<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Today, to establish a diagnosis, the patient must undergo a biopsy followed by histopathological diagnosis, which causes unnecessary cost, patient trauma, and time delay to obtain a diagnosis. However, the metastases can be discovered by diffuse reflectance spectroscopy, which is a simple method that investigates the light distribution within tissue. The theme of this paper is the use of diffuse reflectance spectroscopy (DRS) to determine the optical spectrum of hamster specimen’s tissue and to differentiate biological changes due to laser irradiation (scattering, and cell changes) under the skin. DRS measurements were made on healthy and malignant tissue to diagnose the stages of cancer formation using a fiber-optic probe. The results show that malignant tissue is characterized by a significant decrease in diffuse reflectance spectrum compared to normal tissue.</p></abstract>

Today, to establish a diagnosis, the patient must undergo a biopsy followed by histopathological diagnosis, which causes unnecessary cost, patient trauma, and time delay to obtain a diagnosis. However, the metastases can be discovered by diffuse reflectance spectroscopy, which is a simple method that investigates the light distribution within tissue. The theme of this paper is the use of diffuse reflectance spectroscopy (DRS) to determine the optical spectrum of hamster specimen’s tissue and to differentiate biological changes due to laser irradiation (scattering, and cell changes) under the skin. DRS measurements were made on healthy and malignant tissue to diagnose the stages of cancer formation using a fiber-optic probe. The results show that malignant tissue is characterized by a significant decrease in diffuse reflectance spectrum compared to normal tissue.

Diffuse reflectance spectroscopy for identification of carcinogen transformation stages in skin tissue

Medical Physics, Biomedical Photonics Laboratory

Higher Institute for Laser Research and Applications

Department of Laser Physics and Technology, Higher Institute for Laser Research and Applications

Polish Journal of Medical Physics and Engineering

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Today, to establish a diagnosis, the patient must undergo a biopsy followed by histopathological diagnosis, which causes unnecessary cost, patient trauma, and...

Diffuse reflectance spectroscopy for identification of carcinogen transformation stages in skin tissue

Published Online: Aug 28, 2019

Page range: 141 - 147

Received: Sep 20, 2018

Accepted: May 08, 2019

DOI: https://doi.org/10.2478/pjmpe-2019-0019

Keywords
optical, spectrum, diffuse reflectance spectroscopy, healthy, malignant tissue

© 2019 Kawthar Shurrab et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Diffuse reflectance spectroscopy for identification of carcinogen transformation stages in skin tissue

Published Online: Aug 28, 2019

Page range: 141 - 147

Received: Sep 20, 2018

Accepted: May 08, 2019

DOI: https://doi.org/10.2478/pjmpe-2019-0019

Keywordsoptical, spectrum, diffuse reflectance spectroscopy, healthy, malignant tissue

© 2019 Kawthar Shurrab et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
optical, spectrum, diffuse reflectance spectroscopy, healthy, malignant tissue