E-test determination of antifungal susceptibility of Candida species isolated from turkeys
, , and | Nov 10, 2020
About this article
Published Online: Nov 10, 2020
Page range: 517 - 521
Received: May 14, 2020
Accepted: Oct 26, 2020
DOI: https://doi.org/10.2478/jvetres-2020-0072
Keywords
© 2020 I. Sokół et al. published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
Susceptibility patterns of Candida species isolated from turkeys’ intestinal tracts based on MIC values
| Antifungal agent | Susceptible | Dose-dependently susceptible | Resistant | |
|---|---|---|---|---|
| Amphotericin B | 10 (100%) | - | - | |
| Fluconazole | 10 (100%) | - | - | |
| Itraconazole | 1 (10%) | 7 (70%) | 2 (20%) | |
| Voriconazole | 10 (100%) | - | - | |
| Amphotericin B | 10 (100%) | - | - | |
| Fluconazole | 10 (100%) | - | - | |
| Itraconazole | 1 (10%) | 7 (70%) | 2 (20%) | |
| Voriconazole | 10 (100%) | - | - | |
| Amphotericin B | 10 (100%) | - | - | |
| Fluconazole | 10 (100%) | - | - | |
| Itraconazole | 5 (50%) | 5 (50%) | - | |
| Voriconazole | 10 (100%) | - | - | |
| Amphotericin B | 10 (100%) | - | - | |
| Fluconazole | 10 (100%) | - | - | |
| Itraconazole | 2 (20%) | 4 (40%) | 4 (40%) | |
| Voriconazole | 10 (100%) | - | - | |
| Amphotericin B | 10 (100%) | - | - | |
| Fluconazole | 10 (100%) | - | - | |
| Itraconazole | 2 (20%) | 5 (50%) | 3 (30%) | |
| Voriconazole | 10 (100%) | - | - | |
| Amphotericin B | - | 1 (100%) | - | |
| Fluconazole | 1 (100%) | - | - | |
| Itraconazole | - | 1 (100%) | - | |
| Voriconazole | 1 (100%) | - | - | |
| Amphotericin B | - | - | 1 (100%) | |
| Fluconazole | - | 1 (100%) | - | |
| Itraconazole | - | - | 1 (100%) | |
| Voriconazole | 1 (100%) | - | - | |
MICs (μg/mL) of antifungal agents for Candida isolates determined by E-test
| Antifungal agent | MICs μg/mL determined by E-test | MIC50 | MIC90 | Susceptibility breakpoints | Resistance breakpoints | |
|---|---|---|---|---|---|---|
| Amphotericin B | 0.125–1 | 0.38 | 1 | ≤1 | >1 | |
| Fluconazole | 0.125–0.75 | 0.19 | 0.75 | ≤2 | ≥8 | |
| Itraconazole | 0.125–1 | 0.38 | 1 | ≤0.125 | ≥1 | |
| Voriconazole | 0.002–0.094 | 0.012 | 0.094 | ≤0.12 | ≥1 | |
| Amphotericin B | 0.094–1 | 0.5 | 1 | ≤1 | >1 | |
| Fluconazole | 0.064–16 | 0.5 | 16 | ≤8 | ≥64 | |
| Itraconazole | 0.032–3 | 0.075 | 3 | ≤0.125 | ≥1 | |
| Voriconazole | 0.004–0.19 | 0.094 | 0,19 | ≤1 | ≥4 | |
| Amphotericin B | 0.125–1 | 0.19 | 1 | ≤1 | >1 | |
| Fluconazole | 0.75–4 | 2 | 4 | ≤8 | ≥64 | |
| Itraconazole | 0.125–0.38 | 0.125 | 0.38 | ≤0.125 | ≥1 | |
| Voriconazole | 0.012–0.38 | 0.064 | 0.38 | ≤1 | ≥4 | |
| Amphotericin B | 0.125–0.75 | 0.19 | 0.75 | ≤1 | >1 | |
| Fluconazole | 0.5–2 | 1 | 2 | ≤8 | ≥64 | |
| Itraconazole | 0.125–8 | 0.5 | 8 | ≤0.125 | ≥1 | |
| Voriconazole | 0.023–0.125 | 0.064 | 0,125 | ≤1 | ≥4 | |
| Amphotericin B | 0.19–0.5 | 0.25 | 0,5 | ≤1 | >1 | |
| Fluconazole | 0.25–1 | 0.75 | 1 | ≤8 | ≥64 | |
| Itraconazole | 0.125–1 | 0.38 | 1 | ≤0.125 | ≥1 | |
| Voriconazole | 0.006–0.047 | 0.012 | 0.047 | ≤1 | ≥4 | |
| Amphotericin B | 1.5 | - | - | ≤1 | >1 | |
| Fluconazole | 24 | - | - | ≤8 | ≥64 | |
| Itraconazole | 1 | - | - | ≤0.125 | ≥1 | |
| Voriconazole | 0.38 | - | - | ≤0.5 | ≥ 2 | |
| Amphotericin B | 0.5 | - | - | ≤1 | >1 | |
| Fluconazole | 0.25 | - | - | ≤8 | ≥64 | |
| Itraconazole | 0.19 | - | - | ≤0.125 | ≥1 | |
| Voriconazole | 0.02 | - | - | ≤1 | ≥4 | |