<abstract xmlns="http://www.w3.org/1999/xhtml"><bold>Introduction:</bold> In the European Union, the use of thyreostatic drugs for fattening slaughter animals has been banned since 1981 under Council Directive 81/602/EEC. For protection of consumer health against unwanted residues and in compliance with Directive 96/23, each EU country must monitor thyreostats in samples of animal origin. This paper presents the results of research on thyreostatic residues carried out in Poland in 2011–2017.<bold>Material and Methods:</bold> The material for testing was urine (n = 3,491), drinking water (n = 127), and muscle samples (n = 349) officially collected by Veterinary Sanitary Inspectors in slaughterhouses and farms throughout the country in accordance with the national residue control plan. The samples were examined for the presence of tapazole, thiouracil, methylthiouracil, propylthiouracil, and phenylthiouracil using liquid chromatography tandem mass spectrometry through an accredited method.<bold>Results:</bold> In four bovine and three porcine urine samples, the permissible thiouracil concentration was exceeded. In one sample of porcine urine, methyl- and propylthiouracil were found. The presence of thiouracil and its derivatives in urine samples is most likely due to feeding animals diet containing cruciferous plants.<bold>Conclusions</bold>: The results of research indicate that thyreostats are not used for anabolic purposes in slaughter animals in Poland.</abstract>

Introduction: In the European Union, the use of thyreostatic drugs for fattening slaughter animals has been banned since 1981 under Council Directive 81/602/EEC. For protection of consumer health against unwanted residues and in compliance with Directive 96/23, each EU country must monitor thyreostats in samples of animal origin. This paper presents the results of research on thyreostatic residues carried out in Poland in 2011–2017.Material and Methods: The material for testing was urine (n = 3,491), drinking water (n = 127), and muscle samples (n = 349) officially collected by Veterinary Sanitary Inspectors in slaughterhouses and farms throughout the country in accordance with the national residue control plan. The samples were examined for the presence of tapazole, thiouracil, methylthiouracil, propylthiouracil, and phenylthiouracil using liquid chromatography tandem mass spectrometry through an accredited method.Results: In four bovine and three porcine urine samples, the permissible thiouracil concentration was exceeded. In one sample of porcine urine, methyl- and propylthiouracil were found. The presence of thiouracil and its derivatives in urine samples is most likely due to feeding animals diet containing cruciferous plants.Conclusions: The results of research indicate that thyreostats are not used for anabolic purposes in slaughter animals in Poland.

Control of residues of thyreostats in slaughter animals in Poland in 2011–2017

Department of Pharmacology and Toxicology, National Veterinary Research Institute

Journal of Veterinary Research

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Introduction: In the European Union, the use of thyreostatic drugs for fattening slaughter animals has been banned since 1981 under Council Directive...

Control of residues of thyreostats in slaughter animals in Poland in 2011–2017

Published Online: Dec 31, 2018

Page range: 511 - 517

Received: Jul 13, 2018

Accepted: Dec 12, 2018

DOI: https://doi.org/10.2478/jvetres-2018-0077

Keywords
thyreostats, thiouracil, urine, monitoring

© 2018 Barbara Woźniak et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Control of residues of thyreostats in slaughter animals in Poland in 2011–2017

Published Online: Dec 31, 2018

Page range: 511 - 517

Received: Jul 13, 2018

Accepted: Dec 12, 2018

DOI: https://doi.org/10.2478/jvetres-2018-0077

Keywordsthyreostats, thiouracil, urine, monitoring

© 2018 Barbara Woźniak et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
thyreostats, thiouracil, urine, monitoring