<abstract xmlns="http://www.w3.org/1999/xhtml">103Pd seed is being used for prostate brachytherapy. Additionally, the dose enhancement effect of gold nanoparticles (GNP) has been reported in previous studies. The aim of this study was to characterize the dosimetric effect of gold nanoparticles in brachytherapy with a 103Pd source. Two brachytherapy seeds including 103 Pd source was simulated using MCNPX Monte Carlo code. The seeds’ models were validated by comparing the MC with reported results. Then, GNPs (10 nm in diameter) with a concentration of 7mg Au/g were simulated uniformly inside the prostate of a humanoid computational phantom. Additionally, the dose enhancement factor (DEF) of nanoparticles was calculated for both modeled brachytherapy seeds. A good agreement was found between the MC calculated and the reported dosimetric parameters. For both seeds, an average DEF of 23% was obtained in tumor volume for prostate brachytherapy. The application of GNPs in conjunction with 103Pd seed in brachytherapy can enhance the delivered dose to the tumor and consequently leads to better treatment outcome.</abstract>

103Pd seed is being used for prostate brachytherapy. Additionally, the dose enhancement effect of gold nanoparticles (GNP) has been reported in previous studies. The aim of this study was to characterize the dosimetric effect of gold nanoparticles in brachytherapy with a 103Pd source. Two brachytherapy seeds including 103 Pd source was simulated using MCNPX Monte Carlo code. The seeds’ models were validated by comparing the MC with reported results. Then, GNPs (10 nm in diameter) with a concentration of 7mg Au/g were simulated uniformly inside the prostate of a humanoid computational phantom. Additionally, the dose enhancement factor (DEF) of nanoparticles was calculated for both modeled brachytherapy seeds. A good agreement was found between the MC calculated and the reported dosimetric parameters. For both seeds, an average DEF of 23% was obtained in tumor volume for prostate brachytherapy. The application of GNPs in conjunction with 103Pd seed in brachytherapy can enhance the delivered dose to the tumor and consequently leads to better treatment outcome.

A Monte Carlo study on the radio-sensitization effect of gold nanoparticles in brachytherapy of prostate by 103Pd seeds

Polish Journal of Medical Physics and Engineering

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

A Monte Carlo study on the radio-sensitization effect of gold nanoparticles in brachytherapy of prostate by Pd seeds

103Pd seed is being used for prostate brachytherapy. Additionally, the dose enhancement effect of gold nanoparticles (GNP) has been reported in previous...

A Monte Carlo study on the radio-sensitization effect of gold nanoparticles in brachytherapy of prostate by ¹⁰³Pd seeds

Published Online: Jun 18, 2019

Page range: 87 - 92

Received: Sep 29, 2018

Accepted: Mar 07, 2019

DOI: https://doi.org/10.2478/pjmpe-2019-0012

Keywords
Pd, prostate cancer, brachytherapy, Monte Carlo, gold nanoparticle

© 2019 Amir Ghasemi Jangjoo et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

A Monte Carlo study on the radio-sensitization effect of gold nanoparticles in brachytherapy of prostate by 103Pd seeds

Published Online: Jun 18, 2019

Page range: 87 - 92

Received: Sep 29, 2018

Accepted: Mar 07, 2019

DOI: https://doi.org/10.2478/pjmpe-2019-0012

KeywordsPd, prostate cancer, brachytherapy, Monte Carlo, gold nanoparticle

© 2019 Amir Ghasemi Jangjoo et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

A Monte Carlo study on the radio-sensitization effect of gold nanoparticles in brachytherapy of prostate by ¹⁰³Pd seeds

Keywords
Pd, prostate cancer, brachytherapy, Monte Carlo, gold nanoparticle