<abstract xmlns="http://www.w3.org/1999/xhtml"><p>The article discusses the possible relationships between intestinal microbiota and the therapeutic efficacy of 5-aminosalicylic acid (5-ASA) in inflammatory bowel diseases. Intestinal microbiota may be involved in 5-ASA enzymatic biotransformation, but the metabolism of drugs by the intestinal microbiota has been studied in less detail, and little is known about the relationships between anti-inflammatory efficacy of 5-ASA with bacterial viability, quantity and activity. It remains unclear whether 5-ASA affects the microbiota depending on the different segments of gastrointestinal tract. Drugs and diet can both improve and worsen the composition of the intestinal microbiota. However, it is not known whether drugs affect the intestinal microbiota regardless of diet. Further research is needed to answer these questions.</p></abstract>

The article discusses the possible relationships between intestinal microbiota and the therapeutic efficacy of 5-aminosalicylic acid (5-ASA) in inflammatory bowel diseases. Intestinal microbiota may be involved in 5-ASA enzymatic biotransformation, but the metabolism of drugs by the intestinal microbiota has been studied in less detail, and little is known about the relationships between anti-inflammatory efficacy of 5-ASA with bacterial viability, quantity and activity. It remains unclear whether 5-ASA affects the microbiota depending on the different segments of gastrointestinal tract. Drugs and diet can both improve and worsen the composition of the intestinal microbiota. However, it is not known whether drugs affect the intestinal microbiota regardless of diet. Further research is needed to answer these questions.

The Effect of 5-Aminosalicylic Acid on Intestinal Microbiota

Department of Microbiology and Biotechnology

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

{"article-title":"The Effect of 5-Aminosalicylic Acid on Intestinal Microbiota"}

The article discusses the possible relationships between intestinal microbiota and the therapeutic efficacy of 5-aminosalicylic acid (5-ASA) in inflammatory...

The Effect of 5-Aminosalicylic Acid on Intestinal Microbiota

Published Online: May 11, 2020

Page range: 53 - 57

Received: Jan 29, 2020

Accepted: Feb 25, 2020

DOI: https://doi.org/10.2478/prolas-2020-0008

Keywords
5-ASA, inflammatory bowel diseases, microbiota, inflammation

© 2020 Vanda Sargautiene et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

The Effect of 5-Aminosalicylic Acid on Intestinal Microbiota

Published Online: May 11, 2020

Page range: 53 - 57

Received: Jan 29, 2020

Accepted: Feb 25, 2020

DOI: https://doi.org/10.2478/prolas-2020-0008

Keywords5-ASA, inflammatory bowel diseases, microbiota, inflammation

© 2020 Vanda Sargautiene et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
5-ASA, inflammatory bowel diseases, microbiota, inflammation