<abstract xmlns="http://www.w3.org/1999/xhtml">

The aim of our research was to prepare polymer-free hydroxypropyl-β-cyclodextrin-(HPβCD) and sulfobutylether-β-cyclodextrin (SBEβCD) based nanofibers. For this purpose, four-four viscous, aqueous solutions were prepared with different concentrations from each cyclodextrin derivative, with the following concentrations: 170, 180, 190 and 200% (v/w) from HPβCD and: 210, 220, 230 and 240% (v/w) from SBEβCD.
The parameters for the electrospinning process were: 1.5 ml/h flowrate, 22-24 G sized needle, and an applied voltage of 25 kV. The distance between the needle and the collector was 13-15 cm in the case of HPβCD, and 9-11 cm in the case of SBEβCD.
The obtained nanofibers were morphologically characterized and their dis-integration process was also tracked. Then, the results obtained were compared within each cyclodextrin group, in order to identify optimal spinning parameters and they were also discussed, based on previous reports.
From our results, we concluded that the 200% HPβCD solution is the most effective for nanofiber formation, producing smooth, homogenous fibers with small diameters, which present ideal disintegration properties. At the tested voltages, it was not possible to form ideal nanofibers from SBEβCD, however, we managed to form some nanofibers with acceptable quality, and the ones made out from the 240% solution of the SBEβCD were the most suitable.
</abstract>

The aim of our research was to prepare polymer-free hydroxypropyl-β-cyclodextrin-(HPβCD) and sulfobutylether-β-cyclodextrin (SBEβCD) based nanofibers. For this purpose, four-four viscous, aqueous solutions were prepared with different concentrations from each cyclodextrin derivative, with the following concentrations: 170, 180, 190 and 200% (v/w) from HPβCD and: 210, 220, 230 and 240% (v/w) from SBEβCD.
The parameters for the electrospinning process were: 1.5 ml/h flowrate, 22-24 G sized needle, and an applied voltage of 25 kV. The distance between the needle and the collector was 13-15 cm in the case of HPβCD, and 9-11 cm in the case of SBEβCD.
The obtained nanofibers were morphologically characterized and their dis-integration process was also tracked. Then, the results obtained were compared within each cyclodextrin group, in order to identify optimal spinning parameters and they were also discussed, based on previous reports.
From our results, we concluded that the 200% HPβCD solution is the most effective for nanofiber formation, producing smooth, homogenous fibers with small diameters, which present ideal disintegration properties. At the tested voltages, it was not possible to form ideal nanofibers from SBEβCD, however, we managed to form some nanofibers with acceptable quality, and the ones made out from the 240% solution of the SBEβCD were the most suitable.

Cyclodextrin-based nanofibers obtained by electrospinning

Department of Pharmaceutical industry and Management

George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Târgu Mureș

Bulletin of Medical Sciences

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"Cyclodextrin-based nanofibers obtained by electrospinning"}

The aim of our research was to prepare polymer-free hydroxypropyl-β-cyclodextrin-(HPβCD) and sulfobutylether-β-cyclodextrin (SBEβCD) based nanofibers. For this...

Cyclodextrin-based nanofibers obtained by electrospinning

Published Online: Oct 31, 2022

Page range: 118 - 129

DOI: https://doi.org/10.2478/orvtudert-2021-0017

Keywords
cyclodextrin, nanofiber, electrospinning, hydroxy-propyl-β-cyclodextrin, sulfobutylether-β-cyclodextrin

© 2021 Bucur Pálma et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Cyclodextrin-based nanofibers obtained by electrospinning

Published Online: Oct 31, 2022

Page range: 118 - 129

DOI: https://doi.org/10.2478/orvtudert-2021-0017

Keywordscyclodextrin, nanofiber, electrospinning, hydroxy-propyl-β-cyclodextrin, sulfobutylether-β-cyclodextrin

© 2021 Bucur Pálma et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
cyclodextrin, nanofiber, electrospinning, hydroxy-propyl-β-cyclodextrin, sulfobutylether-β-cyclodextrin