New Studies on Dexketoprofen

1. Dexketoprofen, Summary of Product Characteristics. https://indeks.mp.pl/leki/desc.php?id=1738 (cited on November 5 2021); Search in Google Scholar

2. Esparza-Villalpando V, Pozos-Guillén A, Masuoka-Ito D, Gaitán-Fonseca C, Chavarría-Bolaños D. Analgesic efficacy of preoperative dexketoprofen trometamol: A systematic review and meta-analysis. Drug Dev Res. 2018;79(2):47-57;10.1002/ddr.2141929243848 Search in Google Scholar

3. Gaskell, H., Derry, S., Wiffen, P., & Ra, M. (2017). Single dose oral ketoprofen and dexketoprofen for acute postoperative pain in adults. The Cochrane Database of Systematic Reviews, 5, CD007355. http://doi.org/10.1002/14651858.CD007355.pub2; Search in Google Scholar

4. Esparza-Villalpando V, Pozos-Guillén A, Masuoka-Ito D, Gaitán-Fonseca C, Chavarría-Bolaños D. Analgesic efficacy of preoperative dexketoprofen trometamol: A systematic review and meta-analysis. Drug Dev Res. 2018;79(2):47-57;10.1002/ddr.21419 Search in Google Scholar

5. Kuczyńska J, Nieradko-Iwanicka B. The effect of ketoprofen lysine salt on mucosa of rat stomach after ethyl alcohol intoxication. BiomedPharmacother. 202;141:111938;10.1016/j.biopha.2021.11193834328086 Search in Google Scholar

6. Olmez S, Donmez S, Aslan M, Karadas S, Yavuz A. Esophagitis due to dexketoprofen trometamol: a rare case report. Wien Klin Wochenschr. 2015;127(9-10):399-401;10.1007/s00508-014-0658-625412595 Search in Google Scholar

7. Kılıc M, Tuylu BA. An in vitro investigation of genotoxic effects of dexketoprofen trometamol on healthy human lymphocytes. Drug ChemToxicol. 2020;43(2):174-181;10.1080/01480545.2018.148569030052082 Search in Google Scholar

8. Kayipmaz AE, Giray TA, Tasci SS, Tasci SS, Kavalci C, Kocalar UG. Acute dystonic reaction due to dexketoprofen trometamol. J Pak Med Assoc. 2015; 65(11):1231-2; Search in Google Scholar

9. Piirainen A, Kokki H, Immonen S, Eskelinen M, Häkkinen MR, Hautajärvi H, Kokki M. A Dose-Finding Study of Dexketoprofen in Patients Undergoing Laparoscopic Cholecystectomy: A Randomized Clinical Trial on Effects on the Analgesic Concentration of Oxycodone. Drugs R D. 2015;15(4):319-28;10.1007/s40268-015-0107-7466294826364041 Search in Google Scholar

10. Sánchez-Pérez A, Muñoz-Peñalver J, Moya-Villaescusa MJ, Sánchez-Matás C. Effects of the Preoperative Administration of Dexketoprofen Trometamol on Pain and Swelling After Implant Surgery: A Randomized, Double-Blind Controlled Trial. J Oral Implantol. 2018; 44(2):122-129;10.1563/aaid-joi-D-17-0018529356603 Search in Google Scholar

11. Demir U, Ince I, Aksoy M, Dostbil A, Arı MA, Sulak MM, Kose M, Tanios M, Ozmen O. The Effect of Pre-emptive Dexketoprofen Administration on Postoperative Pain Management in Patients with Ultrasound Guided Interscalene Block in Arthroscopic Shoulder Surgery. J Invest Surg. 2021;34(1):82-88;10.1080/08941939.2019.157680930966835 Search in Google Scholar

12. Anıl A, Kaya FN, Yavaşcaoğlu B, MercanoğluEfe E, Türker G, Demirci A. Comparison of postoperative analgesic efficacy of intraoperative single-dose intravenous administration of dexketoprofen trometamol and diclofenac sodium in laparoscopic cholecystectomy. J ClinAnesth. 2016; 32:127-33;10.1016/j.jclinane.2016.02.02027290960 Search in Google Scholar

13. Al B, Sunar MM, Zengin S, Sabak M, Bogan M, Can B, Kul S, Murat Oktay M, Eren SH. Comparison of IV dexketoprofen trometamol, fentanyl, and paracetamol in the treatment of renal colic in the ED: A randomized controlled trial. Am J Emerg Med. 2018;36(4):571-576;10.1016/j.ajem.2017.09.01929029797 Search in Google Scholar

14. Serinken M, Eken C, Karcıoğlu Ö. Intravenous Dexketoprofen versus Intravenous Paracetamol for Dysmenorrhea: A Randomized Controlled Trial. Balkan Med J. 2018 24;35(4):301-305;10.4274/balkanmedj.2016.0536606097429526831 Search in Google Scholar

15. Yilmaz A, Sabirli R, Ozen M, Turkcuer I, Erdur B, Arikan C, Demirozogul E, Sarohan A, Seyit M, Ok N. Intravenous paracetamol versus dexketoprofen in acute musculoskeletal trauma in the emergency department: A randomised clinical trial. Am J Emerg Med. 2019;37(5):902-908.10.1016/j.ajem.2018.08.02330100336 Search in Google Scholar

16. Demirozogul E, Yilmaz A, Ozen M, Turkcuer I, Seyit M, Arikan C. Intravenous dexketoprofen versus paracetamol in non-traumatic musculoskeletal pain in the emergency department: A randomized clinical trial. Am J Emerg Med. 2019; 37(12):2136-2142;10.1016/j.ajem.2019.01.04030744914 Search in Google Scholar

17. Cimen U, Yilmaz A, Cimen YK, Seyit M, Ozen M, Erdur B, Turkcuer I, Oncel G. Comparative evaluation of intravenous dexketoprofen and paracetamol in the management of pain induced by sore throat. Int J Clin Pract. 2021; 75(10):e14511;10.1111/ijcp.1451134118123 Search in Google Scholar

18. Yavuz E, Gulacti U, Lok U, Turgut K. Intravenous metoclopramide versus dexketoprofen trometamol versus metoclopramide+ dexketoprofen trometamol in acute migraine attack in the emergency department: A randomized double-blind controlled trial. Am J Emerg Med. 2020 Nov;38(11):2254-2258. doi: 10.1016/j.ajem.2020.04.038. Epub 2020 15. PMID: 32359776;32359776 Open DOISearch in Google Scholar

19. Gur STA, Ahiskalioglu EO, Aydin ME, Kocak AO, Aydin P, Ahiskalioglu A. Intravenous lidocaine vs. NSAIDs for migraine attack in the ED: a prospective, randomized, double-blind study. Eur J Clin Pharmacol. 2021 16. doi: 10.1007/s00228-021-03219-5. Epub ahead of print. PMID: 34528122;34528122 Open DOISearch in Google Scholar

20. Akbas I, Kocak AO, Akgol Gur ST, Oral Ahiskalioglu E, Dogruyol S, Dolanbay T, Demir M, Cakir Z. Lidocaine versus dexketoprofen in treatment of tension-type headache: A double-blind randomized controlled trial. Am J Emerg Med. 2021 Mar;41:125-129. doi: 10.1016/j.ajem.2020.12.057. Epub 2021 Jan 7. PMID: 33423013;33423013 Open DOISearch in Google Scholar

21. Seyhan AU, Yılmaz E. Treatment of Renal Colic by Nerve Blockade with Lidocaine Versus Intravenous Dexketoprofen. J Coll Physicians Surg Pak. 2021;31(8):921-925;10.29271/jcpsp.2021.08.92134320708 Search in Google Scholar

22. Taylan SB, Bariskaner H. Effects of dexmedetomidine and dexketoprofen on the conduction block of rat sciatic nerve. Neural Regen Res. 2020;15(5):929-935;10.4103/1673-5374.268926699079031719259 Search in Google Scholar

23. Akbas I, Kocak MB, Kocak AO, Gur STA, Dogruyol S, Demir M, Cakir Z. Intradermal mesotherapy versus intravenous dexketoprofen for the treatment of migraine headache without aura: a randomized controlled trial. Ann Saudi Med. 2021;41(3):127-134;10.5144/0256-4947.2021.127817637934085549 Search in Google Scholar

24. Akbas I, Kocak AO, Kocak MB, Cakir Z. Comparison of intradermal mesotherapy with systemic therapy in the treatment of low back pain: A prospective randomized study. Am J Emerg Med. 2020;38(7):1431-1435;10.1016/j.ajem.2019.11.04431859197 Search in Google Scholar

25. Moore RA, Gay-Escoda C, Figueiredo R, Tóth-Bagi Z, Dietrich T, Milleri S, Torres-Lagares D, Hill CM, García-García A, Coulthard P, Wojtowicz A, Matenko D, Peñarrocha-Diago M, Cuadripani S, Pizà-Vallespir B, Guerrero-Bayón C, Bertolotti M, Contini MP, Scartoni S, Nizzardo A, Capriati A, Maggi CA. Dexketoprofen/tramadol: randomised double-blind trial and confirmation of empirical theory of combination analgesics in acute pain. J Headache Pain. 2015;16:541;10.1186/s10194-015-0541-5448565926123824 Search in Google Scholar

26. Moore RA, McQuay HJ, Tomaszewski J, Raba G, Tutunaru D, Lietuviete N, Galad J, Hagymasy L, Melka D, Kotarski J, Rechberger T, Fülesdi B, Nizzardo A, Guerrero-Bayón C, Cuadripani S, Pizà-Vallespir B, Bertolotti M. Dexketoprofen/tramadol 25 mg/75 mg: randomised double-blind trial in moderate-to-severe acute pain after abdominal hysterectomy. BMC Anesthesiol. 2016; 16:9. doi: 10.1186/s12871-016-0174-5. Erratum in: BMC Anesthesiol. 2017; 17 (1):159. PMID: 26801905; PMCID: PMC4724087;472408726801905 Open DOISearch in Google Scholar

27. Romero-Alejo E, Puig MM, Romero A. Antihyperalgesic effects of dexketoprofen and tramadol in a model of postoperative pain in mice - effects on glial cell activation. J Pharm Pharmacol. 2016;68(8):1041-50;10.1111/jphp.1258427291294 Search in Google Scholar

28. Gay-Escoda C, Hanna M, Montero A, Dietrich T, Milleri S, Giergiel E, Zoltán TB, Varrassi G. Tramadol/dexketoprofen (TRAM/DKP) compared with tramadol/paracetamol in moderate to severe acute pain: results of a randomised, double-blind, placebo and active-controlled, parallel group trial in the impacted third molar extraction pain model (DAVID study). BMJ Open. 2019; 9(2):e023715. doi: 10.1136/bmjopen-2018-023715. Erratum in: BMJ Open. 2019; 9(6):e023715corr1. PMID: 30782886; PMCID: PMC6377526;637752630782886 Open DOISearch in Google Scholar

29. Hanna M, Montero A, Perrot S, Varrassi G. Tramadol/Dexketoprofen Analgesic Efficacy Compared with Tramadol/Paracetamol in Moderate to Severe Postoperative Acute Pain: Subgroup Analysis of a Randomized, Double-Blind, Parallel Group Trial-DAVID Study. Pain Ther. 2021; 10(1):485-503;10.1007/s40122-020-00228-7811957533575951 Search in Google Scholar

30. Meloncelli S, Divizia M, Germani G. Efficacy and tolerability of orally administered tramadol/dexketoprofen fixed-dose combination compared to diclofenac/thiocolchicoside in acute low back pain: experience from an Italian, single-centre, observational study. Curr Med Res Opin. 2020; 36(10):1687-169310.1080/03007995.2020.181422832838578 Search in Google Scholar

31. Cigerim L, Kaplan V. Evaluation of the analgesic efficacies of Dexketoprofen Trometamol and Dexketoprofen Trometamol + Thiocolchicoside combinations in the impacted third molar surgery: Randomised clinical trial. Med Oral Patol Oral Cir Bucal. 2019; 24(1):e114-e122. doi: 10.4317/medoral.22590. PMID: 30573719; PMCID: PMC6344008.634400830573719 Open DOISearch in Google Scholar

32. Sweed NM, Basalious EB, Nour SA. Combined site-specific release retardant mini-matrix tablets (C-SSRRMT) for extended oral delivery of dexketoprofen trometamol: in vitro evaluation and single versus multiple doses pharmacokinetic study in human volunteers. Drug Dev Ind Pharm. 2019;45(11):1777-1787;10.1080/03639045.2019.165673731418598 Search in Google Scholar

33. Öztürk AA, Kıyan HT. Treatment of oxidative stress-induced pain and inflammation with dexketoprofen trometamol loaded different molecular weight chitosan nanoparticles: Formulation, characterization and anti-inflammatory activity by using in vivo HET-CAM assay. Microvasc Res. 2020;128:103961. doi: 10.1016/j.mvr.2019.103961. Epub 2019 Nov 20. PMID: 31758946;31758946 Open DOISearch in Google Scholar

34. Erbaş O, Solmaz V, Aksoy D. Inhibitor effect of dexketoprofen in rat model of pentylenetetrazol- induced seizures. Neurol Res. 2015;37(12):1096-101;10.1179/1743132814Y.000000039124861495 Search in Google Scholar

35. Erdil A, Demirsoy MS, Çolak S, Duman E, Sümbül O, Aygun H. The effect of dexketoprofen trometamol on WAG/Rij rats with absence epilepsy (dexketoprofen in absence epilepsy). Neurol Res. 2021; 43(12):1116-1125;10.1080/01616412.2021.195251034278977 Search in Google Scholar

36. Ravera M, Zanellato I, Gabano E, Perin E, Rangone B, Coppola M, et al. Antiproliferative Activity of Pt(IV) Conjugates Containingthe Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Ketoprofen and Naproxen^†. Int J Mol Sci. 2019;20(12):3074;10.3390/ijms20123074662734131238499 Search in Google Scholar

37. Yu T, Lao X, Zheng H. Influencing COX-2 Activity by COX Related Pathways in Inflammation and Cancer. Mini Rev Med Chem. 2016;16(15):1230-1243;10.2174/138955751666616050511574327145850 Search in Google Scholar

38. Çoban Ö, Değim Z, Yılmaz Ş, Altıntaş L, Arsoy T, Sözmen M. Efficacy of targeted liposomes and nanocochleates containing imatinib plus dexketoprofen against fibrosarcoma. Drug Dev Res. 2019;80(5):556-565.10.1002/ddr.2153030901500 Search in Google Scholar