<abstract xmlns="http://www.w3.org/1999/xhtml"><p>The aim of this work was to investigate the potential of high frequency ultrasound for the cleaning of a Polysulfone (PSU) ultrafiltration membrane used in hemodialysis. The blood substitute solution flowing through the hollow fiber membrane used in the High Flux F60 dialyzers has been sonicated by ultrasonic (US) waves with 1 MHz frequency and 2 W/cm2 in situ intensity. The solution was comprised of toxic compounds such as Urea, Creatinine, Vitamin B12 and Inulin. The effect of US was represented by comparison of the clearance in both OFF and ON ultrasound conditions. The results of these studies have been demonstrated that US can enhance the permeability of the PSU dialyzer membrane. Results revealed that US had significant effect (p-value ˂ 0.05) on the clearance of Inulin as a large molecule (5200 D) and accelerated its filtration by 28%. The proposed dialysis method can be used alongside the existing dialysis machine.</p></abstract>

The aim of this work was to investigate the potential of high frequency ultrasound for the cleaning of a Polysulfone (PSU) ultrafiltration membrane used in hemodialysis. The blood substitute solution flowing through the hollow fiber membrane used in the High Flux F60 dialyzers has been sonicated by ultrasonic (US) waves with 1 MHz frequency and 2 W/cm2 in situ intensity. The solution was comprised of toxic compounds such as Urea, Creatinine, Vitamin B12 and Inulin. The effect of US was represented by comparison of the clearance in both OFF and ON ultrasound conditions. The results of these studies have been demonstrated that US can enhance the permeability of the PSU dialyzer membrane. Results revealed that US had significant effect (p-value ˂ 0.05) on the clearance of Inulin as a large molecule (5200 D) and accelerated its filtration by 28%. The proposed dialysis method can be used alongside the existing dialysis machine.

Influence of ultrasound on the clearance of toxic substances from Polysulfone hollow fiber membrane used in a dialyzer filter

Department of Radiology Technology, Behbahan Faculty of Medical Sciences

Department of Immunology, Faculty of Allied Medical Sciences

Department of Medical Physics, Faculty of Medicine

Polish Journal of Medical Physics and Engineering

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

The aim of this work was to investigate the potential of high frequency ultrasound for the cleaning of a Polysulfone (PSU) ultrafiltration membrane used in...

Influence of ultrasound on the clearance of toxic substances from Polysulfone hollow fiber membrane used in a dialyzer filter

Published Online: Oct 04, 2018

Page range: 91 - 97

Received: Feb 02, 2018

Accepted: Jun 28, 2018

DOI: https://doi.org/10.2478/pjmpe-2018-0012

Keywords
hemodialysis, chronic kidney disease, ultrasound, hollow fiber membrane, filtration

© 2018 Behrouz Rasuli et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Influence of ultrasound on the clearance of toxic substances from Polysulfone hollow fiber membrane used in a dialyzer filter

Published Online: Oct 04, 2018

Page range: 91 - 97

Received: Feb 02, 2018

Accepted: Jun 28, 2018

DOI: https://doi.org/10.2478/pjmpe-2018-0012

Keywordshemodialysis, chronic kidney disease, ultrasound, hollow fiber membrane, filtration

© 2018 Behrouz Rasuli et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
hemodialysis, chronic kidney disease, ultrasound, hollow fiber membrane, filtration