<abstract xmlns="http://www.w3.org/1999/xhtml"><p>An approximate semi-analytical solution based on a Hankel transform of a mechanistic model for electrical impedance spectroscopy (EIS) is derived for a non-invasive axisymmetric concentric probe with <italic>m</italic> electrodes measuring the response of <italic>n</italic> layers of human skin. We validate the semi-analytical solution for the case when the skin is treated as a three-layer entity - (<italic>i</italic>) stratum corneum, (<italic>ii</italic>) viable skin comprising living epidermis and dermis and (<italic>iii</italic>) adipose tissue – on the volar forearm in the frequency range 1 kHz to 1 MHz with experimental EIS measurements of 120 young subjects. Overall, we find good agreement for both the mean magnitude and phase of the impedance as well as the natural variability between subjects. Finally, the semi-analytical solution is verified with the full set of equations solved numerically: Good agreement is found for the point-wise potential distribution in the three skin layers.</p></abstract>

An approximate semi-analytical solution based on a Hankel transform of a mechanistic model for electrical impedance spectroscopy (EIS) is derived for a non-invasive axisymmetric concentric probe with m electrodes measuring the response of n layers of human skin. We validate the semi-analytical solution for the case when the skin is treated as a three-layer entity - (i) stratum corneum, (ii) viable skin comprising living epidermis and dermis and (iii) adipose tissue – on the volar forearm in the frequency range 1 kHz to 1 MHz with experimental EIS measurements of 120 young subjects. Overall, we find good agreement for both the mean magnitude and phase of the impedance as well as the natural variability between subjects. Finally, the semi-analytical solution is verified with the full set of equations solved numerically: Good agreement is found for the point-wise potential distribution in the three skin layers.

Mechanistic multilayer model for non-invasive bioimpedance of intact skin

Department of Chemical and Biomolecular Engineering

Journal of Electrical Bioimpedance

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Mechanistic multilayer model for non-invasive bioimpedance of intact skin"}

An approximate semi-analytical solution based on a Hankel transform of a mechanistic model for electrical impedance spectroscopy (EIS) is derived for a...

Mechanistic multilayer model for non-invasive bioimpedance of intact skin

Article Category: Research articles

Published Online: Aug 18, 2018

Page range: 31 - 38

Received: Mar 19, 2018

DOI: https://doi.org/10.2478/joeb-2018-0006

Keywords
Mathematical model, electrical impedance, stratum corneum, viable skin, adipose tissue, analytical solution

© 2018 Tsai B, Birgersson E, Birgersson U, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Mechanistic multilayer model for non-invasive bioimpedance of intact skin

Article Category: Research articles

Published Online: Aug 18, 2018

Page range: 31 - 38

Received: Mar 19, 2018

DOI: https://doi.org/10.2478/joeb-2018-0006

KeywordsMathematical model, electrical impedance, stratum corneum, viable skin, adipose tissue, analytical solution

© 2018 Tsai B, Birgersson E, Birgersson U, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
Mathematical model, electrical impedance, stratum corneum, viable skin, adipose tissue, analytical solution