<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>The goal of the study was to test the ability of a representative of the 1,4-DHP group — glutapyrone to protect DNA against damage. The compound increased the concentration of the hydroxyl radicals produced in the Fenton reaction, it did not scavenge peroxynitrite and did not protect plasmid DNA against damage by products of the Fenton reaction. On the other hand, the compound protected HeLa cells against damage by peroxinitrite and B-lymphocytes against DNA damage in the conditions of oxidative stress induced by transfection of the Tat protein derived from the HIV virus. It is supposed that glutapyrone mobilises DNA repair systems.</p>
</abstract>

The goal of the study was to test the ability of a representative of the 1,4-DHP group — glutapyrone to protect DNA against damage. The compound increased the concentration of the hydroxyl radicals produced in the Fenton reaction, it did not scavenge peroxynitrite and did not protect plasmid DNA against damage by products of the Fenton reaction. On the other hand, the compound protected HeLa cells against damage by peroxinitrite and B-lymphocytes against DNA damage in the conditions of oxidative stress induced by transfection of the Tat protein derived from the HIV virus. It is supposed that glutapyrone mobilises DNA repair systems.

Study of Impact of a 1,4-DHP Derivative Glutapyrone on DNA Using <italic>In Vitro</italic> Tests

Institute of Biology of the University of Latvia

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

This work is licensed under the Creative Commons Attribution 4.0 International License.

Study of Impact of a 1,4-DHP Derivative Glutapyrone on DNA Using  Tests

The goal of the study was to test the ability of a representative of the 1,4-DHP group — glutapyrone to protect DNA against damage. The compound increased the...

Study of Impact of a 1,4-DHP Derivative Glutapyrone on DNA Using In Vitro Tests

Published Online: Mar 09, 2023

Page range: 49 - 52

Received: Apr 25, 2022

Accepted: Nov 10, 2022

DOI: https://doi.org/10.2478/prolas-2023-0006

Keywords
1,4-dihydropyridine, glutapyrone, Fenton reaction, Comet assay, Tat protein

© 2023 Elīna Ļeonova et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Study of Impact of a 1,4-DHP Derivative Glutapyrone on DNA Using In Vitro Tests

Published Online: Mar 09, 2023

Page range: 49 - 52

Received: Apr 25, 2022

Accepted: Nov 10, 2022

DOI: https://doi.org/10.2478/prolas-2023-0006

Keywords1,4-dihydropyridine, glutapyrone, Fenton reaction, Comet assay, Tat protein

© 2023 Elīna Ļeonova et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Keywords
1,4-dihydropyridine, glutapyrone, Fenton reaction, Comet assay, Tat protein