<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>It was believed in the past that only the lower genital tract is inhabited by microorganisms, and the cervix was considered as a perfect barrier against the ascension of microbes. Nowadays, many studies using new sequencing technologies examining microbiomes with low biomass show that the microorganisms are gradually changing from the lower to the upper genital tract with decreasing bacterial abundance and increasing bacterial diversity. It is well documented that the endometrium is a non-sterile area, and in healthy women, the Lactobacillus spp. is the dominant flora. Lactobacillus - as a dominant endometrial microbiome, has a crucial role in implantation, early pregnancy development. It is also essential for a good pregnancy outcome. Non-Lactobacillus-dominant microbiome is associated with poor reproductive outcomes (recurrent implantation failure, recurrent miscarriages, outgoing pregnancy). This association is evidence of its significance for reproductive health.</p>
<p>We present a case of unsuccessful first pregnancy with concurrent bacterial endometrial infection. A definitive antibiotic treatment resulted in a successful full-term second pregnancy. We present the influence of pathogenic microorganisms on uterine function and pregnancy development, current possibilities for diagnosis and treatment.</p>
</abstract>

It was believed in the past that only the lower genital tract is inhabited by microorganisms, and the cervix was considered as a perfect barrier against the ascension of microbes. Nowadays, many studies using new sequencing technologies examining microbiomes with low biomass show that the microorganisms are gradually changing from the lower to the upper genital tract with decreasing bacterial abundance and increasing bacterial diversity. It is well documented that the endometrium is a non-sterile area, and in healthy women, the Lactobacillus spp. is the dominant flora. Lactobacillus - as a dominant endometrial microbiome, has a crucial role in implantation, early pregnancy development. It is also essential for a good pregnancy outcome. Non-Lactobacillus-dominant microbiome is associated with poor reproductive outcomes (recurrent implantation failure, recurrent miscarriages, outgoing pregnancy). This association is evidence of its significance for reproductive health.
We present a case of unsuccessful first pregnancy with concurrent bacterial endometrial infection. A definitive antibiotic treatment resulted in a successful full-term second pregnancy. We present the influence of pathogenic microorganisms on uterine function and pregnancy development, current possibilities for diagnosis and treatment.

The Role of Uterine Infection in Pregnancy Outcome: A Case Report

Center for reproductive health, Medical University

Journal of Biomedical and Clinical Research

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"The Role of Uterine Infection in Pregnancy Outcome: A Case Report"}

It was believed in the past that only the lower genital tract is inhabited by microorganisms, and the cervix was considered as a perfect barrier against the...

The Role of Uterine Infection in Pregnancy Outcome: A Case Report

Published Online: Jan 18, 2022

Page range: 178 - 181

Received: Jul 29, 2021

Accepted: Nov 25, 2021

DOI: https://doi.org/10.2478/jbcr-2021-0022

Keywords
endometrial microbiome, Lactobacillus, endometritis, plasmatic cells, antibiotics

© 2021 Tatyana T. Bodurska et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

The Role of Uterine Infection in Pregnancy Outcome: A Case Report

Published Online: Jan 18, 2022

Page range: 178 - 181

Received: Jul 29, 2021

Accepted: Nov 25, 2021

DOI: https://doi.org/10.2478/jbcr-2021-0022

Keywordsendometrial microbiome, Lactobacillus, endometritis, plasmatic cells, antibiotics

© 2021 Tatyana T. Bodurska et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
endometrial microbiome, Lactobacillus, endometritis, plasmatic cells, antibiotics