<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Chronic lymphocytic leukemia is one of the most common types of leukemia affecting adults over 65 years of age [1]. The disease is a part of the so-called indolent lymphomas and has a variable clinical course, defined by many factors. In recent years, knowing better the pathogenetic mechanisms of the disease, significant advances in the treatment have been made [2]. Monoclonal antibodies, immunomodulators, tyrosine kinase inhibitors, anti-apoptotic Bcl-2 protein inhibitors have been approved for clinical practice. Nevertheless, the development of tumor resistance and recurrence of the disease remains a challenge for hematologists, biologists, and pharmacists. We present two clinical cases of patients of both age groups (young adults and adults), in whom treatment was started with a Bruton’s tyrosine kinase (BTK) inhibitor, after inadequate response to immunochemotherapy (CIT).</p></abstract>

Chronic lymphocytic leukemia is one of the most common types of leukemia affecting adults over 65 years of age [1]. The disease is a part of the so-called indolent lymphomas and has a variable clinical course, defined by many factors. In recent years, knowing better the pathogenetic mechanisms of the disease, significant advances in the treatment have been made [2]. Monoclonal antibodies, immunomodulators, tyrosine kinase inhibitors, anti-apoptotic Bcl-2 protein inhibitors have been approved for clinical practice. Nevertheless, the development of tumor resistance and recurrence of the disease remains a challenge for hematologists, biologists, and pharmacists. We present two clinical cases of patients of both age groups (young adults and adults), in whom treatment was started with a Bruton’s tyrosine kinase (BTK) inhibitor, after inadequate response to immunochemotherapy (CIT).

The Different Faces of Chronic Lymphocytic Leukemia -Two Clinical Cases

Journal of Biomedical and Clinical Research

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"The Different Faces of Chronic Lymphocytic Leukemia -Two Clinical Cases"}

Chronic lymphocytic leukemia is one of the most common types of leukemia affecting adults over 65 years of age [1]. The disease is a part of the so-called...

The Different Faces of Chronic Lymphocytic Leukemia -Two Clinical Cases

Published Online: Jan 21, 2021

Page range: 63 - 66

Received: Jan 20, 2020

Accepted: Sep 08, 2020

DOI: https://doi.org/10.2478/jbcr-2020-0010

Keywords
low doses Ibrutinib, lymphocytic leukemia, secondary cancer

© 2020 Vanya S. Popova et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

The Different Faces of Chronic Lymphocytic Leukemia -Two Clinical Cases

Published Online: Jan 21, 2021

Page range: 63 - 66

Received: Jan 20, 2020

Accepted: Sep 08, 2020

DOI: https://doi.org/10.2478/jbcr-2020-0010

Keywordslow doses Ibrutinib, lymphocytic leukemia, secondary cancer

© 2020 Vanya S. Popova et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
low doses Ibrutinib, lymphocytic leukemia, secondary cancer