<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>This study compared the reference intervals (RI) of B12 vitamin concentration in blood found in the literature with RIs extracted from data accumulated from a large number of patients by E. Gulbis Laboratory in Latvia. This paper investigated and demonstrated the possibility of using large amounts of random patient data to establish the RI for clinical laboratory tests. The blood level of B12 vitamin was selected as the model system for this study. The study used blind data for B12 blood level measurements from 132 379 patients accumulated in E. Gulbis Laboratory over a period of 15 years. In order to establish the reference intervals, the frequency distribution of log transformed B12 values was fit to a Gaussian distribution. The established B12 reference interval of 196 pg/ml and 942 pg/ml was found to be in good agreement with RIs reported elsewhere.</p>
</abstract>

This study compared the reference intervals (RI) of B12 vitamin concentration in blood found in the literature with RIs extracted from data accumulated from a large number of patients by E. Gulbis Laboratory in Latvia. This paper investigated and demonstrated the possibility of using large amounts of random patient data to establish the RI for clinical laboratory tests. The blood level of B12 vitamin was selected as the model system for this study. The study used blind data for B12 blood level measurements from 132 379 patients accumulated in E. Gulbis Laboratory over a period of 15 years. In order to establish the reference intervals, the frequency distribution of log transformed B12 values was fit to a Gaussian distribution. The established B12 reference interval of 196 pg/ml and 942 pg/ml was found to be in good agreement with RIs reported elsewhere.

Extraction of B12 Reference Intervals from a Large Amount of General Patient Data

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

This study compared the reference intervals (RI) of B12 vitamin concentration in blood found in the literature with RIs extracted from data accumulated from a...

Extraction of B12 Reference Intervals from a Large Amount of General Patient Data

Published Online: Jul 23, 2022

Page range: 333 - 337

Received: Jan 21, 2022

Accepted: Jun 07, 2022

DOI: https://doi.org/10.2478/prolas-2022-0050

Keywords
B12 vitamin, large patient data, method of calculating reference interval, clinical analysis, B12 local reference interval

© 2022 Didzis Gavars et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Extraction of B12 Reference Intervals from a Large Amount of General Patient Data

Published Online: Jul 23, 2022

Page range: 333 - 337

Received: Jan 21, 2022

Accepted: Jun 07, 2022

DOI: https://doi.org/10.2478/prolas-2022-0050

KeywordsB12 vitamin, large patient data, method of calculating reference interval, clinical analysis, B12 local reference interval

© 2022 Didzis Gavars et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
B12 vitamin, large patient data, method of calculating reference interval, clinical analysis, B12 local reference interval