Drug | Larval development test | ||
---|---|---|---|
LD50 | MIC | L3 larvae (%) ± SD at MIC | |
Thiabendazole | 0.37 | n.a. | 56.31 ± 5.19 |
Ivermectin | 28.87 | 173.6 | 45.73 ± 6.32 |
Levamisole | 0.10 | 1.0 | 0 ± 0 |
Species | Before treatment (%) | After treatment (%) | ||
---|---|---|---|---|
ALB | IVM | LEV | ||
77 | 100 | 100 | — | |
13 | — | — | — | |
7 | — | — | — | |
3 | — | — | — |
TBZ concentration (μg/mL) | Mean hatching (%) | ±SD |
---|---|---|
Control | 96.25 | 0.43 |
0.05 | 96.00 | 1.22 |
0.1 | 91.25 | 4.22 |
0.3 | 84.00 | 1.73 |
0.5 | 71.50 | 4.55 |
1 | 54.50 | 3.22 |
Mean ED50 ± SD | 1.22 | 0.08 |
Group (n = 10)/Treatment | Mean EPG ± SD | FECR(%) | ||
---|---|---|---|---|
Cabaret and Berrag formula (2004) (5) | Kochapakdee formula (1995)(16) | |||
Phase 1 | G1 Albendazole single dose | |||
D0 | 370 ± 205 | 0 | 0 | |
D10 | 1,465 ± 1,482 | |||
G2 Albendazole fasting dose | ||||
D0 | 1,525 ± 1,212 | 16.90 | 13.70 | |
D10 | 1,317 ± 986 | |||
G3 Albendazole divided dose | ||||
D0 | 710 ± 326 | 0 | 0 | |
D10 | 1,400 ± 794 | |||
G4 Albendazole double dose | ||||
D0 | 605 ± 321 | 0 | 0 | |
D10 | 1,680 ± 1,803 | |||
G5 Ivermectin | ||||
D0 | 350 ± 345 | 39.97 | 31.50 | |
D10 | 240 ± 232 | |||
Phase 2 | Levasmisole | |||
D0 | 2,233 ± 2,045 | 100 | 100 | |
D10 | 0 | |||
Control | ||||
D0 | 2,436 ± 1,239 | |||
D10 | 2,297 ± 968 |