<abstract xmlns="http://www.w3.org/1999/xhtml"> Background. RCC accounts for only 2-3% of all cancers. Due to its’ non-specific symptoms disease is often diagnosed in advanced stage. Disseminated RCC frequently produces bone metastases that are almost always highly destructive, hyper vascularized and purely osteolytic. Case report. In this article we describe a case of a 71-year old male patient with disseminated osteoblastic bone metastases from renal cell carcinoma (RCC), and present a short review of published literature reporting cases of osteoblastic bone metastases from RCC. Our patient presented with thoracic pain aggravated by movement. He was diagnosed with predominantly osteoblastic bone metastases in the skeleton of thoracic and lumbar vertebra along with metastases in iliac bones, ribs, humerus and clavicles. Initially, origin of bone metastases was unknown, but later a small tumor in patient’s right kidney was identified. Microscopic evaluation of the open bone biopsy showed clear cell RCC with sarcomatoid differentiation. Conclusions. Although, due to its’ rarity, RCC is not included in the primary differential diagnosis in patients with osteoblastic metastases, such rare cases suggest that RCC may be considered in the diagnosis when there no other primary tumor is found</abstract>

Background. RCC accounts for only 2-3% of all cancers. Due to its’ non-specific symptoms disease is often diagnosed in advanced stage. Disseminated RCC frequently produces bone metastases that are almost always highly destructive, hyper vascularized and purely osteolytic. Case report. In this article we describe a case of a 71-year old male patient with disseminated osteoblastic bone metastases from renal cell carcinoma (RCC), and present a short review of published literature reporting cases of osteoblastic bone metastases from RCC. Our patient presented with thoracic pain aggravated by movement. He was diagnosed with predominantly osteoblastic bone metastases in the skeleton of thoracic and lumbar vertebra along with metastases in iliac bones, ribs, humerus and clavicles. Initially, origin of bone metastases was unknown, but later a small tumor in patient’s right kidney was identified. Microscopic evaluation of the open bone biopsy showed clear cell RCC with sarcomatoid differentiation. Conclusions. Although, due to its’ rarity, RCC is not included in the primary differential diagnosis in patients with osteoblastic metastases, such rare cases suggest that RCC may be considered in the diagnosis when there no other primary tumor is found

Osteoblastic bone metastases from renal cell carcinoma

Clinical Radiology Institute, UMC Ljubljana, Ljubljana, Slovenia

Clinical Radiology Institute, UMC Ljubljana, Zaloška 7, 1000 Ljubljana, Slovenia. Phone: +386 41 33 66 97

Clinical Department of Haematology, UMC Ljubljana, Ljubljana, Slovenia

Sector of Medical Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia

Department of Pathology, Institute of Oncology Ljubljana, Ljubljana, Slovenia

Radiology and Oncology

This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

{"article-title":"Osteoblastic bone metastases from renal cell carcinoma"}

Background. RCC accounts for only 2-3% of all cancers. Due to its’ non-specific symptoms disease is often diagnosed in advanced stage. Disseminated RCC...

Osteoblastic bone metastases from renal cell carcinoma

Published Online: Jul 10, 2014

Page range: 243 - 246

Received: Mar 07, 2013

Accepted: May 12, 2013

DOI: https://doi.org/10.2478/raon-2013-0034

Keywords
renal cell carcinoma, osteoblastic bone metasatases

© by Vladka Salapura

This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Osteoblastic bone metastases from renal cell carcinoma

Published Online: Jul 10, 2014

Page range: 243 - 246

Received: Mar 07, 2013

Accepted: May 12, 2013

DOI: https://doi.org/10.2478/raon-2013-0034

Keywordsrenal cell carcinoma, osteoblastic bone metasatases

© by Vladka Salapura

This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Keywords
renal cell carcinoma, osteoblastic bone metasatases