<abstract xmlns="http://www.w3.org/1999/xhtml"><sec id="j_raon-2020-0001_s_005_w2aab3b8c43b1b7b1aab1c16b1Aa"><h3>Background</h3><p>The accuracy of any radiation therapy delivery is limited by target organ translocation and distortion. Bladder filling is one of the recognised factors affecting prostate translocation and distortion. The purpose of our study was to evaluate the effect of bladder volume on prostate translocation and distortion by using detailed three-dimensional prostate delineation on MRI.</p></sec><sec id="j_raon-2020-0001_s_006_w2aab3b8c43b1b7b1aab1c16b2Aa"><h3>Patients and methods</h3><p>Fifteen healthy male volunteers were recruited in this prospective, institutional review board-approved study. Each volunteer underwent 4 different drinking preparations prior to imaging, with MR images acquired pre- and post-void. MR images were co-registered by using bony landmarks and three-dimensional contouring was performed in order to assess the degree of prostate translocation and distortion. According to changes in bladder or rectum distention, subdivisions were made into bladder and rectal groups. Studies with concomitant change in both bladder and rectal volume were excluded.</p></sec><sec id="j_raon-2020-0001_s_007_w2aab3b8c43b1b7b1aab1c16b3Aa"><h3>Results</h3><p>Forty studies were included in the bladder volume study group and 8 in the rectal volume study group. The differences in rectal volumes yielded higher levels of translocation (<italic>p</italic> &lt; 0.01) and distortion (<italic>p</italic> = 0.02) than differences in bladder volume. Moderate correlation of prostate translocation with bladder filling was shown (<italic>r</italic> = 0.64, <italic>p</italic> &lt; 0.01). There was no important prostate translocation when bladder volume change was &lt; 2-fold (<italic>p</italic> &lt; 0.01). Moderate correlation of prostate distortion with bladder filling was shown (<italic>r</italic> = 0.61, <italic>p</italic> &lt; 0.01).</p></sec><sec id="j_raon-2020-0001_s_008_w2aab3b8c43b1b7b1aab1c16b4Aa"><h3>Conclusions</h3><p>Bladder volume has a minimal effect on prostate translocation and effect on prostate distortion is negligible. Prostate translocation may be minimalised if there is &lt; 2-fold increase in the bladder volume.</p></sec></abstract>

BackgroundThe accuracy of any radiation therapy delivery is limited by target organ translocation and distortion. Bladder filling is one of the recognised factors affecting prostate translocation and distortion. The purpose of our study was to evaluate the effect of bladder volume on prostate translocation and distortion by using detailed three-dimensional prostate delineation on MRI.Patients and methodsFifteen healthy male volunteers were recruited in this prospective, institutional review board-approved study. Each volunteer underwent 4 different drinking preparations prior to imaging, with MR images acquired pre- and post-void. MR images were co-registered by using bony landmarks and three-dimensional contouring was performed in order to assess the degree of prostate translocation and distortion. According to changes in bladder or rectum distention, subdivisions were made into bladder and rectal groups. Studies with concomitant change in both bladder and rectal volume were excluded.ResultsForty studies were included in the bladder volume study group and 8 in the rectal volume study group. The differences in rectal volumes yielded higher levels of translocation (p < 0.01) and distortion (p = 0.02) than differences in bladder volume. Moderate correlation of prostate translocation with bladder filling was shown (r = 0.64, p < 0.01). There was no important prostate translocation when bladder volume change was < 2-fold (p < 0.01). Moderate correlation of prostate distortion with bladder filling was shown (r = 0.61, p < 0.01).ConclusionsBladder volume has a minimal effect on prostate translocation and effect on prostate distortion is negligible. Prostate translocation may be minimalised if there is < 2-fold increase in the bladder volume.

Three-dimensional MRI evaluation of the effect of bladder volume on prostate translocation and distortion

Radiology and Oncology

This work is licensed under the Creative Commons Attribution 3.0 Public License.

BackgroundThe accuracy of any radiation therapy delivery is limited by target organ translocation and distortion. Bladder filling is one of the recognised...

Three-dimensional MRI evaluation of the effect of bladder volume on prostate translocation and distortion

Article Category: Research Article

Published Online: Jan 14, 2020

Page range: 48 - 56

Received: Nov 08, 2019

Accepted: Dec 19, 2019

DOI: https://doi.org/10.2478/raon-2020-0001

© 2020 Ziga Snoj, Andrew B. Gill, Leonardo Rundo, Nikita Sushentsev, Tristan Barrett, published by Sciendo

This work is licensed under the Creative Commons Attribution 3.0 Public License.