<abstract xmlns="http://www.w3.org/1999/xhtml"> Background. Individual radiosensitivity has a crucial impact on radiotherapy related side effects. Our aim was to study a breast cancer collective for its variation of individual radiosensitivity depending on the patients’ age. Materials and methods. Peripheral blood samples were obtained from 129 individuals. Individual radiosensitivity in 67 breast cancer patients and 62 healthy individuals was estimated by 3-color fluorescence in situ hybridization. Results. Breast cancer patients were distinctly more radiosensitive compared to healthy controls. A subgroup of 9 rather radiosensitive and 9 rather radio-resistant patients was identified. A subgroup of patients aged between 40 and 50 was distinctly more radiosensitive than younger or older patients. Conclusions. In the breast cancer collective a distinct resistant and sensitive subgroup is identified, which could be subject for treatment adjustment. Preliminary results indicate that especially in the range of age 40 to 50 patients with an increased radiosensitivity are more frequent and may have an increased risk to suffer from therapy related side effects.</abstract>

Background. Individual radiosensitivity has a crucial impact on radiotherapy related side effects. Our aim was to study a breast cancer collective for its variation of individual radiosensitivity depending on the patients’ age. Materials and methods. Peripheral blood samples were obtained from 129 individuals. Individual radiosensitivity in 67 breast cancer patients and 62 healthy individuals was estimated by 3-color fluorescence in situ hybridization. Results. Breast cancer patients were distinctly more radiosensitive compared to healthy controls. A subgroup of 9 rather radiosensitive and 9 rather radio-resistant patients was identified. A subgroup of patients aged between 40 and 50 was distinctly more radiosensitive than younger or older patients. Conclusions. In the breast cancer collective a distinct resistant and sensitive subgroup is identified, which could be subject for treatment adjustment. Preliminary results indicate that especially in the range of age 40 to 50 patients with an increased radiosensitivity are more frequent and may have an increased risk to suffer from therapy related side effects.

Individual radiosensitivity in a breast cancer collective is changed with the patients’ age

Department of Radiation Oncology of the University Hospitals and Friedrich-Alexander-University of Erlangen-Nürnberg, Erlangen, Germany

Radiology and Oncology

Background. Individual radiosensitivity has a crucial impact on radiotherapy related side effects. Our aim was to study a breast cancer collective for its...

Individual radiosensitivity in a breast cancer collective is changed with the patients’ age

Published Online: Jan 22, 2014

Page range: 80 - 86

DOI: https://doi.org/10.2478/raon-2013-0061

Keywords
individual radiosensitivity, chromosomal aberrations, age, fluorescence in situ hybridization, radiotherapy, breast cancer

This content is open access.

Individual radiosensitivity in a breast cancer collective is changed with the patients’ age

Published Online: Jan 22, 2014

Page range: 80 - 86

DOI: https://doi.org/10.2478/raon-2013-0061

Keywordsindividual radiosensitivity, chromosomal aberrations, age, fluorescence in situ hybridization, radiotherapy, breast cancer

This content is open access.

Keywords
individual radiosensitivity, chromosomal aberrations, age, fluorescence in situ hybridization, radiotherapy, breast cancer