<abstract xmlns="http://www.w3.org/1999/xhtml"><p> Sepsis is characterised by massive inflammatory response, which can affect vascular function. This study was designed to assess the impact of early severe sepsis and septic shock on arterial stiffness and the relationship of this impact to outcome. Twelve patients with severe sepsis and 22 with septic shock were included in the study. We measured carotid to femoral and carotid to radial pulse wave velocity (PWV), an index of aortic and brachial arterial stiffness, in patients with early severe sepsis and septic shock within 24 hours of admission to intensive care unit and repeatedly after 48 hours. No difference was observed between patients with severe sepsis and septic shock regarding carotid to femoral PWV (11.7 ± 2.2 vs. 11.3 ± 3.6 m/s) and carotid to radial PWV (12.0 ± 3.8 vs. 9.5 ± 2.2 m/s). On 48 hour follow-up, PWV did not significantly differ between survivors and non-survivors. A positive, similar correlation occurred between PWV and pulse pressure in all patients (r = 0.35, p = 0.05), and there was a negative correlation between PWV and C-reactive protein levels (r = -0.43, p = 0.04). In conclusion, PWV is not affected by disease severity or prognosis.</p></abstract>

Sepsis is characterised by massive inflammatory response, which can affect vascular function. This study was designed to assess the impact of early severe sepsis and septic shock on arterial stiffness and the relationship of this impact to outcome. Twelve patients with severe sepsis and 22 with septic shock were included in the study. We measured carotid to femoral and carotid to radial pulse wave velocity (PWV), an index of aortic and brachial arterial stiffness, in patients with early severe sepsis and septic shock within 24 hours of admission to intensive care unit and repeatedly after 48 hours. No difference was observed between patients with severe sepsis and septic shock regarding carotid to femoral PWV (11.7 ± 2.2 vs. 11.3 ± 3.6 m/s) and carotid to radial PWV (12.0 ± 3.8 vs. 9.5 ± 2.2 m/s). On 48 hour follow-up, PWV did not significantly differ between survivors and non-survivors. A positive, similar correlation occurred between PWV and pulse pressure in all patients (r = 0.35, p = 0.05), and there was a negative correlation between PWV and C-reactive protein levels (r = -0.43, p = 0.04). In conclusion, PWV is not affected by disease severity or prognosis.

Arterial Stiffness Measured by Pulse Wave Velocity in Patients with Early Sepsis / Artēriju Cietība Un Pulsa Viļņa Izplatīšanās Ātrums Pacientiem Ar Agrīnu Sepsi

Department of Anaesthesiology, Hospital of Traumatology and Orthopaedics, Duntes iela 22, Rīga LV-1013, LATVIA

Department of Anaesthesiology and Reanimatology, Rīga Stradiòð University, Dzirciema iela16, Rīga, LATVIA

Institute of Atomic Physics and Spectroscopy, University of Latvia, Duntes iela 4, Rīga LV-1586, LATVIA

Department of Anaesthesiology and Cardiac Surgery, Pauls Stradiňš Clinical University Hospital, Pilsoņu iela 13, Rīga, LATVIA

Department of Anaesthesiology and Reanimatology, Rīga Stradiňš University, Dzirciema iela16, Rīga, LATVIA

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Sepsis is characterised by massive inflammatory response, which can affect vascular function. This study was designed to assess the impact of early severe...

Arterial Stiffness Measured by Pulse Wave Velocity in Patients with Early Sepsis / Artēriju Cietība Un Pulsa Viļņa Izplatīšanās Ātrums Pacientiem Ar Agrīnu Sepsi

Published Online: Dec 30, 2014

Page range: 237 - 241

Received: Aug 23, 2014

DOI: https://doi.org/10.2478/prolas-2014-0030

© by Sigita Kazūne

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.