<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Vitamin D deficiency is common and widespread globally. Vitamin D has an immunomodulatory effect, but it is still unclear whether its deficiency is associated with higher disease activity. The aim of this retrospective study was to determine the serum concentration of vitamin D in children with paediatric arthritis (juvenile idiopathic arthritis and reactive arthritis). Prevalence of hypo-vitaminosis D among 98 children with juvenile idiopathic arthritis and reactive arthritis was determined and association between serum concentration of vitamin D and disease activity markers was found. Prevalence of vitamin D deficiency among children included in this study was 69.07%. Children with juvenile idiopathic arthritis had a significantly lower vitamin D level than children with reactive arthritis. There was a statistically significant moderate negative correlation between serum concentration of vitamin D and patient age, as well as a weak negative correlation between vitamin D level and patient body mass index. The significant correlations found between vitamin D level and inflammatory markers indicate that further research on the role of vitamin D in disease activity is needed.</p></abstract>

Vitamin D deficiency is common and widespread globally. Vitamin D has an immunomodulatory effect, but it is still unclear whether its deficiency is associated with higher disease activity. The aim of this retrospective study was to determine the serum concentration of vitamin D in children with paediatric arthritis (juvenile idiopathic arthritis and reactive arthritis). Prevalence of hypo-vitaminosis D among 98 children with juvenile idiopathic arthritis and reactive arthritis was determined and association between serum concentration of vitamin D and disease activity markers was found. Prevalence of vitamin D deficiency among children included in this study was 69.07%. Children with juvenile idiopathic arthritis had a significantly lower vitamin D level than children with reactive arthritis. There was a statistically significant moderate negative correlation between serum concentration of vitamin D and patient age, as well as a weak negative correlation between vitamin D level and patient body mass index. The significant correlations found between vitamin D level and inflammatory markers indicate that further research on the role of vitamin D in disease activity is needed.

Level of 25-Hydroxyvitamin D in Pediatric Arthritis Patients

Children’s Clinical University Hospital

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

{"article-title":"Level of 25-Hydroxyvitamin D in Pediatric Arthritis Patients"}

Vitamin D deficiency is common and widespread globally. Vitamin D has an immunomodulatory effect, but it is still unclear whether its deficiency is associated...

Level of 25-Hydroxyvitamin D in Pediatric Arthritis Patients

Published Online: Nov 01, 2019

Page range: 425 - 432

Received: May 19, 2019

Accepted: Jun 17, 2019

DOI: https://doi.org/10.2478/prolas-2019-0068

Keywords
vitamin D, juvenile idiopathic arthritis, reactive arthritis

© 2019 Marta Laizāne et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Level of 25-Hydroxyvitamin D in Pediatric Arthritis Patients

Published Online: Nov 01, 2019

Page range: 425 - 432

Received: May 19, 2019

Accepted: Jun 17, 2019

DOI: https://doi.org/10.2478/prolas-2019-0068

Keywordsvitamin D, juvenile idiopathic arthritis, reactive arthritis

© 2019 Marta Laizāne et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
vitamin D, juvenile idiopathic arthritis, reactive arthritis