<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec id="j_jvetres-2020-0047_s_005">
<h3>Introduction</h3>
<p>Atrial fibrillation may potentially contribute to oxidative stress to a greater extent than chronic heart failure. The aim of the study was to compare the serum total antioxidant capacity and enzymatic antioxidant defence of dogs with chronic heart failure and atrial fibrillation with those of subjects with chronic heart failure and sinus rhythm and healthy controls.</p>
</sec>
<sec id="j_jvetres-2020-0047_s_006">
<h3>Material and Methods</h3>
<p>A total of 33 dogs were divided into three groups: dogs with chronic heart failure and atrial fibrillation (CHF + AF; n = 12), chronic heart failure and sinus rhythm (CHF + SR; n = 9), and healthy controls (n = 12). Serum total antioxidant capacity (TAC), serum CuZn-superoxide dismutase (SOD) and catalase, and plasma glutathione peroxidase (GPx) activity were determined.</p>
</sec>
<sec id="j_jvetres-2020-0047_s_007">
<h3>Results</h3>
<p>SOD activity and serum TAC were significantly lower in the study groups than in control animals. Catalase activity was significantly higher and plasma GPx activity significantly lower in dogs with CHF + AF compared with the CHF + SR and control dogs.</p>
</sec>
<sec id="j_jvetres-2020-0047_s_008">
<h3>Conclusion</h3>
<p>The results suggest that chronic heart failure in dogs significantly impacts the serum TAC and the antioxidant enzymatic defence, while plasma GPx activity is markedly lower in dogs with chronic heart failure and atrial fibrillation. The role of that imbalance needs further investigation.</p>
</sec></abstract>

Introduction
Atrial fibrillation may potentially contribute to oxidative stress to a greater extent than chronic heart failure. The aim of the study was to compare the serum total antioxidant capacity and enzymatic antioxidant defence of dogs with chronic heart failure and atrial fibrillation with those of subjects with chronic heart failure and sinus rhythm and healthy controls.


Material and Methods
A total of 33 dogs were divided into three groups: dogs with chronic heart failure and atrial fibrillation (CHF + AF; n = 12), chronic heart failure and sinus rhythm (CHF + SR; n = 9), and healthy controls (n = 12). Serum total antioxidant capacity (TAC), serum CuZn-superoxide dismutase (SOD) and catalase, and plasma glutathione peroxidase (GPx) activity were determined.


Results
SOD activity and serum TAC were significantly lower in the study groups than in control animals. Catalase activity was significantly higher and plasma GPx activity significantly lower in dogs with CHF + AF compared with the CHF + SR and control dogs.


Conclusion
The results suggest that chronic heart failure in dogs significantly impacts the serum TAC and the antioxidant enzymatic defence, while plasma GPx activity is markedly lower in dogs with chronic heart failure and atrial fibrillation. The role of that imbalance needs further investigation.

Serum total antioxidant capacity and enzymatic defence of dogs with chronic heart failure and atrial fibrillation: a preliminary study

Journal of Veterinary Research

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Introduction
Atrial fibrillation may potentially contribute to oxidative stress to a greater extent than chronic heart failure. The aim of the study was to...

Serum total antioxidant capacity and enzymatic defence of dogs with chronic heart failure and atrial fibrillation: a preliminary study

Published Online: Jul 28, 2020

Page range: 439 - 444

Received: Nov 07, 2019

Accepted: Jun 26, 2020

DOI: https://doi.org/10.2478/jvetres-2020-0047

Keywords
dogs, cardiology, atrial fibrillation, chronic heart failure, oxidative stress

© 2020 M. Michałek et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Serum total antioxidant capacity and enzymatic defence of dogs with chronic heart failure and atrial fibrillation: a preliminary study

Published Online: Jul 28, 2020

Page range: 439 - 444

Received: Nov 07, 2019

Accepted: Jun 26, 2020

DOI: https://doi.org/10.2478/jvetres-2020-0047

Keywordsdogs, cardiology, atrial fibrillation, chronic heart failure, oxidative stress

© 2020 M. Michałek et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
dogs, cardiology, atrial fibrillation, chronic heart failure, oxidative stress