<abstract xmlns="http://www.w3.org/1999/xhtml"><sec id="j_jvetres-2018-0053_s_005_w2aab3b7c20b1b6b1aab1c16b1Aa"><h3>Introduction</h3><p>The study evaluated the ameliorative effects of <italic>Helianthus annuus</italic> leaf extract on nephrotoxicity, cardiac, and haematologic disorders in alloxan-induced hyperglycaemic rats.</p></sec><sec id="j_jvetres-2018-0053_s_006_w2aab3b7c20b1b6b1aab1c16b2Aa"><h3>Material and Methods</h3><p>The cold maceration method with 80% methanol was used in the preparation of <italic>H</italic>. <italic>annuus</italic> extract. Thirty alloxan-induced hyperglycaemic rats were randomly assigned to five equal groups (A–E). Groups A and B received 5% tween-20 solution in water (5 mL/kg) and glibenclamide (2 mg/kg), respectively; while groups C, D, and E received 150, 300, and 600 mg/kg of the extract, respectively, <italic>per os</italic> once daily for 21 consecutive days. The levels of serum urea, creatinine, haematological indices, and histopathological changes in the kidneys and heart were evaluated 24 h after the last treatment on day 21.</p></sec><sec id="j_jvetres-2018-0053_s_007_w2aab3b7c20b1b6b1aab1c16b3Aa"><h3>Results</h3><p>The extract and glibenclamide significantly (P &lt; 0.05) reduced the levels of serum urea and urea : creatinine ratio in diabetic rats when compared with the vehicle treated group. The extract and glibenclamide also ameliorated haematological disorders and kidney and cardiac damage induced by alloxan.</p></sec><sec id="j_jvetres-2018-0053_s_008_w2aab3b7c20b1b6b1aab1c16b4Aa"><h3>Conclusion</h3><p><italic>H. annuus</italic> extract produced nephroprotective, cardioprotective, and haematoprotective effects and might prevent the advancement of diabetic complications such as diabetic nephropathy and cardiovascular diseases in diabetic patients.</p></sec></abstract>

IntroductionThe study evaluated the ameliorative effects of Helianthus annuus leaf extract on nephrotoxicity, cardiac, and haematologic disorders in alloxan-induced hyperglycaemic rats.Material and MethodsThe cold maceration method with 80% methanol was used in the preparation of H. annuus extract. Thirty alloxan-induced hyperglycaemic rats were randomly assigned to five equal groups (A–E). Groups A and B received 5% tween-20 solution in water (5 mL/kg) and glibenclamide (2 mg/kg), respectively; while groups C, D, and E received 150, 300, and 600 mg/kg of the extract, respectively, per os once daily for 21 consecutive days. The levels of serum urea, creatinine, haematological indices, and histopathological changes in the kidneys and heart were evaluated 24 h after the last treatment on day 21.ResultsThe extract and glibenclamide significantly (P < 0.05) reduced the levels of serum urea and urea : creatinine ratio in diabetic rats when compared with the vehicle treated group. The extract and glibenclamide also ameliorated haematological disorders and kidney and cardiac damage induced by alloxan.ConclusionH. annuus extract produced nephroprotective, cardioprotective, and haematoprotective effects and might prevent the advancement of diabetic complications such as diabetic nephropathy and cardiovascular diseases in diabetic patients.

Ameliorative effects of Helianthus annuus against nephrotoxic, cardiac, and haematological disorders in alloxan-induced hyperglycaemia in albino rats

Department of Veterinary Physiology and Pharmacology

Michael Okpara University of Agriculture Umudike

Journal of Veterinary Research

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

IntroductionThe study evaluated the ameliorative effects of Helianthus annuus leaf extract on nephrotoxicity, cardiac, and haematologic disorders in...

Ameliorative effects of Helianthus annuus against nephrotoxic, cardiac, and haematological disorders in alloxan-induced hyperglycaemia in albino rats

Published Online: Oct 23, 2018

Page range: 371 - 377

Received: Apr 27, 2018

Accepted: Sep 17, 2018

DOI: https://doi.org/10.2478/jvetres-2018-0053

Keywords
rats, diabetes mellitus, nephro-, cardio-, haematoprotective properties

© 2018 S.O. Onoja et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Ameliorative effects of Helianthus annuus against nephrotoxic, cardiac, and haematological disorders in alloxan-induced hyperglycaemia in albino rats

Published Online: Oct 23, 2018

Page range: 371 - 377

Received: Apr 27, 2018

Accepted: Sep 17, 2018

DOI: https://doi.org/10.2478/jvetres-2018-0053

Keywordsrats, diabetes mellitus, nephro-, cardio-, haematoprotective properties

© 2018 S.O. Onoja et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
rats, diabetes mellitus, nephro-, cardio-, haematoprotective properties