<abstract xmlns="http://www.w3.org/1999/xhtml"><sec id="j_raon-2021-0007_s_006_w2aab3b7c39b1b6b1aab1c16b1Aa"><h3>Background</h3><p>The aim of the study was to assess whether the configuration of primary soft-tissue sarcoma (STS) on MRI correlates with the grade of malignancy.</p></sec><sec id="j_raon-2021-0007_s_007_w2aab3b7c39b1b6b1aab1c16b2Aa"><h3>Patients and methods</h3><p>71 patients with histologically proven STS were included. Primary STS were examined for configuration, borders, and volume on MRI. The tumors were divided into high-grade (G3), intermediate-grade (G2) and low-grade (G1) STS according to the grading system of the French Federation of Cancer Centers Sarcoma Group (FNCLCC).</p></sec><sec id="j_raon-2021-0007_s_008_w2aab3b7c39b1b6b1aab1c16b3Aa"><h3>Results</h3><p>30 high-grade, 22 intermediate-grade and 19 low-grade primary STS lesions were identified. High- and intermediate-grade (G3/2) STS significantly most often appeared as polycyclic/multilobulated tumors (p &lt; 0.001 and p = 0.002, respectively). Low-grade (G1) STS mainly showed an ovoid/nodular or streaky configuration (p = 0.008), and well-defined borders. The appearance of high-, intermediate- and low-grade STS with an ovoid/nodular configuration were mainly the same on MRI. All streaky G3/2 sarcoma and 17 of 20 patients with polycyclic/multilobulated G3 sarcoma showed infiltrative borders. High-grade streaky and polycyclic/multilobulated STS are larger in volume, compared to intermediate- and low-grade STS.</p></sec><sec id="j_raon-2021-0007_s_009_w2aab3b7c39b1b6b1aab1c16b4Aa"><h3>Conclusions</h3><p>Configuration of STS on MRI can indicate the grade of malignancy. Higher-grade (G2/3) STS most often show a polycyclic/multilobulated configuration, while low-grade STS are mainly ovoid/nodular or streaky. Infiltrative behavior might suggest higher-grade STS in streaky and polycyclic/multilobulated STS.</p></sec></abstract>

BackgroundThe aim of the study was to assess whether the configuration of primary soft-tissue sarcoma (STS) on MRI correlates with the grade of malignancy.Patients and methods71 patients with histologically proven STS were included. Primary STS were examined for configuration, borders, and volume on MRI. The tumors were divided into high-grade (G3), intermediate-grade (G2) and low-grade (G1) STS according to the grading system of the French Federation of Cancer Centers Sarcoma Group (FNCLCC).Results30 high-grade, 22 intermediate-grade and 19 low-grade primary STS lesions were identified. High- and intermediate-grade (G3/2) STS significantly most often appeared as polycyclic/multilobulated tumors (p < 0.001 and p = 0.002, respectively). Low-grade (G1) STS mainly showed an ovoid/nodular or streaky configuration (p = 0.008), and well-defined borders. The appearance of high-, intermediate- and low-grade STS with an ovoid/nodular configuration were mainly the same on MRI. All streaky G3/2 sarcoma and 17 of 20 patients with polycyclic/multilobulated G3 sarcoma showed infiltrative borders. High-grade streaky and polycyclic/multilobulated STS are larger in volume, compared to intermediate- and low-grade STS.ConclusionsConfiguration of STS on MRI can indicate the grade of malignancy. Higher-grade (G2/3) STS most often show a polycyclic/multilobulated configuration, while low-grade STS are mainly ovoid/nodular or streaky. Infiltrative behavior might suggest higher-grade STS in streaky and polycyclic/multilobulated STS.

Configuration of soft-tissue sarcoma on MRI correlates with grade of malignancy

Radiology and Oncology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Configuration of soft-tissue sarcoma on MRI correlates with grade of malignancy"}

BackgroundThe aim of the study was to assess whether the configuration of primary soft-tissue sarcoma (STS) on MRI correlates with the grade of...

Configuration of soft-tissue sarcoma on MRI correlates with grade of malignancy

Article Category: Research Article

Published Online: Jan 29, 2021

Page range: 158 - 163

Received: Nov 11, 2020

Accepted: Dec 14, 2020

DOI: https://doi.org/10.2478/raon-2021-0007

© 2021 Sam Sedaghat, Mona Salehi Ravesh, Maya Sedaghat, Marcus Both, Olav Jansen, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.