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Radiological evaluation of ex novo high grade glioma: velocity of diametric expansion and acceleration time study

Roberto Altieri
Roberto Altieri
, 
Francesco Certo
Francesco Certo
, 
Giuseppe La Rocca
Giuseppe La Rocca
, 
Antonio Melcarne
Antonio Melcarne
, 
Diego Garbossa
Diego Garbossa
, 
Alberto Bianchi
Alberto Bianchi
, 
Salvatore Crimi
Salvatore Crimi
, 
Alessandro Pluchino
Alessandro Pluchino
, 
Simone Peschillo
Simone Peschillo
 and 
Giuseppe M.V. Barbagallo
Giuseppe M.V. Barbagallo
   | Dec 03, 2020
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Article Category: Research Article
Published Online: Dec 03, 2020
Page range: 26 - 34
Received: Jul 15, 2020
Accepted: Oct 16, 2020
DOI: https://doi.org/10.2478/raon-2020-0071
© 2021 Roberto Altieri, Francesco Certo, Giuseppe La Rocca, Antonio Melcarne, Diego Garbossa, Alberto Bianchi, Salvatore Crimi, Alessandro Pluchino, Simone Peschillo, Giuseppe M.V. Barbagallo, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Figure 1

MRI scans in Patient 2 at 0 (A), 18 (B) and 54 (C) days. (T1 with gadolinium sequences).
MRI scans in Patient 2 at 0 (A), 18 (B) and 54 (C) days. (T1 with gadolinium sequences).

Figure 2

MRI scans in Patient 3 at 0 (A), 465 (B), 742 (C), 790 (D), 811 (E), 825 (F) and 854 (G) days (fluid attenuated inversion recovery [FLAIR] and T1 with gadolinium sequences).
MRI scans in Patient 3 at 0 (A), 465 (B), 742 (C), 790 (D), 811 (E), 825 (F) and 854 (G) days (fluid attenuated inversion recovery [FLAIR] and T1 with gadolinium sequences).

Figure 3

MRI scans in Patient 4 at 0 (A), 160 (B), 196 (C) and 223 (D) days (fluid attenuated inversion recovery [FLAIR] and T1 with gadolinium sequences).
MRI scans in Patient 4 at 0 (A), 160 (B), 196 (C) and 223 (D) days (fluid attenuated inversion recovery [FLAIR] and T1 with gadolinium sequences).

Figure 4

Velocity of diameter expansion (VDE) variation of mean tumor diameter (MTD) for fluid attenuated inversion recovery [FLAIR] and enhancing nodule (EN) volumes for each patient. Plus the case reported by Mandonnet et al. as specified in Discussion paragraph. Graphic shows variation of acceleration (Acc) based on VDE (mm/days2) for FLAIR tumor volume and EN volume along time. Except obvious similar variation for two types of volume considered, peaks are easily notable. VDE of patient #1 is covered by patient #4.
Velocity of diameter expansion (VDE) variation of mean tumor diameter (MTD) for fluid attenuated inversion recovery [FLAIR] and enhancing nodule (EN) volumes for each patient. Plus the case reported by Mandonnet et al. as specified in Discussion paragraph. Graphic shows variation of acceleration (Acc) based on VDE (mm/days2) for FLAIR tumor volume and EN volume along time. Except obvious similar variation for two types of volume considered, peaks are easily notable. VDE of patient #1 is covered by patient #4.

Raw data about velocity of diameter expansion (VDE) of fluid attenuated inversion recovery (FLAIR) and enhancing nodule (EN) volume. Mean percentage maximal VDE/mean VDE ratio could help in early high grade gliomas (HGG) diagnosis

Interval of consecutive MRIVDE Pt #1 FLAIRVDE Pt #2 FLAIRVDE Pt #2 ENVDE Pt #3 FLAIRVDE Pt #3 ENVDE Pt #4 FLAIRVDE Pt #4 ENMean Values
135.50169.23311.8116.680.0011.9316.81
217.03258.82104.546.660.000.0010.81
332.24-52.97-94.9143.3964.140.000.00
464.5947.84
5155.18165.74
60.0048.53
Mean Values28.26125.03107.1547.7554.373.989.21
FLAIR VDE Peak/ VDE mean value ratio (percentage)125.63135.36324.99300.00221.49
EN VDE Peak/ VDE mean value ratio (percentage)291.02304.81182.57259.47
Mean Values240.48

Data on fluid attenuated inversion recovery (FLAIR) tumor and enhancing nodule (EN) volume velocity of diameter expansion (VDE). Reported as mm/year

Data about patient #1, #2, #3, #4

Raw data of mean acceleration (Acc) based on velocity of diameter expansion (VDE) of fluid attenuated inversion recovery (FLAIR) and enhancing nodule (EN) volume. Mean percentage maximal Acc/mean Acc ratio of each patient could help in early high grade gliomas (HGG) diagnosis

Interval of consecutive MRIAcc Pt #1 FLAIRAcc Pt #2 FLAIRAcc Pt #2 ENAcc Pt #3 FLAIRAcc Pt #3 ENAcc Pt #4 FLAIRAcc Pt #4 ENMean Values
10.00030.06620.12200.0001000.00020.0003
20.00050.03940.01590.0000700.00000.0008
30.0015-0.0040-0.00720.002480.00370.00000.0000
40.008430.0062
50.030370.0324
60.000000.0046
Mean Values0.00080.03390.04360.00690.00780.00010.0004
FLAIR Acc Peak/ Acc mean value ratio (percentage)195.6695195.5808439.7477300282.7495
EN Acc Peak/ Acc mean value ratio (percentage)280.0617414.751677.74935257.5209
Mean Values270.1352
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