<abstract xmlns="http://www.w3.org/1999/xhtml"><sec id="j_jvetres-2018-0029_s_005_w2aab3b7c12b1b6b1aab1c16b1Aa"><h3>Introduction</h3><p>Lameness is a painful and debilitating condition that affects dairy cows worldwide. The aim of this study was to determine the plasma concentration of norepinephrine, β-endorphin, and substance P in dairy cows with lameness and different mobility scores (MS).</p></sec><sec id="j_jvetres-2018-0029_s_006_w2aab3b7c12b1b6b1aab1c16b2Aa"><h3>Material and Methods</h3><p>A total of 100 Friesian and Jersey cows with lameness (parity range: 1–6; weight: 400–500 kg; milk yield: 22–28 L a day, and lactation stage less than 230 days) were selected. Animals were selected and grouped according to MS (MS 0–3; n = 25), and plasma concentration of norepinephrine, substance P, and β-endorphin was measured using ELISA.</p></sec><sec id="j_jvetres-2018-0029_s_007_w2aab3b7c12b1b6b1aab1c16b3Aa"><h3>Results</h3><p>Cows with MS 3 had higher plasma concentrations of norepinephrine and substance P and lower plasma concentrations of β-endorphins when compared to MS 0 cows.</p></sec><sec id="j_jvetres-2018-0029_s_008_w2aab3b7c12b1b6b1aab1c16b4Aa"><h3>Conclusion</h3><p>Variations in plasma concentration of norepinephrine, substance P, and β-endorphin could be associated with intense pain states in dairy cows with lameness, but are insufficient to differentiate these states from the mildest pain states. Further studies are necessary in order to evaluate the potential use of these biomarkers in the detection of chronic bovine painful conditions.</p></sec></abstract>

IntroductionLameness is a painful and debilitating condition that affects dairy cows worldwide. The aim of this study was to determine the plasma concentration of norepinephrine, β-endorphin, and substance P in dairy cows with lameness and different mobility scores (MS).Material and MethodsA total of 100 Friesian and Jersey cows with lameness (parity range: 1–6; weight: 400–500 kg; milk yield: 22–28 L a day, and lactation stage less than 230 days) were selected. Animals were selected and grouped according to MS (MS 0–3; n = 25), and plasma concentration of norepinephrine, substance P, and β-endorphin was measured using ELISA.ResultsCows with MS 3 had higher plasma concentrations of norepinephrine and substance P and lower plasma concentrations of β-endorphins when compared to MS 0 cows.ConclusionVariations in plasma concentration of norepinephrine, substance P, and β-endorphin could be associated with intense pain states in dairy cows with lameness, but are insufficient to differentiate these states from the mildest pain states. Further studies are necessary in order to evaluate the potential use of these biomarkers in the detection of chronic bovine painful conditions.

Plasma concentration of norepinephrine, β-endorphin, and substance P in lame dairy cows

Journal of Veterinary Research

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

IntroductionLameness is a painful and debilitating condition that affects dairy cows worldwide. The aim of this study was to determine the plasma concentration...

Plasma concentration of norepinephrine, β-endorphin, and substance P in lame dairy cows

Published Online: Jul 07, 2018

Page range: 193 - 197

Received: Feb 21, 2018

Accepted: Jun 13, 2018

DOI: https://doi.org/10.2478/jvetres-2018-0029

Keywords
dairy cows, norepinephrine, β-endorphin, substance P, lameness

© 2018 Alfredo Rosamel Rodriguez et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Plasma concentration of norepinephrine, β-endorphin, and substance P in lame dairy cows

Published Online: Jul 07, 2018

Page range: 193 - 197

Received: Feb 21, 2018

Accepted: Jun 13, 2018

DOI: https://doi.org/10.2478/jvetres-2018-0029

Keywordsdairy cows, norepinephrine, β-endorphin, substance P, lameness

© 2018 Alfredo Rosamel Rodriguez et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
dairy cows, norepinephrine, β-endorphin, substance P, lameness