<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Dilated cardiomyopathy (DCM) is the most common type of cardiomyopathy in children. Heart transplantation is considered standard therapy in dilated cardiomyopathy with end-stage heart failure. We present a case of a 15-year-old patient diagnosed with DCM in the neonatal period, who underwent heart transplantation for end-stage heart failure. Despite the use of induction therapy, the endomyocardial biopsy performed at two weeks post-transplant revealed mixed moderate cellular (2R) and humoral (pAMR2) allograft rejection. Aggressive rejection treatment was initiated with good outcome. Besides endomyocardial biopsy, advanced echocardiography can also be a valuable noninvasive tool for rejection assessment.</p></abstract>

Dilated cardiomyopathy (DCM) is the most common type of cardiomyopathy in children. Heart transplantation is considered standard therapy in dilated cardiomyopathy with end-stage heart failure. We present a case of a 15-year-old patient diagnosed with DCM in the neonatal period, who underwent heart transplantation for end-stage heart failure. Despite the use of induction therapy, the endomyocardial biopsy performed at two weeks post-transplant revealed mixed moderate cellular (2R) and humoral (pAMR2) allograft rejection. Aggressive rejection treatment was initiated with good outcome. Besides endomyocardial biopsy, advanced echocardiography can also be a valuable noninvasive tool for rejection assessment.

Early Acute Graft Rejection in a Heart Transplanted Child with Dilated Cardiomyopathy

“George Emil Palade” University of Medicine, Pharmacy, Science and Technology

Journal of Cardiovascular Emergencies

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Dilated cardiomyopathy (DCM) is the most common type of cardiomyopathy in children. Heart transplantation is considered standard therapy in dilated...

Early Acute Graft Rejection in a Heart Transplanted Child with Dilated Cardiomyopathy

Published Online: Jul 06, 2020

Page range: 43 - 47

Received: Apr 08, 2020

Accepted: May 04, 2020

DOI: https://doi.org/10.2478/jce-2020-0007

Keywords
heart transplantation, acute rejection, dilated cardiomyopathy, advanced echo-cardiography, children

© 2020 Iolanda Muntean et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Early Acute Graft Rejection in a Heart Transplanted Child with Dilated Cardiomyopathy

Published Online: Jul 06, 2020

Page range: 43 - 47

Received: Apr 08, 2020

Accepted: May 04, 2020

DOI: https://doi.org/10.2478/jce-2020-0007

Keywordsheart transplantation, acute rejection, dilated cardiomyopathy, advanced echo-cardiography, children

© 2020 Iolanda Muntean et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
heart transplantation, acute rejection, dilated cardiomyopathy, advanced echo-cardiography, children