1. bookVolume 49 (2015): Issue 1 (March 2015)
Journal Details
First Published
30 Apr 2007
Publication timeframe
4 times per year
© 2020 Sciendo

Mild hyperthermia influence on Herceptin® properties

Published Online: 03 Mar 2015
Page range: 41 - 49
Received: 17 Aug 2014
Accepted: 24 Oct 2014
Journal Details
First Published
30 Apr 2007
Publication timeframe
4 times per year
© 2020 Sciendo

Background. Mild hyperthermia (mHT) increases the tumor perfusion and vascular permeability, and reduces the interstitial fluid pressure, resulting in better intra-tumoral bioavailability of low molecular weight drugs. This approach is potentially also attractive for delivery of therapeutic macromolecules, such as antibodies. Here, we investigated the effects of mHT on the stability, immunological and pharmacological properties of Herceptin®, a clinically approved antibody, targeting the human epidermal growth factor receptor 2 (HER-2) overexpressed in breast cancer.


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