<abstract xmlns="http://www.w3.org/1999/xhtml">



<p>Based on analysis of available genome sequences, five gene lineages of MHC class I molecules (MHC I-U, -Z, -S, -L and -P) and one gene lineage of MHC class II molecules (MHC II-D) have been identified in Osteichthyes. In the latter lineage, three MHC II molecule sublineages have been identified (MHC II-A, -B and -E). As regards MHC class I molecules in Osteichthyes, it is important to take note of the fact that the lineages U and Z in MHC I genes have been identified in almost all fish species examined so far. Phylogenetic studies into MHC II molecule genes of sublineages A and B suggest that they may be descended from the genes of the sublineage named A/B that have been identified in spotted gar (<italic>Lepisosteus oculatus</italic>). The sublineage E genes of MHC II molecules, which represent the group of non-polymorphic genes with poor expression in the tissues connected with the immune system, are present in primitive fish, <italic>i.e</italic>. in paddlefish, sturgeons and spotted gar (<italic>Lepisosteus oculatus</italic>), as well as in cyprinids (<italic>Cyprinidae</italic>), Atlantic salmon (<italic>Salmo salar</italic>), and rainbow trout (<italic>Oncorhynchus mykiss</italic>). Full elucidation of the details relating to the organisation and functioning of the particular components of the major histocompatibility complex in Osteichthyes can advance the understanding of the evolution of the MHC molecule genes and the immune mechanism.</p>

</abstract>

Based on analysis of available genome sequences, five gene lineages of MHC class I molecules (MHC I-U, -Z, -S, -L and -P) and one gene lineage of MHC class II molecules (MHC II-D) have been identified in Osteichthyes. In the latter lineage, three MHC II molecule sublineages have been identified (MHC II-A, -B and -E). As regards MHC class I molecules in Osteichthyes, it is important to take note of the fact that the lineages U and Z in MHC I genes have been identified in almost all fish species examined so far. Phylogenetic studies into MHC II molecule genes of sublineages A and B suggest that they may be descended from the genes of the sublineage named A/B that have been identified in spotted gar (Lepisosteus oculatus). The sublineage E genes of MHC II molecules, which represent the group of non-polymorphic genes with poor expression in the tissues connected with the immune system, are present in primitive fish, i.e. in paddlefish, sturgeons and spotted gar (Lepisosteus oculatus), as well as in cyprinids (Cyprinidae), Atlantic salmon (Salmo salar), and rainbow trout (Oncorhynchus mykiss). Full elucidation of the details relating to the organisation and functioning of the particular components of the major histocompatibility complex in Osteichthyes can advance the understanding of the evolution of the MHC molecule genes and the immune mechanism.

Major histocompatibility complex in Osteichthyes

Journal of Veterinary Research

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Major histocompatibility complex in Osteichthyes"}

Based on analysis of available genome sequences, five gene lineages of MHC class I molecules (MHC I-U, -Z, -S, -L and -P) and one gene lineage of MHC class II...

Major histocompatibility complex in Osteichthyes

Article Category: Review Article

Published Online: Mar 24, 2020

Page range: 127 - 136

Received: Aug 16, 2019

Accepted: Mar 06, 2020

DOI: https://doi.org/10.2478/jvetres-2020-0025

Keywords
Osteichthyes, major histocompatibility complex

© 2020 M. Stosik et al. published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Major histocompatibility complex in Osteichthyes

Article Category: Review Article

Published Online: Mar 24, 2020

Page range: 127 - 136

Received: Aug 16, 2019

Accepted: Mar 06, 2020

DOI: https://doi.org/10.2478/jvetres-2020-0025

KeywordsOsteichthyes, major histocompatibility complex

© 2020 M. Stosik et al. published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
Osteichthyes, major histocompatibility complex