptomatic patients with heart failure, reduced ejection fraction (HRrEF), and wide QRS, despite optimal medical therapy. Device technology, operator experience, and post-implant optimization on follow-up have significantly improved CRT response during the last decade. In parallel, conduction system pacing (CSP) has emerged as a new and potentially better tool for maintaining physiological ventricular activation in patients with antibradycardia pacing, as well as an alternative for dyssynchrony correction in HFrEF patients. The current review focuses on cardiac dyssynchrony pathophysiology and correction methods, clinical evidence on CRT and CSP as therapies for cardiac dyssynchrony, and the role of each according to clinical evidence and current guidelines for HFrEF treatment.

How to treat cardiac dyssynchrony in heart failure with reduced ejection fraction

Romanian Journal of Cardiology

This work is licensed under the Creative Commons Attribution 4.0 International License.

Cardiac resynchronization therapy (CRT) has become part of the standard of care for symptomatic patients with heart failure, reduced ejection fraction (HRrEF),...

How to treat cardiac dyssynchrony in heart failure with reduced ejection fraction

Article Category: Review

Published Online: Mar 29, 2024

Page range: 1 - 6

DOI: https://doi.org/10.2478/rjc-2023-0027

Keywords
cardiac resynchronization therapy, left bundle branch area pacing, heart failure, LBBB, reduced left ventricular ejection fraction

© 2023 Stefan Bogdan et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

How to treat cardiac dyssynchrony in heart failure with reduced ejection fraction

Article Category: Review

Published Online: Mar 29, 2024

Page range: 1 - 6

DOI: https://doi.org/10.2478/rjc-2023-0027

Keywordscardiac resynchronization therapy, left bundle branch area pacing, heart failure, LBBB, reduced left ventricular ejection fraction

© 2023 Stefan Bogdan et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Keywords
cardiac resynchronization therapy, left bundle branch area pacing, heart failure, LBBB, reduced left ventricular ejection fraction