Comparison of organs at risk doses between deep inspiration breath-hold and free-breathing techniques during radiotherapy of left-sided breast cancer: A Meta-Analysis

1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians. 2018;68(6):394-424. https://doi.org/10.3322/caac.2149230207593 Search in Google Scholar

2. Ferlay J, Colombet M, Soerjomataram I, et al. Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods. International Journal of Cancer. 2018;144(8):1941-1953. https://doi.org/10.1002/ijc.3193730350310 Search in Google Scholar

3. Lawler G and Leech M. Dose sparing potential of deep inspiration breath-hold technique for left breast cancer radiotherapy organs-at-risk. Anticancer Research. 2017;37:883-90. https://doi.org/10.21873/anticanres.1139428179347 Search in Google Scholar

4. Brownlee Z, Garg R, Listo M, Zavitsanos P, Wazer DE, Huber KE. Late complications of radiation therapy for breast cancer: evolution in techniques and risk over time. Gland Surg. 2018;7:371-8. https://doi.org/10.21037/gs.2018.01.05610758730175054 Search in Google Scholar

5. Macrie BD, Donnelly ED, Hayes JP, et al. A cost-effective technique for cardiac sparing with deep inspiration-breath hold (DIBH). Physica Medica. 2015;31:733-7. https://doi.org/10.1016/j.ejmp.2015.06.00626117242 Search in Google Scholar

6. Chi HC, Tsai CY, Tsai MM, Yeh CT, Lin KH. Roles of Long Noncoding RNAs in Recurrence and Metastasis of Radiotherapy-Resistant Cancer Stem Cells. International Journal of Molecular Sciences. 2017;18(9). https://doi.org/10.3390/ijms18091903561855228872613 Search in Google Scholar

7. Lomax ME, Folkes LK, O’Neill P. Biological consequences of radiation-induced DNA damage: relevance to radiotherapy. Clinical Oncology. 2013;25:578-85. https://doi.org/10.1016/j.clon.2013.06.00723849504 Search in Google Scholar

8. Zhu Q, Kirova YM, Cao L, Arsene-Henry A, Chen J. Cardiotoxicity associated with radiotherapy in breast cancer: A question-based review with current literatures. Cancer Treatment Reviews. 2018;68:9-15. https://doi.org/10.1016/j.ctrv.2018.03.00829777800 Search in Google Scholar

9. Taylor CW, Kirby AM. Cardiac Side-effects From Breast Cancer Radiotherapy. Clinical Oncology. 2015;27:621-9. https://doi.org/10.1016/j.clon.2015.06.00726133462 Search in Google Scholar

10. Poitevin-Chacón MA, Ramos-Prudencio R, Rumoroso-García JA, Rodríguez-Laguna A, Martínez-Robledo JC. Voluntary breath-hold reduces dose to organs at risk in radiotherapy of left-sided breast cancer. Reports of Practical Oncology and Radiotherapy. 2020;25:104-8. https://doi.org/10.1016/j.rpor.2019.12.016694066431908602 Search in Google Scholar

11. Hepp R, Ammerpohl M, Morgenstern C, et al. Deep inspiration breath-hold (DIBH) radiotherapy in left-sided breast cancer: Dosimetrical comparison and clinical feasibility in 20 patients. Strahlentherapie und Onkologie. 2015;191:710-6. https://doi.org/10.1007/s00066-015-0838-y Search in Google Scholar

12. Grantzau T, Thomsen MS, Væth M, Overgaard J. Risk of second primary lung cancer in women after radiotherapy for breast cancer. Radiotherapy and Oncology. 2014;111:366-73. https://doi.org/10.1016/j.radonc.2014.05.004 Search in Google Scholar

13. van den Bogaard VA, Ta BD, van der Schaaf A, et al. Validation and Modification of a Prediction Model for Acute Cardiac Events in Patients With Breast Cancer Treated With Radiotherapy Based on Three-Dimensional Dose Distributions to Cardiac Substructures. Journal of Clinical Oncology. 2017;35:1171-8. https://doi.org/10.1200/jco.2016.69.8480 Search in Google Scholar

14. Prunaretty J, Boisselier P, Aillères N, et al. Tracking, gating, free-breathing, which technique to use for lung stereotactic treatments? A dosimetric comparison. Reports of Practical Oncology and Radiotherapy. 2019;24:97-104. https://doi.org/10.1016/j.rpor.2018.11.003 Search in Google Scholar

15. Yu PC, Wu CJ, Tsai YL, et al. Dosimetric analysis of tangent-based volumetric modulated arc therapy with deep inspiration breath-hold technique for left breast cancer patients. Radiation Oncology. 2018;13:231. https://doi.org/10.1186/s13014-018-1170-3 Search in Google Scholar

16. Boda-Heggemann J, Knopf A-C, Simeonova A, et al. DIBH (Deep Inspiratory Breath Hold)-based radiotherapy – a clinical review. International Journal of Radiation Oncology Biology Physics. 2015;94. https://doi.org/10.1016/j.ijrobp.2015.11.049 Search in Google Scholar

17. Karpf D, Sakka M, Metzger M and Grabenbauer GG. Left breast irradiation with tangential intensity modulated radiotherapy (t-IMRT) versus tangential volumetric modulated arc therapy (t-VMAT): trade-offs between secondary cancer induction risk and optimal target coverage. Radiation Oncology. 2019;14:156. https://doi.org/10.1186/s13014-019-1363-4 Search in Google Scholar

18. Bergom C, Currey A, Desai N, Tai A, Strauss JB. Deep Inspiration Breath Hold: Techniques and Advantages for Cardiac Sparing During Breast Cancer Irradiation. Front Oncol. 2018;8:87. https://doi.org/10.3389/fonc.2018.00087 Search in Google Scholar

19. Wong JW, Sharpe MB, Jaffray DA, et al. The use of active breathing control (ABC) to reduce margin for breathing motion. International Journal of Radiation Oncology Biology Physics. 1999;44:911-9. https://doi.org/10.1016/s0360-3016(99)00056-5 Search in Google Scholar

20. Latty D, Stuart KE, Wang W, Ahern V. Review of deep inspiration breath-hold techniques for the treatment of breast cancer. Journal of Medical Radiation Sciences. 2015;62:74-81. https://doi.org/10.1002/jmrs.96436480926229670 Search in Google Scholar

21. Cao N, Kalet AM, Young LA, et al. Predictors of cardiac and lung dose sparing in DIBH for left breast treatment. Physica Medica. 2019;67:27-33. https://doi.org/10.1016/j.ejmp.2019.09.24031629280 Search in Google Scholar

22. Nissen HD, Appelt AL. Improved heart, lung and target dose with deep inspiration breath hold in a large clinical series of breast cancer patients. Radiotherapy and Oncology. 2013;106:28-32. https://doi.org/10.1016/j.radonc.2012.10.01623199652 Search in Google Scholar

23. Bartlett FR, Colgan RM, Carr K, et al. The UK HeartSpare Study: Randomised evaluation of voluntary deep-inspiratory breath-hold in women undergoing breast radiotherapy. Radiotherapy and Oncology. 2013;108:242-7. https://doi.org/10.1016/j.radonc.2013.04.02123726115 Search in Google Scholar

24. Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Medicine. 2009;6:e1000097. https://doi.org/10.1371/journal.pmed.1000097270759919621072 Search in Google Scholar

25. Takeshima N, Sozu T, Tajika A, Ogawa Y, Hayasaka Y, Furukawa TA. Which is more generalizable, powerful and interpretable in meta-analyses, mean difference or standardized mean difference? BMC Medical Research Methodology. 2014;14:30. https://doi.org/10.1186/1471-2288-14-30393684224559167 Search in Google Scholar

26. Faraone SV. Interpreting estimates of treatment effects: implications for managed care. Pharmacy and Therapeutics. 2008;33:700-11. Search in Google Scholar

27. Sterne J, Harbord R. Funnel Plots in Meta-analysis. Stata Journal. 2004;4:127-41. https://doi.org/10.1177/1536867X0400400204 Search in Google Scholar

28. Veronese N, Cereda E, Solmi M, et al. Inverse relationship between body mass index and mortality in older nursing home residents: a meta-analysis of 19,538 elderly subjects. Obesity Reviews. 2015;16:1001-15. https://doi.org/10.1111/obr.1230926252230 Search in Google Scholar

29. Aiello D, Borzì GR, Marino L, Umina V, Di Grazia AM. Comparison of deep inspiration breath hold and free breathing technique in left breast cancer irradiation: a dosimetric evaluation in 40 patients. Journal of Radiation Oncology. 2019;8:89-96. https://doi.org/10.1007/s13566-019-00381-3 Search in Google Scholar

30. Al-Hammadi N, Caparrotti P, Naim C, et al. Voluntary deep inspiration breath-hold reduces the heart dose without compromising the target volume coverage during radiotherapy for left-sided breast cancer. Radiology and Oncology. 2018;52:112-20. https://doi.org/10.1515/raon-2018-0008583908929520213 Search in Google Scholar

31. Bartlett FR, Colgan RM, Donovan EM, et al. The UK HeartSpare Study (Stage IB): Randomised comparison of a voluntary breath-hold technique and prone radiotherapy after breast conserving surgery. Radiotherapy and Oncology. 2015;114:66-72. https://doi.org/10.1016/j.radonc.2014.11.01825739317 Search in Google Scholar

32. Jagsi R, Griffith KA, Moran JM, et al. A Randomized Comparison of Radiation Therapy Techniques in the Management of Node-Positive Breast Cancer: Primary Outcomes Analysis. International Journal of Radiation Oncology Biology Physics. 2018;101:1149-58. https://doi.org/10.1016/j.ijrobp.2018.04.075693871830012527 Search in Google Scholar

33. Joo JH, Kim SS, Ahn SD, et al. Cardiac dose reduction during tangential breast irradiation using deep inspiration breath hold: A dose comparison study based on deformable image registration. Radiation Oncology. 2015;10. https://doi.org/10.1186/s13014-015-0573-7469610826715382 Search in Google Scholar

34. Kathpal M, Tinnel B, Sun K, et al. Deep inspiration breath hold with electromagnetic confirmation of chest wall position for adjuvant therapy of left-sided breast cancer: Technique and accuracy. Practical Radiation Oncology. 2016;6:e195-e202. https://doi.org/10.1016/j.prro.2015.12.00826922702 Search in Google Scholar

35. Kim A, Kalet AM, Cao N, et al. Effects of Preparatory Coaching and Home Practice for Deep Inspiration Breath Hold on Cardiac Dose for Left Breast Radiation Therapy. Clinical Oncology. 2018; 30: 571-7. https://doi.org/10.1016/j.clon.2018.04.00929773446 Search in Google Scholar

36. Mathieu D, Bedwani S, Mascolo-Fortin J, et al. Cardiac Sparing with Personalized Treatment Planning for Early-stage Left Breast Cancer. Cureus. 2020;12:e7247. https://doi.org/10.7759/cureus.7247715257932292662 Search in Google Scholar

37. Nguyen MH, Lavilla M, Kim JN, Fang LC. Cardiac sparing characteristics of internal mammary chain radiotherapy using deep inspiration breath hold for left-sided breast cancer. Radiation Oncology. 2018;13. https://doi.org/10.1186/s13014-018-1052-8598430129855325 Search in Google Scholar

38. Oechsner M, Düsberg M, Borm KJ, Combs SE, Wilkens JJ and Duma MN. Deep inspiration breath-hold for left-sided breast irradiation: Analysis of dose-mass histograms and the impact of lung expansion. Radiation Oncology. 2019;14. https://doi.org/10.1186/s13014-019-1293-1658258131215458 Search in Google Scholar

39. Ranger A, Dunlop A, Hutchinson K, et al. A Dosimetric Comparison of Breast Radiotherapy Techniques to Treat Locoregional Lymph Nodes Including the Internal Mammary Chain. Clinical Oncology. 2018;30:346-53. https://doi.org/10.1016/j.clon.2018.01.01729483041 Search in Google Scholar

40. Rochet N, Drake JI, Harrington K, et al. Deep inspiration breath-hold technique in left-sided breast cancer radiation therapy: Evaluating cardiac contact distance as a predictor of cardiac exposure for patient selection. Practical Radiation Oncology. 2015;5:e127-e34. https://doi.org/10.1016/j.prro.2014.08.00325413399 Search in Google Scholar

41. Sakka M, Kunzelmann L, Metzger M, Grabenbauer GG. Cardiac dose-sparing effects of deep-inspiration breath-hold in left breast irradiation : Is IMRT more beneficial than VMAT? Strahlentherapie und Onkologie. 2017;193:800-11. https://doi.org/10.1007/s00066-017-1167-028646251 Search in Google Scholar

42. Sripathi L, Ahlawat P, Simson D, et al. Cardiac dose reduction with deep-inspiratory breath hold technique of radiotherapy for left-sided breast cancer. Journal of Medical Physics. 2017;42:123-7. https://doi.org/10.4103/jmp.JMP_139_16561845728974856 Search in Google Scholar

43. Tamburella C, Guibert G, Cruz OS, Weber P, Tsousou P. A volumetric Modulated Arc Therapy (VMAT) combined with deep inspiration breath hold (DIBH) technique for adjuvant irradiation for left sided breast cancer. arXiv preprint arXiv:170606867. 2017.10.1016/j.ijrobp.2016.06.708 Search in Google Scholar

44. Wiant D, Wentworth S, Liu H, Sintay B. How important is a reproducible breath hold for deep inspiration breath hold breast radiation therapy? International Journal of Radiation Oncology Biology Physics. 2015;93:901-7. https://doi.org/10.1016/j.ijrobp.2015.06.01026530760 Search in Google Scholar

45. Yeung R, Conroy L, Long K, et al. Cardiac dose reduction with deep inspiration breath hold for left-sided breast cancer radiotherapy patients with and without regional nodal irradiation. Radiation Oncology. 2015;10:200. https://doi.org/10.1186/s13014-015-0511-8457877926391237 Search in Google Scholar

46. Mast ME, van Kempen-Harteveld L, Heijenbrok MW, et al. Left-sided breast cancer radiotherapy with and without breath-hold: does IMRT reduce the cardiac dose even further? Radiotherapy and Oncology. 2013;108:248-53. https://doi.org/10.1016/j.radonc.2013.07.01724044804 Search in Google Scholar

47. Osman SOS, Hol S, Poortmans PM, Essers M. Volumetric modulated arc therapy and breath-hold in image-guided locoregional left-sided breast irradiation. Radiotherapy and Oncology. 2014;112:17-22. https://doi.org/10.1016/j.radonc.2014.04.00424825176 Search in Google Scholar

48. Pham TT, Ward R, Latty D, et al. Left-sided breast cancer loco-regional radiotherapy with deep inspiration breath-hold: Does volumetric-modulated arc radiotherapy reduce heart dose further compared with tangential intensity-modulated radiotherapy? Journal of Medical Imaging and Radiation Oncology. 2016;60:545-53. https://doi.org/10.1111/1754-9485.1245927094588 Search in Google Scholar

49. Sakka M, Kunzelmann L, Metzger M, Grabenbauer GG. Cardiac dose-sparing effects of deep-inspiration breath-hold in left breast irradiation. Strahlentherapie und Onkologie. 2017;193:800-11.10.1007/s00066-017-1167-028646251 Search in Google Scholar