<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Biopesticides are generally considered a safer and more environmentally friendly alternative to conventional pesticides. Plant metabolites display a range of pest specific activity ranging from antimicrobial to larvicidal and nematocidal. We herein describe the evaluation of a Guyanese collection of <italic>Vismia guianensis</italic> (Clusiaceae) for anthelmintic activity. The bioassay-guided evaluation of the hexane extract yielded the new prenylated benzophenone 8,9-epoxyvismiaphenone F (<bold>1</bold>). The final structures were elucidated based on spectral analysis and comparison to the known metabolite. To evaluate the anthelmintic efficacy of these compounds, <italic>Caenorhabditis elegans</italic> were exposed to the compounds via a ring assay model. Post-exposure, the numbers of live <italic>C. elegans</italic> in the compound (middle), bacteria ring were recorded for 3 d, as well as the total number of live worms for each plate. Compound <bold>1</bold> reduced <italic>C. elegans</italic>’ overall growth and reproduction, suggesting that these prenylated benzophenones may hold some promise as natural pesticides.</p></abstract>

Biopesticides are generally considered a safer and more environmentally friendly alternative to conventional pesticides. Plant metabolites display a range of pest specific activity ranging from antimicrobial to larvicidal and nematocidal. We herein describe the evaluation of a Guyanese collection of Vismia guianensis (Clusiaceae) for anthelmintic activity. The bioassay-guided evaluation of the hexane extract yielded the new prenylated benzophenone 8,9-epoxyvismiaphenone F (1). The final structures were elucidated based on spectral analysis and comparison to the known metabolite. To evaluate the anthelmintic efficacy of these compounds, Caenorhabditis elegans were exposed to the compounds via a ring assay model. Post-exposure, the numbers of live C. elegans in the compound (middle), bacteria ring were recorded for 3 d, as well as the total number of live worms for each plate. Compound 1 reduced C. elegans’ overall growth and reproduction, suggesting that these prenylated benzophenones may hold some promise as natural pesticides.

Prenylated Benzophenones from <italic>Vismia guianensis</italic> Reduced Nematode Growth and Chemotaxis

Journal of Nematology

This work is licensed under the Creative Commons Attribution 4.0 International License.

Prenylated Benzophenones from  Reduced Nematode Growth and Chemotaxis

Biopesticides are generally considered a safer and more environmentally friendly alternative to conventional pesticides. Plant metabolites display a range of...

Prenylated Benzophenones from Vismia guianensis Reduced Nematode Growth and Chemotaxis

Article Category: Research Paper

Published Online: Jan 08, 2023

Page range: -

Received: Apr 06, 2022

DOI: https://doi.org/10.2478/jofnem-2022-0054

Keywords
anthelminthic, behavior, biopesticides, interaction, Vismia guianensis

© 2022 Walter de Gruyter GmbH, Berlin/Boston

This work is licensed under the Creative Commons Attribution 4.0 International License.

Prenylated Benzophenones from Vismia guianensis Reduced Nematode Growth and Chemotaxis

Article Category: Research Paper

Published Online: Jan 08, 2023

Page range: -

Received: Apr 06, 2022

DOI: https://doi.org/10.2478/jofnem-2022-0054

Keywordsanthelminthic, behavior, biopesticides, interaction, Vismia guianensis

© 2022 Walter de Gruyter GmbH, Berlin/Boston

This work is licensed under the Creative Commons Attribution 4.0 International License.

Keywords
anthelminthic, behavior, biopesticides, interaction, Vismia guianensis