<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Colonisation of gastrointestinal tract by extended spectrum beta lactamase (ESBL)-producing Gram-negative bacteria is a source for infections. The present work is a prospective study in Latvia aimed to determine the role of two surgical profile wards in transmission of ESBL-producing bacteria. Differences between hospital wards were not analysed due to low number of patients. We have also determined a correlation between the duration of hospitalisation and risk of ESBL colonisation. Tests for ESBL-producing bacteria were made twice for 136 patients — upon admission and upon discharge from the hospital. Of them, 21 (15.4%) patients already were ESBL-positive at the time of admission and 115 (84.6%) patients were ESBL-negative. Upon discharge from hospital, 45 (33.1%) patients were ESBL-positive, one patient was ESBL-negative, and 25 (18.4%) of ESBL-positive cases had emerged during hospitalisation. In total, 46 (33.8%) from 136 patients were ESBL-positive and ESBL was positive in 51 bacterial isolates. On discharge from hospital, the newly acquired ESBL-positive bacterial isolates were <italic>K. pneumoniae</italic> (n = 18), <italic>E. coli</italic> (n = 7) and <italic>P. mirabilis</italic> (n = 3). The prevalence of ESBL-positive <italic>E. coli</italic> from all detected <italic>E. coli</italic> was 7.0% and from all <italic>Klebsiella</italic> spp. — 88.9% in gut flora. Analysis of patientassociated wound infections did not show correlation between the ESBL-producing gut microbiota and the bacterial species involved in wound infection.</p></abstract>

Colonisation of gastrointestinal tract by extended spectrum beta lactamase (ESBL)-producing Gram-negative bacteria is a source for infections. The present work is a prospective study in Latvia aimed to determine the role of two surgical profile wards in transmission of ESBL-producing bacteria. Differences between hospital wards were not analysed due to low number of patients. We have also determined a correlation between the duration of hospitalisation and risk of ESBL colonisation. Tests for ESBL-producing bacteria were made twice for 136 patients — upon admission and upon discharge from the hospital. Of them, 21 (15.4%) patients already were ESBL-positive at the time of admission and 115 (84.6%) patients were ESBL-negative. Upon discharge from hospital, 45 (33.1%) patients were ESBL-positive, one patient was ESBL-negative, and 25 (18.4%) of ESBL-positive cases had emerged during hospitalisation. In total, 46 (33.8%) from 136 patients were ESBL-positive and ESBL was positive in 51 bacterial isolates. On discharge from hospital, the newly acquired ESBL-positive bacterial isolates were K. pneumoniae (n = 18), E. coli (n = 7) and P. mirabilis (n = 3). The prevalence of ESBL-positive E. coli from all detected E. coli was 7.0% and from all Klebsiella spp. — 88.9% in gut flora. Analysis of patientassociated wound infections did not show correlation between the ESBL-producing gut microbiota and the bacterial species involved in wound infection.

Prevalence of Extended Spectrum Beta Lactamase Producing Bacteria in Two Surgical Wards of a General Hospital

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Colonisation of gastrointestinal tract by extended spectrum beta lactamase (ESBL)-producing Gram-negative bacteria is a source for infections. The present work...

Prevalence of Extended Spectrum Beta Lactamase Producing Bacteria in Two Surgical Wards of a General Hospital

Published Online: Feb 14, 2019

Page range: 40 - 46

Received: May 16, 2018

Accepted: Nov 02, 2018

DOI: https://doi.org/10.2478/prolas-2019-0006

Keywords
ESBL, bacterial colonisation, gut microbiota

© 2019 Baiba Zandersone et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Prevalence of Extended Spectrum Beta Lactamase Producing Bacteria in Two Surgical Wards of a General Hospital

Published Online: Feb 14, 2019

Page range: 40 - 46

Received: May 16, 2018

Accepted: Nov 02, 2018

DOI: https://doi.org/10.2478/prolas-2019-0006

KeywordsESBL, bacterial colonisation, gut microbiota

© 2019 Baiba Zandersone et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
ESBL, bacterial colonisation, gut microbiota