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The Effect of Oral Acetaminophen on Open Arterial Duct Closure in Premature Infants Less Than 32 Weeks

Noor Mohammad Noori
Noor Mohammad Noori
, 
Alireza Teimouri
Alireza Teimouri
, 
Abdollah Dehvari
Abdollah Dehvari
, 
Somayeh Bagheie
Somayeh Bagheie
 and 
Hossein Ansari
Hossein Ansari
   | Jun 30, 2023
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Article Category: Original Article
Published Online: Jun 30, 2023
Page range: 54 - 59
DOI: https://doi.org/10.2478/rjc-2023-0007
Keywords
© 2023 Noor Mohammad Noori et al., published by Sciendo
This work is licensed under the Creative Commons Attribution 4.0 International License.

Figure 1

The distribution of PDA closure in groups of neonates with and without acetaminophen intervention
The distribution of PDA closure in groups of neonates with and without acetaminophen intervention

Comparing some variables in preterm infants based on treatment

Variables Treatment Mean SD Mean Rank MWU P-value
Weight (gr) No 1249.79 205.44 69.83 2403.00 0.844
Yes 1252.86 193.92 71.17
Gestational Age (week) No 30.03 1.55 69.27 2364.00 0.714
Yes 30.11 1.53 71.73
Apgar in the first minute No 7.40 0.75 71.06 2411.00 0.86
Yes 7.37 0.78 69.94
Apgar in the fifth minute No 8.6 0.67 70.54 2447.50 0.991
Yes 8.61 0.62 70.46
LA/Ao No 1.58 0.09 72.15 2334.50 0.627
Yes 1.57 0.09 68.85
PDA size before treatment No 2.80 0.04 66.53 2172.00 0.247
Yes 2.81 0.05 74.47
PDA size after treatment No 0.67 1.20 76.56 2025.50 0.004
Yes 0.16 0.67 64.44

Logistic regression analysis on affective variables on PDA status after treatment

Regular Odds ratio Adjusted Odds ratio
Variables (Reference group) β Wald Sig. OR β Wald Sig. OR
Sex (male) 0.090 0.036 0.849 1.094 -0.391 0.465 0.495 0.677
Weight 0.002 2.556 0.11 1.002 0.001 0.616 0.432 1.001
Gestational Age 0.376 6.078 0.014 1.457 0.371 2.925 0.087 1.449
Apgar at the first minute 0.503 2.463 0.117 1.654 0.966 3.134 0.077 2.626
Apgar at the fifth minute 0.239 0.417 0.518 1.27 -0.803 1.753 0.185 0.448
Parity 2 (parity 1) 0.049 0.007 0.931 1.05 -0.542 0.664 0.415 0.582
Parity 3 or more (parity 1) 0.548 0.884 0.347 1.73 0.459 0.453 0.501 1.582
LA/Ao -1.893 0.474 0.491 0.151 -3.558 1.279 0.258 0.028
Treatment (No) 1.666 8.098 0.004 5.292 1.855 8.462 0.004 6.394

comparison between preterm neonates with PDA treatment with oral acetaminophen

Variables PDA closure Mean SD Mean Rank MWU P-value
Weight Yes 1259.85 194.99 36.29 80.00 0.201
No 1137.5 149.3 22.50
Gestational Age Yes 30.18 1.53 36.52 65.00 0.093
No 29.00 1.15 18.75
Apgar at the first minute Yes 7.42 0.77 36.76 49.00 0.033
No 6.50 0.58 14.75
Apgar at the fifth minute Yes 8.65 0.62 36.68 54.00 0.047
No 8.00 0.01 16.00
LA/Ao Yes 1.57 0.09 34.95 96.00 0.383
No 1.61 0.07 44.50
PDA size before treatment Yes 2.80 0.05 34.17 44.5.00 0.023
No 2.86 0.02 57.38

Normality test for quantities variables

Variables Mean SD K.S P-value
Weight 1251.32 199.05 0.132 <0.001
Age 30.07 1.53 0.213 <0.001
Apgar in the first minute 7.39 0.76 0.25 <0.001
Apgar in the fifth minute 8.61 0.64 0.308 <0.001
LA/Ao 1.58 0.09 0.116 <0.001
PDA size before treatment 2.80 0.05 0.086 0.013
PDA size after treatment 0.42 1.00 0.512 <0.001
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