<abstract xmlns="http://www.w3.org/1999/xhtml"><p>There has been substantial interest in the use of ketamine for perioperative analgesia. Recently published articles on ‘low dose’ ketamine mark the resurgence in interest in the use of the drug for acute pain. Continued interest in ketamine as an anti-depressant also has opened the door to applications beyond the operating room. In this article, we will review: the history of ketamine’s clinical use; basic ketamine pharmacology; evidence for the use of perioperative ketamine for analgesia; comments on patient selection for ketamine research; a discussion of the safety and side effect profile of ketamine infusions beyond the operating room; and, lastly, ketamine as a treatment option for psychiatric diseases.</p></abstract>

There has been substantial interest in the use of ketamine for perioperative analgesia. Recently published articles on ‘low dose’ ketamine mark the resurgence in interest in the use of the drug for acute pain. Continued interest in ketamine as an anti-depressant also has opened the door to applications beyond the operating room. In this article, we will review: the history of ketamine’s clinical use; basic ketamine pharmacology; evidence for the use of perioperative ketamine for analgesia; comments on patient selection for ketamine research; a discussion of the safety and side effect profile of ketamine infusions beyond the operating room; and, lastly, ketamine as a treatment option for psychiatric diseases.

Perioperative ketamine for acute analgesia and beyond

Department of Anesthesiology and Perioperative Medicine

Romanian Journal of Anaesthesia and Intensive Care

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Perioperative ketamine for acute analgesia and beyond"}

There has been substantial interest in the use of ketamine for perioperative analgesia. Recently published articles on ‘low dose’ ketamine mark the resurgence...

Perioperative ketamine for acute analgesia and beyond

Published Online: Jun 18, 2019

Page range: 67 - 73

Received: Jun 15, 2018

Accepted: Mar 30, 2019

DOI: https://doi.org/10.2478/rjaic-2019-0010

Keywords
ketamine, perioperative analgesia, subanesthetic ketamine, acute pain, acute postoperative pain

© 2019 Steven B. Porter, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Perioperative ketamine for acute analgesia and beyond

Published Online: Jun 18, 2019

Page range: 67 - 73

Received: Jun 15, 2018

Accepted: Mar 30, 2019

DOI: https://doi.org/10.2478/rjaic-2019-0010

Keywordsketamine, perioperative analgesia, subanesthetic ketamine, acute pain, acute postoperative pain

© 2019 Steven B. Porter, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
ketamine, perioperative analgesia, subanesthetic ketamine, acute pain, acute postoperative pain