<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>A patient diagnosed with late-presenting HIV infection [CD4 count 86 cells/mm<sup>3</sup>, viral load (VL) 95 000 copies RNA/mL], treated with DRV/c 800/150 mg (Rezolsta®) and TDF/FTC 200/245 mg, was hospitalized with ischemic brain stroke, confirmed by CT scan and MRI. Motor functions quickly recovered, but nausea, abdominal heaviness, ascites, and hepatosplenomegaly appeared. Laboratory investigations revealed anaemia, thrombocytopenia, normal transaminases, increased GGT and negative serological tests for HBV and HCV and she was diagnosed with Gastroenterologists diagnosed liver cirrhosis. After 20 days of hospital treatment, the patient recovered from the stroke and ascites but with persisting anaemia and thrombocytopenia. Liver cirrhosis had been confirmed, and relevant treatment had been administered. Six months later, an MRI of the brain revealed an improved image. Follow-up showed stabilized somatic and neurologic status, improved laboratory parameters, stable T-helper count and undetectable viral load (VL). ART regimen continued with Raltegravir 400 mg (Isentress®) 2×1 tablet/24 h, TDF/FTC 200/245 mg 1 tablet/24 h. Three months later, the patient continued her treatment continued abroad. The increased access to precise diagnosis and treatment with improved adherence has transformed the HIV-infection into a manageable chronic health condition, even in complicated cases.</p>
</abstract>

A patient diagnosed with late-presenting HIV infection [CD4 count 86 cells/mm3, viral load (VL) 95 000 copies RNA/mL], treated with DRV/c 800/150 mg (Rezolsta®) and TDF/FTC 200/245 mg, was hospitalized with ischemic brain stroke, confirmed by CT scan and MRI. Motor functions quickly recovered, but nausea, abdominal heaviness, ascites, and hepatosplenomegaly appeared. Laboratory investigations revealed anaemia, thrombocytopenia, normal transaminases, increased GGT and negative serological tests for HBV and HCV and she was diagnosed with Gastroenterologists diagnosed liver cirrhosis. After 20 days of hospital treatment, the patient recovered from the stroke and ascites but with persisting anaemia and thrombocytopenia. Liver cirrhosis had been confirmed, and relevant treatment had been administered. Six months later, an MRI of the brain revealed an improved image. Follow-up showed stabilized somatic and neurologic status, improved laboratory parameters, stable T-helper count and undetectable viral load (VL). ART regimen continued with Raltegravir 400 mg (Isentress®) 2×1 tablet/24 h, TDF/FTC 200/245 mg 1 tablet/24 h. Three months later, the patient continued her treatment continued abroad. The increased access to precise diagnosis and treatment with improved adherence has transformed the HIV-infection into a manageable chronic health condition, even in complicated cases.

Immune Reconstitution in Late-Presenting HIV-Positive a Case with Idiopathic Liver Cirrhosis and Ischemic Brain Stroke

Department of Infectious Diseases, Epidemiology, Parasitology and Tropical Medicine, Faculty of Public Health

Journal of Biomedical and Clinical Research

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

A patient diagnosed with late-presenting HIV infection [CD4 count 86 cells/mm3, viral load (VL) 95 000 copies RNA/mL], treated with DRV/c 800/150 mg...

Immune Reconstitution in Late-Presenting HIV-Positive a Case with Idiopathic Liver Cirrhosis and Ischemic Brain Stroke

Published Online: Aug 10, 2023

Page range: 66 - 73

Received: Jan 12, 2023

Accepted: Jun 15, 2023

DOI: https://doi.org/10.2478/jbcr-2023-0010

Keywords
HIV, ischemic brain stroke, liver cirrhosis, late-presenting, immune reconstitution

© 2023 Ivaylo N. Pakov, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Immune Reconstitution in Late-Presenting HIV-Positive a Case with Idiopathic Liver Cirrhosis and Ischemic Brain Stroke

Published Online: Aug 10, 2023

Page range: 66 - 73

Received: Jan 12, 2023

Accepted: Jun 15, 2023

DOI: https://doi.org/10.2478/jbcr-2023-0010

KeywordsHIV, ischemic brain stroke, liver cirrhosis, late-presenting, immune reconstitution

© 2023 Ivaylo N. Pakov, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
HIV, ischemic brain stroke, liver cirrhosis, late-presenting, immune reconstitution