<abstract xmlns="http://www.w3.org/1999/xhtml"><p><bold>Introduction:</bold> The clinical symptoms of portosystemic shunts (PSSs) and hepatic microvascular dysplasia (HMD) – portal vein hypoplasia (PVH) in dogs are similar. PSSs are abnormal vascular connections between the portal vein system and systemic veins. HMD is a very rare developmental vascular anomaly, recognisable during histopathological examination. The study aim was to assess the prevalence of HMD–PVH and hepatocellular and vascular pathologies in the liver. <bold>Material and Methods:</bold> Liver biopsies from 140 dogs (of different breeds and both sexes) arousing clinical suspicion of PSS were examined histopathologically. <bold>Results:</bold> An initial PSS diagnosis was confirmed in 125 dogs (89.29%). HMD–PVH was found in 12.32% of dogs, as an isolated disease in 9.29%, especially in Yorkshire terriers, and with extrahepatic PSS in 6.67%. Histopathological analysis of muscles around sublobular veins showed that HMD cases presented hypertrophy or hypertrophy with fibrosis. In 2.17% of all dogs with liver vascular developmental disorders calcification was visible around vessels (without correlation by degenerative changes in those vessels), suggesting prior onset of deep metabolic disorders. Clinical suspicion of PSS was also formed upon quite different pathological processes in young dogs. <bold>Conclusion:</bold> Histopathological findings diagnosed the type of vascular anomalies (PSS or HMD–PVH) or other pathological changes conclusively, therefore detailed hepatic histopathology is an indispensable component of the clinical diagnostic process.</p></abstract>

Introduction: The clinical symptoms of portosystemic shunts (PSSs) and hepatic microvascular dysplasia (HMD) – portal vein hypoplasia (PVH) in dogs are similar. PSSs are abnormal vascular connections between the portal vein system and systemic veins. HMD is a very rare developmental vascular anomaly, recognisable during histopathological examination. The study aim was to assess the prevalence of HMD–PVH and hepatocellular and vascular pathologies in the liver. Material and Methods: Liver biopsies from 140 dogs (of different breeds and both sexes) arousing clinical suspicion of PSS were examined histopathologically. Results: An initial PSS diagnosis was confirmed in 125 dogs (89.29%). HMD–PVH was found in 12.32% of dogs, as an isolated disease in 9.29%, especially in Yorkshire terriers, and with extrahepatic PSS in 6.67%. Histopathological analysis of muscles around sublobular veins showed that HMD cases presented hypertrophy or hypertrophy with fibrosis. In 2.17% of all dogs with liver vascular developmental disorders calcification was visible around vessels (without correlation by degenerative changes in those vessels), suggesting prior onset of deep metabolic disorders. Clinical suspicion of PSS was also formed upon quite different pathological processes in young dogs. Conclusion: Histopathological findings diagnosed the type of vascular anomalies (PSS or HMD–PVH) or other pathological changes conclusively, therefore detailed hepatic histopathology is an indispensable component of the clinical diagnostic process.

Retrospective liver histomorphological analysis in dogs in instances of clinical suspicion of congenital portosystemic shunt

Department of Pathology and Veterinary Diagnostics, Faculty of Veterinary Medicine

Department of Pathophysiology, Forensic Veterinary Medicine and Administration

University of Warmia and Mazury in Olsztyn

Scientific Circle of Veterinary Students, Department of Pathology and Veterinary Diagnostics, Faculty of Veterinary Medicine

Division of Small Animal Surgery and Anaesthesiology, Department of Small Animal Diseases with Clinic, Faculty of Veterinary Medicine

Journal of Veterinary Research

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Introduction: The clinical symptoms of portosystemic shunts (PSSs) and hepatic microvascular dysplasia (HMD) – portal vein hypoplasia (PVH) in dogs are...

Retrospective liver histomorphological analysis in dogs in instances of clinical suspicion of congenital portosystemic shunt

Published Online: Jun 20, 2019

Page range: 243 - 249

Received: Jan 02, 2019

Accepted: May 20, 2019

DOI: https://doi.org/10.2478/jvetres-2019-0026

Keywords
dog, hepatic microvascular dysplasia, congenital portosystemic shunt, histopathology, liver

© 2019 Małgorzata Sobczak-Filipiak et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Retrospective liver histomorphological analysis in dogs in instances of clinical suspicion of congenital portosystemic shunt

Published Online: Jun 20, 2019

Page range: 243 - 249

Received: Jan 02, 2019

Accepted: May 20, 2019

DOI: https://doi.org/10.2478/jvetres-2019-0026

Keywordsdog, hepatic microvascular dysplasia, congenital portosystemic shunt, histopathology, liver

© 2019 Małgorzata Sobczak-Filipiak et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
dog, hepatic microvascular dysplasia, congenital portosystemic shunt, histopathology, liver