<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Emerging evidence indicates that inflammation in atopic dermatitis (AD) is associated with immune-mediated abnormalities in the skin. The history and severity of AD are risk factors for dust mite allergy. Bee venom (BV) is used in a complementary medicine to treat various diseases and skin disorders. Purified BV is obtained through electric stunning with a BV collector, without the harming of honeybees, followed by the removal of impurities from the collected BV and lyophilization of the final product. To evaluate the therapeutic potential of purified BV for AD, we investigated the anti-inflammatory effects of BV on house dust mite (<italic>Dermatophagoides farinae</italic>) antigen-stimulated HaCaT keratinocytes. The results showed that <italic>D. farinae</italic> induced significant increased levels of protease-activated receptor 2 (PAR2), intercellular adhesion molecule-1 (ICAM-1), and interleukin-6 (IL-6) compared to those in the normal control. However, purified BV inhibited the elevated expression of PAR2, ICAM-1 and IL-6 at the gene and protein levels. Thus, purified BV may have a therapeutic potential for the treatment and management of AD.</p></abstract>

Emerging evidence indicates that inflammation in atopic dermatitis (AD) is associated with immune-mediated abnormalities in the skin. The history and severity of AD are risk factors for dust mite allergy. Bee venom (BV) is used in a complementary medicine to treat various diseases and skin disorders. Purified BV is obtained through electric stunning with a BV collector, without the harming of honeybees, followed by the removal of impurities from the collected BV and lyophilization of the final product. To evaluate the therapeutic potential of purified BV for AD, we investigated the anti-inflammatory effects of BV on house dust mite (Dermatophagoides farinae) antigen-stimulated HaCaT keratinocytes. The results showed that D. farinae induced significant increased levels of protease-activated receptor 2 (PAR2), intercellular adhesion molecule-1 (ICAM-1), and interleukin-6 (IL-6) compared to those in the normal control. However, purified BV inhibited the elevated expression of PAR2, ICAM-1 and IL-6 at the gene and protein levels. Thus, purified BV may have a therapeutic potential for the treatment and management of AD.

Anti-Atopic Dermatitis of Purified Bee Venom on Keratinocytes Via Suppression of PAR2, ICAM-1, and IL-6 Expression

National Institute of Agricultural Science

Journal of Apicultural Science

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Emerging evidence indicates that inflammation in atopic dermatitis (AD) is associated with immune-mediated abnormalities in the skin. The history and severity...

Anti-Atopic Dermatitis of Purified Bee Venom on Keratinocytes Via Suppression of PAR2, ICAM-1, and IL-6 Expression

Published Online: Dec 24, 2018

Page range: 179 - 188

Received: Dec 10, 2017

Accepted: Jul 01, 2018

DOI: https://doi.org/10.2478/jas-2018-0016

Keywords
atopic dermatitis, bee venom,

© 2018 Sang Mi Han et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Anti-Atopic Dermatitis of Purified Bee Venom on Keratinocytes Via Suppression of PAR2, ICAM-1, and IL-6 Expression

Published Online: Dec 24, 2018

Page range: 179 - 188

Received: Dec 10, 2017

Accepted: Jul 01, 2018

DOI: https://doi.org/10.2478/jas-2018-0016

Keywordsatopic dermatitis, bee venom,

© 2018 Sang Mi Han et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
atopic dermatitis, bee venom,