<abstract xmlns="http://www.w3.org/1999/xhtml">We describe the clinical course of a patient who developed high-grade lymphoma during immunosuppression treatment with cyclosporine A, following liver transplantation. After anti-neoplastic polychemotherapy treatment, the remission of lymphoma was confirmed and maintained for over four years.The patient, a 27 year old female had liver transplantation at the age of 17, due to acute liver failure, caused by non-diagnosed Wilson disease. Nearly seven years post-transplantation, the patient was diagnosed with non-Hodgkin B-cell lymphoma (NHBCL), potentially induced by Cephalosporin A therapy. After the treatment with rituximab and CHOP therapy (r-CHOP protocol), remission was determined using computer tomography. Remission is maintained to date.A review of reported cases of post-transplant lymphoproliferative disorders (PTLDs) in liver transplanted (LT) patients showed that the onset of PTLDs is the highest in the first year after transplantation. In addition, remission rates of NHBCL in LT patients are not much elaborated in the literature. It is our opinion that the presented case is rare, both from the aspect of timeline of occurrence of the PTLD and the achieved remission, using r-CHOP protocol.</abstract>

We describe the clinical course of a patient who developed high-grade lymphoma during immunosuppression treatment with cyclosporine A, following liver transplantation. After anti-neoplastic polychemotherapy treatment, the remission of lymphoma was confirmed and maintained for over four years.The patient, a 27 year old female had liver transplantation at the age of 17, due to acute liver failure, caused by non-diagnosed Wilson disease. Nearly seven years post-transplantation, the patient was diagnosed with non-Hodgkin B-cell lymphoma (NHBCL), potentially induced by Cephalosporin A therapy. After the treatment with rituximab and CHOP therapy (r-CHOP protocol), remission was determined using computer tomography. Remission is maintained to date.A review of reported cases of post-transplant lymphoproliferative disorders (PTLDs) in liver transplanted (LT) patients showed that the onset of PTLDs is the highest in the first year after transplantation. In addition, remission rates of NHBCL in LT patients are not much elaborated in the literature. It is our opinion that the presented case is rare, both from the aspect of timeline of occurrence of the PTLD and the achieved remission, using r-CHOP protocol.

Remission of Late-Onset Post-Liver Transplantation Non-Hodgkin Lymphoma

University Clinic for Gastroenterohepatology, Ss. Cyril and Methodius University

University Clinic for Haematology, Ss. Cyril and Methodius University

Centre for Regional Policy Research and Cooperation “Studiorum”

PRILOZI

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

{"article-title":"Remission of Late-Onset Post-Liver Transplantation Non-Hodgkin Lymphoma"}

We describe the clinical course of a patient who developed high-grade lymphoma during immunosuppression treatment with cyclosporine A, following liver...

Remission of Late-Onset Post-Liver Transplantation Non-Hodgkin Lymphoma

Published Online: May 31, 2019

Page range: 67 - 71

DOI: https://doi.org/10.2478/prilozi-2019-0005

Keywords
liver, transplants, lymphoma, Non-Hodgkin, immunosuppression

© 2019 Kalina Grivcheva Stardelova et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Remission of Late-Onset Post-Liver Transplantation Non-Hodgkin Lymphoma

Published Online: May 31, 2019

Page range: 67 - 71

DOI: https://doi.org/10.2478/prilozi-2019-0005

Keywordsliver, transplants, lymphoma, Non-Hodgkin, immunosuppression

© 2019 Kalina Grivcheva Stardelova et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
liver, transplants, lymphoma, Non-Hodgkin, immunosuppression