<abstract xmlns="http://www.w3.org/1999/xhtml"><p> Background. The blood-brain barrier represents the selective diffusion barrier at the level of the cerebral microvascular endothelium. Other functions of blood-brain barrier include transport, signaling and osmoregulation. Endothelial cells interact with surrounding astrocytes, pericytes and neurons. These interactions are crucial to the development, structural integrity and function of the cerebral microvascular endothelium. Dysfunctional blood-brain barrier has been associated with pathologies such as acute stroke, tumors, inflammatory and neurodegenerative diseases. </p><p>Conclusions. Blood-brain barrier permeability can be evaluated in vivo by perfusion computed tomography - an efficient diagnostic method that involves the sequential acquisition of tomographic images during the intravenous administration of iodinated contrast material. The major clinical applications of perfusion computed tomography are in acute stroke and in brain tumor imaging.</p></abstract>

Background. The blood-brain barrier represents the selective diffusion barrier at the level of the cerebral microvascular endothelium. Other functions of blood-brain barrier include transport, signaling and osmoregulation. Endothelial cells interact with surrounding astrocytes, pericytes and neurons. These interactions are crucial to the development, structural integrity and function of the cerebral microvascular endothelium. Dysfunctional blood-brain barrier has been associated with pathologies such as acute stroke, tumors, inflammatory and neurodegenerative diseases. Conclusions. Blood-brain barrier permeability can be evaluated in vivo by perfusion computed tomography - an efficient diagnostic method that involves the sequential acquisition of tomographic images during the intravenous administration of iodinated contrast material. The major clinical applications of perfusion computed tomography are in acute stroke and in brain tumor imaging.

Blood-brain barrier permeability imaging using perfusion computed tomography

Institute of Radiology, University Medical Centre Ljubljana, Slovenia

Department of Neuroradiology, Eberhard Karls University, Tubingen, Germany

Radiology and Oncology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Blood-brain barrier permeability imaging using perfusion computed tomography"}

Background. The blood-brain barrier represents the selective diffusion barrier at the level of the cerebral microvascular endothelium. Other functions of...

Blood-brain barrier permeability imaging using perfusion computed tomography

Published Online: Mar 25, 2015

Page range: 107 - 114

Received: Dec 02, 2013

Accepted: Mar 02, 2014

DOI: https://doi.org/10.2478/raon-2014-0029

Keywords
blood-brain barrier, permeability imaging, computed tomography, perfusion CT

© by Jernej Avsenik

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Blood-brain barrier permeability imaging using perfusion computed tomography

Published Online: Mar 25, 2015

Page range: 107 - 114

Received: Dec 02, 2013

Accepted: Mar 02, 2014

DOI: https://doi.org/10.2478/raon-2014-0029

Keywordsblood-brain barrier, permeability imaging, computed tomography, perfusion CT

© by Jernej Avsenik

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
blood-brain barrier, permeability imaging, computed tomography, perfusion CT