<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec>
<h3>Introduction</h3>
<p>The productivity of domestic animals and the safety of food products derived from them are jeopardised by mycotoxins in animal feed. To control them, feed additives are used, which limit the absorption of mycotoxins in the gastrointestinal tract of animals by binding to them. The study aimed to evaluate the effectiveness of a new <italic>in vitro</italic> model in experiments on the binding of mycotoxins from buffers and contaminated feed and to confirm the effect of a single sorbent or mixture in binding them.</p>
</sec>
<sec>
<h3>Material and Methods</h3>
<p>Nine mineral sorbents were tested for their efficiency binding eight mycotoxins. Two <italic>in vitro</italic> experiments were conducted to indicate the mycotoxin-binding capacity of sorbents, each specifying a buffer with one of two different pH levels reflecting gastrointestinal conditions (pH 3.5 and 7.0). The first investigated the sorbent with only the buffer and mycotoxin standards, while the second did so with the sorbent, buffer and feed naturally contaminated with mycotoxins (deoxynivalenol, zearalenone, and ochratoxin A).</p>
</sec>
<sec>
<h3>Results</h3>
<p>The sorption was significantly lower in the trial with feed. In the first experiment at gastric pH (pH 3.5), activated charcoal bound deoxynivalenol and sepiolite bound zearalenone at 70% and 96%, respectively, whereas in the second experiment with feed, the binding was only 3% and 6%.</p>
</sec>
<sec>
<h3>Conclusion</h3>
<p>The study underlines the challenge of finding a feed additive that would work comprehensively, binding all mycotoxins regulated by law.</p>
</sec>
</abstract>

Introduction
The productivity of domestic animals and the safety of food products derived from them are jeopardised by mycotoxins in animal feed. To control them, feed additives are used, which limit the absorption of mycotoxins in the gastrointestinal tract of animals by binding to them. The study aimed to evaluate the effectiveness of a new in vitro model in experiments on the binding of mycotoxins from buffers and contaminated feed and to confirm the effect of a single sorbent or mixture in binding them.


Material and Methods
Nine mineral sorbents were tested for their efficiency binding eight mycotoxins. Two in vitro experiments were conducted to indicate the mycotoxin-binding capacity of sorbents, each specifying a buffer with one of two different pH levels reflecting gastrointestinal conditions (pH 3.5 and 7.0). The first investigated the sorbent with only the buffer and mycotoxin standards, while the second did so with the sorbent, buffer and feed naturally contaminated with mycotoxins (deoxynivalenol, zearalenone, and ochratoxin A).


Results
The sorption was significantly lower in the trial with feed. In the first experiment at gastric pH (pH 3.5), activated charcoal bound deoxynivalenol and sepiolite bound zearalenone at 70% and 96%, respectively, whereas in the second experiment with feed, the binding was only 3% and 6%.


Conclusion
The study underlines the challenge of finding a feed additive that would work comprehensively, binding all mycotoxins regulated by law.

The efficiency of mycotoxin binding by sorbents in the <italic>in vitro</italic> model using a naturally contaminated animal feed

Journal of Veterinary Research

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The efficiency of mycotoxin binding by sorbents in the  model using a naturally contaminated animal feed

Introduction
The productivity of domestic animals and the safety of food products derived from them are jeopardised by mycotoxins in animal feed. To control...

The efficiency of mycotoxin binding by sorbents in the in vitro model using a naturally contaminated animal feed

Published Online: May 22, 2024

Page range: -

Received: Sep 19, 2023

Accepted: Apr 22, 2024

DOI: https://doi.org/10.2478/jvetres-2024-0023

Keywords
mycotoxin, mineral sorbents, mycotoxin binders, feed additives

© 2024 Adrianna Żybura et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The efficiency of mycotoxin binding by sorbents in the in vitro model using a naturally contaminated animal feed

Published Online: May 22, 2024

Page range: -

Received: Sep 19, 2023

Accepted: Apr 22, 2024

DOI: https://doi.org/10.2478/jvetres-2024-0023

Keywordsmycotoxin, mineral sorbents, mycotoxin binders, feed additives

© 2024 Adrianna Żybura et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
mycotoxin, mineral sorbents, mycotoxin binders, feed additives