Open Access

Apolipoprotein E polymorphism in a Romanian population

Rodica Diaconu
Rodica Diaconu
, 
Andreea-Ramona Dumitrașcu
Andreea-Ramona Dumitrașcu
, 
Elisa Liehn
Elisa Liehn
, 
Andrei Pîrvu
Andrei Pîrvu
, 
Mihai Ioana
Mihai Ioana
, 
Dragoș Alexandru
Dragoș Alexandru
, 
Eugen Țieranu
Eugen Țieranu
, 
Tudor-Adrian Bălșeanu
Tudor-Adrian Bălșeanu
 and 
Ionuț Donoiu
Ionuț Donoiu
   | Mar 18, 2023
Romanian Journal of Cardiology's Cover Image
About this article
Previous Article
Next Article
Cite
Article Category: Original Article
Published Online: Mar 18, 2023
Page range: 19 - 24
DOI: https://doi.org/10.2478/rjc-2022-0031
Keywords
© 2023 Rodica Diaconu et al., published by Sciendo
This work is licensed under the Creative Commons Attribution 4.0 International License.

Characteristics of the population.

Variables
Age (years) 48.04 ± 8.35
Sex (% male) 131 (70.05%)
Alcohol, n (%) 109 (58.28%)
Smoking, n (%) 96 (51.33%)
BMI, kg/m2 26.59 ± 3.88

The frequencies of ApoE alleles in European countries

Population, no. of individuals Allele count (%) Genotype (%) Reference
ε2 ε3 ε4 ε2/ε2 ε2/ε3 ε2/ε4 ε3/ε3 ε3/ε4 ε4/ε4
Romania, 187 6.9 96.25 28.49 0.5 4.8 1.6 66.12 24.73 2.1
East European Countries
Mean 7.74 82.28 9.96 0.85 13.24 1.25 71.7 17 1.5
Serbia, 93 6.67 83.33 10.0 0 13.33 0 70 13.33 3.33 [23]
Hungary, 757 7.8 81.9 10.3 0.7 12.8 1.6 66.9 16.9 1.1 [24, 25]
Ukraine, 96 13.5 77.1 9.4 2.1 20.8 2.1 59.4 14.6 1 [26]
Slovakia, 351 6,9 85.5 7.6 0.6 11.7 1.1 72.9 13.1 0.6 [27]
Czechia, 175 6.3 83.4 10.3 1.7 8.0 1.1 72.0 14.9 2.3 [28]
Poland, 137 5.5 83.9 10.6 0 13.81 1.81 96.67 25.32 1.66 [29]
Russia, 350 7.52 80.86 11.57 0.9 12.3 1.1 64.3 20.9 0.6 [26]
North European Countries
Mean 11.29 87.49 23.38 0.71 11.36 2.62 58.92 24.11 2.54
Norway, 395 8.7 78.1 13.2 0.8 12.7 2.3 61 20.5 1.7 [30]
Sweden, 750 14.8 89.7 32.6 0.65 11.1 3.05 55.9 22.7 1.9 [31, 32]
Estonia, 297 8.3 75.4 16.3 0.67 12.46 2.69 56.90 24.58 2.69 [33]
Lithuania, 1,035 10 78 11 0.4 16.6 3.3 61.3 17.3 1.1 [34]
Denmark, 466 8.5 74.1 17.4 1.7 11.6 1.9 55.8 25.1 3.9 [35]
Finland, 203 11.9 95.2 42.9 0.5 9.9 1.5 46.8 35.5 5.9 [24]
Iceland, 185 13.5 93.6 29.7 0 10.3 3.2 60.0 23.2 3.2 [24]
Ireland, 100 12 95 24 1 9 2 66 20 2 [36]
South European Countries
Mean 11.4 88.63 11.29 0.9 13.68 1 69.2 14.18 0.98
Bosnia, 170 12.6 78 9.4 1.8 19.4 2.4 60.5 14.7 1.2 [37]
Croatia, 456 5.7 85.5 8.8 0.2 10.5 0.5 71.9 16.7 0.2 [38]
Greece, 140 17.4 97.15 13.57 0.71 15.72 0.71 70.0 11.43 1.43 [39]
Portugal, 607 12.5 97.5 17.3 0.3 11.3 0.9 71.1 15.1 1.3 [40]
Spain, 399 7.5 85 7.4 1.5 11.5 0.5 72.5 13 0.8 [41]
West European Countries
Mean 9.67 78.17 17.8 0.9 12.12 2.1 58.87 23.45 2.35
Austria, 749 8.3 74.3 17.4 0.7 12.6 2.9 55.0 25.8 3.0 [24, 42]
Germany, 2,031 7.7 77.8 14.5 0.6 12.0 2.2 60.5 22.6 2.1 [43]
France, 498 14.5 85.5 22.5 1.6 11.9 1 64 20.1 1.4 [44]
Netherlands, 2,000 8.2 75.1 16.8 0.7 12.0 2.3 56.0 25.3 2.9 [45]

ApoE alleles frequency in Romanian population

Allele Allelic count (%)
ε3 180 (96.25%)
ε4 53 (28.49%)
ε2 13 (6.9%)
Genotype n (%)
ε3/ε3 123 (66.12%)
ε3/ε4 46 (24.73%)
ε2/ε3 9 (4.8%)
ε2/ε2 1 (0.5%)
ε2/ε4 3 (1.6%)
ε4/ε4 4 (2.1%)
eISSN:
2734-6382
Language:
English
Publication timeframe:
4 times per year
Journal Subjects:
Medicine, Clinical Medicine, Internal Medicine, Cardiology, Pediatrics and Juvenile Medicine, Paediatric Cardiology, Surgery, Cardiac Surgery
Journal RSS Feed