<abstract xmlns="http://www.w3.org/1999/xhtml"><p>For many years, scientists have been pursuing research on skeletal muscle ageing both in humans and animals. Studies on animal models have extended our knowledge of this mechanism in humans. Most researchers agree that the major processes of muscle ageing occur in the mitochondria as the major energy production centres in muscle cells. It is believed that decisive changes occur at the enzymatic activity level as well as in protein synthesis and turnover ability. Deregulation of ion channels and oxidative stress also play significant roles. In particular, in recent years the free radical theory of ageing has undergone considerable modification; researchers are increasingly highlighting the partly positive effects of free radicals on processes occurring in cells. In addition, the influence of diet and physical activity on the rate of muscle cell ageing is widely debated as well as the possibility of delaying it through appropriate physical exercise and diet programmes. Numerous studies, especially those related to genetic processes, are still being conducted, and in the near future the findings could provide valuable information on muscle ageing. The results of ongoing research could answer the perennial question of whether and how we can influence the rate of ageing both in animals and humans.</p></abstract>

For many years, scientists have been pursuing research on skeletal muscle ageing both in humans and animals. Studies on animal models have extended our knowledge of this mechanism in humans. Most researchers agree that the major processes of muscle ageing occur in the mitochondria as the major energy production centres in muscle cells. It is believed that decisive changes occur at the enzymatic activity level as well as in protein synthesis and turnover ability. Deregulation of ion channels and oxidative stress also play significant roles. In particular, in recent years the free radical theory of ageing has undergone considerable modification; researchers are increasingly highlighting the partly positive effects of free radicals on processes occurring in cells. In addition, the influence of diet and physical activity on the rate of muscle cell ageing is widely debated as well as the possibility of delaying it through appropriate physical exercise and diet programmes. Numerous studies, especially those related to genetic processes, are still being conducted, and in the near future the findings could provide valuable information on muscle ageing. The results of ongoing research could answer the perennial question of whether and how we can influence the rate of ageing both in animals and humans.

Mitochondrial theory of skeletal muscle ageing –new facts, new doubts

Department of Animal Physiology, Physiotherapy and Nutrition, Faculty of Animal Breeding and Biology

Journal of Veterinary Research

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Mitochondrial theory of skeletal muscle ageing \u2013new facts, new doubts"}

For many years, scientists have been pursuing research on skeletal muscle ageing both in humans and animals. Studies on animal models have extended our...

Mitochondrial theory of skeletal muscle ageing –new facts, new doubts

Published Online: Mar 28, 2019

Page range: 149 - 160

Received: Jul 16, 2018

Accepted: Feb 27, 2019

DOI: https://doi.org/10.2478/jvetres-2019-0015

Keywords
muscle, ageing, mitochondria, enzymatic activity, ROS

© 2019 Sebastian Słodki et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Mitochondrial theory of skeletal muscle ageing –new facts, new doubts

Published Online: Mar 28, 2019

Page range: 149 - 160

Received: Jul 16, 2018

Accepted: Feb 27, 2019

DOI: https://doi.org/10.2478/jvetres-2019-0015

Keywordsmuscle, ageing, mitochondria, enzymatic activity, ROS

© 2019 Sebastian Słodki et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
muscle, ageing, mitochondria, enzymatic activity, ROS