<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Systemic lupus erythematosus (SLE), the prototype autoimmune disease, is characterized by the production of a plethora of autoantibodies with various roles in the development of disease-related tissue damage. C-reactive protein (CRP) is an acute phase reactant with a pentameric structure. Under acidic or alkaline conditions, or when urea levels are high and/or calcium levels are low, the pentamer (pCRP) dissociates irreversibly into monomeric CRP (mCRP) and exposes new epitopes (neo-CRP). Importantly, anti-mCRP (but not anti-pCRP) antibodies have been described in patients with SLE, their prevalence varying from 4% to 78% in different cohorts. Numerous studies have investigated the relationship between autoantibodies directed against CRP (anti-CRP) and disease activity as well as their association with lupus nephritis (LN), frequently reporting discrepant findings. The main objective of the present review is to describe the role of anti-mCRP antibodies in SLE according to the currently available data.</p></abstract>

Systemic lupus erythematosus (SLE), the prototype autoimmune disease, is characterized by the production of a plethora of autoantibodies with various roles in the development of disease-related tissue damage. C-reactive protein (CRP) is an acute phase reactant with a pentameric structure. Under acidic or alkaline conditions, or when urea levels are high and/or calcium levels are low, the pentamer (pCRP) dissociates irreversibly into monomeric CRP (mCRP) and exposes new epitopes (neo-CRP). Importantly, anti-mCRP (but not anti-pCRP) antibodies have been described in patients with SLE, their prevalence varying from 4% to 78% in different cohorts. Numerous studies have investigated the relationship between autoantibodies directed against CRP (anti-CRP) and disease activity as well as their association with lupus nephritis (LN), frequently reporting discrepant findings. The main objective of the present review is to describe the role of anti-mCRP antibodies in SLE according to the currently available data.

A Review of Anti-C Reactive Protein Antibodies in Systemic Lupus Erythematosus

Department of Rheumatology and Physiotherapy

“Grigore T. Popa” University of Medicine and Pharmacy

Journal of Interdisciplinary Medicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"A Review of Anti-C Reactive Protein Antibodies in Systemic Lupus Erythematosus"}

Systemic lupus erythematosus (SLE), the prototype autoimmune disease, is characterized by the production of a plethora of autoantibodies with various roles in...

A Review of Anti-C Reactive Protein Antibodies in Systemic Lupus Erythematosus

Published Online: Jul 17, 2021

Page range: 60 - 66

Received: Apr 06, 2021

Accepted: Apr 28, 2021

DOI: https://doi.org/10.2478/jim-2021-0017

Keywords
systemic lupus erythematosus, lupus nephritis, anti-CRP antibodies, SLEDAI

© 2021 Patricia Richter et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

A Review of Anti-C Reactive Protein Antibodies in Systemic Lupus Erythematosus

Published Online: Jul 17, 2021

Page range: 60 - 66

Received: Apr 06, 2021

Accepted: Apr 28, 2021

DOI: https://doi.org/10.2478/jim-2021-0017

Keywordssystemic lupus erythematosus, lupus nephritis, anti-CRP antibodies, SLEDAI

© 2021 Patricia Richter et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
systemic lupus erythematosus, lupus nephritis, anti-CRP antibodies, SLEDAI