<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Acute fatty liver of pregnancy (AFLP) is a rare but life-threatening condition that develops in the third trimester of pregnancy. AFLP shares similar clinical features with other more common pregnancy-associated conditions. However, early correct diagnosis is important for maternal and fetal survival. Once the diagnosis has been established, immediate delivery and maternal intensive support should be undertaken. Both parents and the infant should be tested for deficiencies of the mitochondrial fatty acid oxidation, especially for long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD) deficiency, as many cases of AFLP are related to disruption of this physiological enzymatic pathway.</p></abstract>

Acute fatty liver of pregnancy (AFLP) is a rare but life-threatening condition that develops in the third trimester of pregnancy. AFLP shares similar clinical features with other more common pregnancy-associated conditions. However, early correct diagnosis is important for maternal and fetal survival. Once the diagnosis has been established, immediate delivery and maternal intensive support should be undertaken. Both parents and the infant should be tested for deficiencies of the mitochondrial fatty acid oxidation, especially for long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD) deficiency, as many cases of AFLP are related to disruption of this physiological enzymatic pathway.

Acute Fatty Liver of Pregnancy

“Carol Davila” University of Medicine and Pharmacy

Journal of Interdisciplinary Medicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Acute Fatty Liver of Pregnancy"}

Acute fatty liver of pregnancy (AFLP) is a rare but life-threatening condition that develops in the third trimester of pregnancy. AFLP shares similar clinical...

Acute Fatty Liver of Pregnancy

Published Online: Jun 29, 2020

Page range: 23 - 26

Received: Nov 11, 2019

Accepted: Feb 10, 2020

DOI: https://doi.org/10.2478/jim-2020-0001

Keywords
acute fatty liver of pregnancy, long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency, Swansea criteria, newborn metabolic screening

© 2020 Lucian Gheorghe Pop et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Acute Fatty Liver of Pregnancy

Published Online: Jun 29, 2020

Page range: 23 - 26

Received: Nov 11, 2019

Accepted: Feb 10, 2020

DOI: https://doi.org/10.2478/jim-2020-0001

Keywordsacute fatty liver of pregnancy, long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency, Swansea criteria, newborn metabolic screening

© 2020 Lucian Gheorghe Pop et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
acute fatty liver of pregnancy, long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency, Swansea criteria, newborn metabolic screening