<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec><h3>Background</h3><p>Spine stereotactic body radiation therapy (SBRT) for the treatment of metastatic disease is increasingly utilized owing to improved pain and local control over conventional regimens. Vertebral body collapse (VBC) is an important toxicity following spine SBRT. We investigated our institutional experience with spine SBRT as it relates to VBC and spinal instability neoplastic score (SINS).</p></sec>
<sec><h3>Patients and methods</h3><p>Records of 83 patients with 100 spinal lesions treated with SBRT between 2007 and 2022 were reviewed. Clinical information was abstracted from the medical record. The primary endpoint was post-treatment VBC. Logistic univariate analysis was performed to identify clinical factors associated with VBC.</p></sec>
<sec><h3>Results</h3><p>Median dose and number of fractions used was 24 Gy and 3 fractions, respectively. There were 10 spine segments that developed VBC (10%) after spine SBRT. Median time to VBC was 2.4 months. Of the 11 spine segments that underwent kyphoplasty prior to SBRT, none developed subsequent VBC. No factors were associated with VBC on univariate analysis.</p></sec>
<sec><h3>Conclusions</h3><p>The rate of vertebral body collapse following spine SBRT is low. Prophylactic kyphoplasty may provide protection against VBC and should be considered for patients at high risk for fracture.</p></sec>
</abstract>

BackgroundSpine stereotactic body radiation therapy (SBRT) for the treatment of metastatic disease is increasingly utilized owing to improved pain and local control over conventional regimens. Vertebral body collapse (VBC) is an important toxicity following spine SBRT. We investigated our institutional experience with spine SBRT as it relates to VBC and spinal instability neoplastic score (SINS).
Patients and methodsRecords of 83 patients with 100 spinal lesions treated with SBRT between 2007 and 2022 were reviewed. Clinical information was abstracted from the medical record. The primary endpoint was post-treatment VBC. Logistic univariate analysis was performed to identify clinical factors associated with VBC.
ResultsMedian dose and number of fractions used was 24 Gy and 3 fractions, respectively. There were 10 spine segments that developed VBC (10%) after spine SBRT. Median time to VBC was 2.4 months. Of the 11 spine segments that underwent kyphoplasty prior to SBRT, none developed subsequent VBC. No factors were associated with VBC on univariate analysis.
ConclusionsThe rate of vertebral body collapse following spine SBRT is low. Prophylactic kyphoplasty may provide protection against VBC and should be considered for patients at high risk for fracture.

Vertebral body collapse after spine stereotactic body radiation therapy: a single-center institutional experience

Jacobs School of Medicine and Biomedical Sciences

Department of Radiation Medicine, Roswell Park Comprehensive Cancer Center

Radiology and Oncology

This work is licensed under the Creative Commons Attribution 4.0 International License.

BackgroundSpine stereotactic body radiation therapy (SBRT) for the treatment of metastatic disease is increasingly utilized owing to improved pain and local...

Vertebral body collapse after spine stereotactic body radiation therapy: a single-center institutional experience

Article Category: Research Article

Published Online: Jun 12, 2024

Page range: -

Received: Dec 26, 2023

Accepted: Apr 26, 2024

DOI: https://doi.org/10.2478/raon-2024-0033

Keywords
spine metastasis, stereotactic body radiation therapy, vertebral compression fracture, kyphoplasty, spinal instability

© 2024 Arsh Issany et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Vertebral body collapse after spine stereotactic body radiation therapy: a single-center institutional experience

Article Category: Research Article

Published Online: Jun 12, 2024

Page range: -

Received: Dec 26, 2023

Accepted: Apr 26, 2024

DOI: https://doi.org/10.2478/raon-2024-0033

Keywordsspine metastasis, stereotactic body radiation therapy, vertebral compression fracture, kyphoplasty, spinal instability

© 2024 Arsh Issany et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Keywords
spine metastasis, stereotactic body radiation therapy, vertebral compression fracture, kyphoplasty, spinal instability