<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec id="j_jvetres-2022-0003_s_005">
<h3>Introduction</h3>
<p>Bovine respiratory disease (BRD) is one of the primary causes of death in young calves. Vaccination against infection by the common bacteria causing BRD is possible; however, the physical condition of the young calves that enables antibody production when stimulated by early immunisation remains to be elucidated.</p>
</sec>
<sec id="j_jvetres-2022-0003_s_006">
<h3>Material and Methods</h3>
<p>Healthy young female Holstein calves on a commercial dairy farm were fed a colostrum replacer and administered primary and booster immunisations with an inactivated vaccine against the bacterial pneumonia agents <italic>Histophilus somni</italic>, <italic>Pasteurella multocida</italic> and <italic>Mannheimia haemolytica</italic>. At each immunisation, the body weight and height at the withers were measured and the body mass index (BMI) was calculated. Blood was sampled immediately before immunisation and 3 weeks following the booster. The calves were divided into positive and negative groups based on the antibody titre at the final blood sampling. Maternal antibody titres at the primary immunisation and BMI, nutritional status and oxidative stress at both immunisations were compared between the two groups.</p></sec>
<sec id="j_jvetres-2022-0003_s_007">
<h3>Results</h3>
<p>Antibody titre at the primary and BMI at both immunisations were significantly higher in the positive than in the negative group (P &lt; 0.05). Additionally, serum gamma globulin was significantly higher in the positive group (P &lt; 0.05), indicating a strong correlation between maternal antibody and serum gamma globulin levels.</p></sec>
<sec id="j_jvetres-2022-0003_s_008">
<h3>Conclusion</h3>
<p>Elevated maternal antibody titre and higher BMI are positive factors for successful early immunisation, for which suitable colostrum may also be fundamental in young calves administered inactivated vaccines.</p>
</sec>
</abstract>

Introduction
Bovine respiratory disease (BRD) is one of the primary causes of death in young calves. Vaccination against infection by the common bacteria causing BRD is possible; however, the physical condition of the young calves that enables antibody production when stimulated by early immunisation remains to be elucidated.


Material and Methods
Healthy young female Holstein calves on a commercial dairy farm were fed a colostrum replacer and administered primary and booster immunisations with an inactivated vaccine against the bacterial pneumonia agents Histophilus somni, Pasteurella multocida and Mannheimia haemolytica. At each immunisation, the body weight and height at the withers were measured and the body mass index (BMI) was calculated. Blood was sampled immediately before immunisation and 3 weeks following the booster. The calves were divided into positive and negative groups based on the antibody titre at the final blood sampling. Maternal antibody titres at the primary immunisation and BMI, nutritional status and oxidative stress at both immunisations were compared between the two groups.

Results
Antibody titre at the primary and BMI at both immunisations were significantly higher in the positive than in the negative group (P < 0.05). Additionally, serum gamma globulin was significantly higher in the positive group (P < 0.05), indicating a strong correlation between maternal antibody and serum gamma globulin levels.

Conclusion
Elevated maternal antibody titre and higher BMI are positive factors for successful early immunisation, for which suitable colostrum may also be fundamental in young calves administered inactivated vaccines.

Field trial of antibody response to inactivated bacterial vaccine in young Holstein calves: influence of animal health status

Journal of Veterinary Research

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Introduction
Bovine respiratory disease (BRD) is one of the primary causes of death in young calves. Vaccination against infection by the common bacteria...

Field trial of antibody response to inactivated bacterial vaccine in young Holstein calves: influence of animal health status

Published Online: Mar 25, 2022

Page range: 109 - 116

Received: Jul 04, 2021

Accepted: Jan 11, 2022

DOI: https://doi.org/10.2478/jvetres-2022-0003

Keywords
early vaccination, bovine respiratory disease, maternal antibody, nutritional status, oxidative stress

© 2022 K. Mori et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Field trial of antibody response to inactivated bacterial vaccine in young Holstein calves: influence of animal health status

Published Online: Mar 25, 2022

Page range: 109 - 116

Received: Jul 04, 2021

Accepted: Jan 11, 2022

DOI: https://doi.org/10.2478/jvetres-2022-0003

Keywordsearly vaccination, bovine respiratory disease, maternal antibody, nutritional status, oxidative stress

© 2022 K. Mori et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
early vaccination, bovine respiratory disease, maternal antibody, nutritional status, oxidative stress