<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Dysregulation of the cell cycle is an important factor in a potentially malignant oral disorder. There have not been many studies on the role of the cell cycle regulator p27 in oral non-homogenous leukoplakia. The aim of our study was to characterise the p27 protein in homogenous and non-homogenous oral leukoplakias (OL), in comparison with healthy mucosa and squamous cell carcinoma tissues. The current study included 25 patients with OL, 15 cases with oral squamous cell carcinoma, and 15 samples of healthy oral mucosa, both as comparison groups. Immunohistochemical p27 antigen expression was determined by a standard EnView imaging system. The expression level of p27 in nodular and verrucous leukoplakia was lower than in homogenous OL but higher than in erythroleukoplakia. There was a statistically significant difference (<italic>p</italic> &lt; 0.05) between the expression of p27 in healthy mucosa and homogenous OL. There was a significantly lower amount of p27 positive cells in oral cancer than in OL (<italic>p</italic> &lt; 0.0001); however, its intracytoplasmic presence was diagnosed. Our study proved the instability of p27 protein and its dual nature in non-homogenous OL and OSCC, and therefore, it can be used as a predictive marker for the clinical course of these conditions.</p>
</abstract>

Dysregulation of the cell cycle is an important factor in a potentially malignant oral disorder. There have not been many studies on the role of the cell cycle regulator p27 in oral non-homogenous leukoplakia. The aim of our study was to characterise the p27 protein in homogenous and non-homogenous oral leukoplakias (OL), in comparison with healthy mucosa and squamous cell carcinoma tissues. The current study included 25 patients with OL, 15 cases with oral squamous cell carcinoma, and 15 samples of healthy oral mucosa, both as comparison groups. Immunohistochemical p27 antigen expression was determined by a standard EnView imaging system. The expression level of p27 in nodular and verrucous leukoplakia was lower than in homogenous OL but higher than in erythroleukoplakia. There was a statistically significant difference (p < 0.05) between the expression of p27 in healthy mucosa and homogenous OL. There was a significantly lower amount of p27 positive cells in oral cancer than in OL (p < 0.0001); however, its intracytoplasmic presence was diagnosed. Our study proved the instability of p27 protein and its dual nature in non-homogenous OL and OSCC, and therefore, it can be used as a predictive marker for the clinical course of these conditions.

Characteristics of the dual nature of the p27 protein in oral leukoplakias and cancer

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Dysregulation of the cell cycle is an important factor in a potentially malignant oral disorder. There have not been many studies on the role of the cell cycle...

Characteristics of the dual nature of the p27 protein in oral leukoplakias and cancer

Published Online: Dec 10, 2022

Page range: 665 - 673

DOI: https://doi.org/10.2478/prolas-2022-0102

Keywords
oral precancers, oral carcinoma, CDKN1B, tumour suppressor gene p27, oncogene p27

© 2022 Madara Dzudzilo et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Characteristics of the dual nature of the p27 protein in oral leukoplakias and cancer

Published Online: Dec 10, 2022

Page range: 665 - 673

DOI: https://doi.org/10.2478/prolas-2022-0102

Keywordsoral precancers, oral carcinoma, CDKN1B, tumour suppressor gene p27, oncogene p27

© 2022 Madara Dzudzilo et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
oral precancers, oral carcinoma, CDKN1B, tumour suppressor gene p27, oncogene p27