<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec><h3>Background</h3><p>The high mortality rate of pancreatic ductal adenocarcinoma (PDAC) is primarily attributed to metastasis. Laminin subunit alpha 3 (LAMA3) is known to modulate tumor progression. However, the influence of LAMA3 on liver metastasis in PDAC remains unclear. This study aimed to elucidate whether LAMA3 expression is increased in PDAC with liver metastasis.</p></sec>
<sec><h3>Patients and methods</h3><p>We extracted information related to LAMA3 expression levels and associated clinicopathological parameters from The Cancer Genome Atlas (TCGA) and four Gene Expression Omnibus (GEO) datasets. Clinicopathological analysis was performed; the Kaplan-Meier Plotter was used to evaluate LAMA3’s prognostic effect in PDAC. We retrospectively collected clinicopathological data and tissue specimens from 117 surgically treated patients with PDAC at the Affiliated Hospital of Qingdao University. We assessed LAMA3 expression and investigated its correlation with the clinicopathological traits, clinical outcomes, and hepatic metastasis.</p></sec>
<sec><h3>Results</h3><p>Amplified expression of LAMA3 was observed in PDAC tissue compared with normal tissue in the TCGA and GEO databases. High LAMA3 expression was associated with poor overall survival (OS) and relapse-free survival (RFS) in patients with PDAC. LAMA3 expression was significantly enhanced in PDAC tissues than in adjacent tissues. Tumor tissues from patients with PDAC exhibiting liver metastasis showed higher LAMA3 expression than those without liver metastasis. High LAMA3 expression correlated with large tumor size and TNM stage. LAMA3 expression and liver metastasis were independent predictive factors for OS; the former was independently associated with liver metastasis.</p></sec>
<sec><h3>Conclusions</h3><p>LAMA3 expression is elevated in patients with PDAC with liver metastasis and is a predictor of prognosis.</p></sec>
</abstract>

BackgroundThe high mortality rate of pancreatic ductal adenocarcinoma (PDAC) is primarily attributed to metastasis. Laminin subunit alpha 3 (LAMA3) is known to modulate tumor progression. However, the influence of LAMA3 on liver metastasis in PDAC remains unclear. This study aimed to elucidate whether LAMA3 expression is increased in PDAC with liver metastasis.
Patients and methodsWe extracted information related to LAMA3 expression levels and associated clinicopathological parameters from The Cancer Genome Atlas (TCGA) and four Gene Expression Omnibus (GEO) datasets. Clinicopathological analysis was performed; the Kaplan-Meier Plotter was used to evaluate LAMA3’s prognostic effect in PDAC. We retrospectively collected clinicopathological data and tissue specimens from 117 surgically treated patients with PDAC at the Affiliated Hospital of Qingdao University. We assessed LAMA3 expression and investigated its correlation with the clinicopathological traits, clinical outcomes, and hepatic metastasis.
ResultsAmplified expression of LAMA3 was observed in PDAC tissue compared with normal tissue in the TCGA and GEO databases. High LAMA3 expression was associated with poor overall survival (OS) and relapse-free survival (RFS) in patients with PDAC. LAMA3 expression was significantly enhanced in PDAC tissues than in adjacent tissues. Tumor tissues from patients with PDAC exhibiting liver metastasis showed higher LAMA3 expression than those without liver metastasis. High LAMA3 expression correlated with large tumor size and TNM stage. LAMA3 expression and liver metastasis were independent predictive factors for OS; the former was independently associated with liver metastasis.
ConclusionsLAMA3 expression is elevated in patients with PDAC with liver metastasis and is a predictor of prognosis.

Correlation of laminin subunit alpha 3 expression in pancreatic ductal adenocarcinoma with tumor liver metastasis and survival

the Affiliated Hospital of Qingdao University

Radiology and Oncology

This work is licensed under the Creative Commons Attribution 4.0 International License.

BackgroundThe high mortality rate of pancreatic ductal adenocarcinoma (PDAC) is primarily attributed to metastasis. Laminin subunit alpha 3 (LAMA3) is known to...

Correlation of laminin subunit alpha 3 expression in pancreatic ductal adenocarcinoma with tumor liver metastasis and survival

Article Category: Research Article

Published Online: Mar 07, 2024

Page range: 234 - 242

Received: Oct 30, 2023

Accepted: Jan 14, 2024

DOI: https://doi.org/10.2478/raon-2024-0020

Keywords
pancreatic ductal adenocarcinoma, laminin subunit alpha 3, liver metastasis, prognosis

© 2024 Yueyi Xing et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Supplementary Material Details

Correlation of laminin subunit alpha 3 expression in pancreatic ductal adenocarcinoma with tumor liver metastasis and survival

Article Category: Research Article

Published Online: Mar 07, 2024

Page range: 234 - 242

Received: Oct 30, 2023

Accepted: Jan 14, 2024

DOI: https://doi.org/10.2478/raon-2024-0020

Keywordspancreatic ductal adenocarcinoma, laminin subunit alpha 3, liver metastasis, prognosis

© 2024 Yueyi Xing et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Supplementary Material Details

Keywords
pancreatic ductal adenocarcinoma, laminin subunit alpha 3, liver metastasis, prognosis